HPLC of Formula: 1445-73-4In 2020 ,《Propargylated monocarbonyl curcumin analogues: synthesis, bioevaluation and molecular docking study》 appeared in Medicinal Chemistry Research. The author of the article were Nagargoje, Amol A.; Akolkar, Satish V.; Subhedar, Dnyaneshwar D.; Shaikh, Mubarak H.; Sangshetti, Jaiprakash N.; Khedkar, Vijay M.; Shingate, Bapurao B.. The article conveys some information:
Abstract: In the current exptl. study, we have synthesized new monocarbonyl curcumin analogs bearing propargyl ether moiety in their structure and evaluated for in vitro antifungal and radical scavenging activity. The antifungal activity was carried out against five human pathogenic fungal strains such as Candida albicans, Fusarium oxysporum, Aspergillus flavus, Aspergillus niger and Cryptococcus neoformans. Most of the curcumin analogs displayed excellent to moderate fungicidal activity when compared with standard drug Miconazole. Also, synthesized analogs exhibited potential radical scavenging activity as compared with standard antioxidant Butylated hydroxyl toluene (BHT). Based on biol. data, structure-activity relationship (SAR) were also discussed. Furthermore, in silico computational study was carried out to know binding interactions of synthesized analogs in the active sites of enzyme sterol 14α-demethylase (CYP51). [graphic not available: see fulltext] In addition to this study using 1-Methyl-4-piperidone, there are many other studies that have used 1-Methyl-4-piperidone(cas: 1445-73-4HPLC of Formula: 1445-73-4) was used in this study.
1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.HPLC of Formula: 1445-73-4
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem