《Diffusion of reduced arecoline and arecaidine through human vaginal and buccal mucosa》 was written by Van der Bijl, P.; Van Eyk, A. D.; Van Wyk, C. W.; Stander, I. A.. Category: piperidines And the article was included in Journal of Oral Pathology & Medicine on April 30 ,2001. The article conveys some information:
Because alkaloids from areca nut, arecoline and arecaidine, have been implicated in the development of oral submucous fibrosis, the authors determined their diffusion kinetics through human buccal and vaginal mucosa. Four clin. healthy vaginal mucosa specimens (mean patient age ± standard deviation: 47±15 yr; age range: 31-60 yr) and 4 buccal mucosa specimens from 2 male patients and 2 female patients (mean patient age ± standard deviation: 31±9 yr; age range: 17-53 yr) were obtained during surgery. In vitro flux rates of reduced arecoline and arecaidine (r-arecoline and r-arecaidine) were determined by use of a flow-through diffusion apparatus Anal. of variance, a Duncan multiple range test, and an unpaired t-test were used to determine steady state kinetics and flux differences over time intervals. Although statistically significant differences were observed between flux values for both alkaloids and tissues at certain time points, these were not considered to be of biol. (clin.) significance. However, the flux rates across both mucosa of r-arecoline were significantly higher statistically than those of r-arecaidine. The findings demonstrated the differences in the diffusion kinetics between r-arecoline and r-arecaidine across human buccal and vaginal mucosa, an observation that could be explained in terms of their ionization characteristics. Addnl., the results obtained further support the hypothesis that human vaginal mucosa can be used as a model for buccal mucosa in studies of permeability to various chem. compounds The results came from multiple reactions, including the reaction of Methyl 1-methylpiperidine-3-carboxylate(cas: 1690-72-8Category: piperidines)
Methyl 1-methylpiperidine-3-carboxylate(cas: 1690-72-8) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.Category: piperidines
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem