With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1892-22-4,3-Aminopiperidin-2-one,as a common compound, the synthetic route is as follows.
To a solution of 3-aminophthalic acid (0.100 g, 0.552 mmol) in DMF (1.1 mL) was added 3-aminopiperidine-2-one (0.063 g, 0.552 mmol) and the reaction was stirred at 90 C over 18 h. Volatiles were removed in vacuo and the dark-brown crude residue was purified by preparative reverse phase HPLC to give the desired product 28 (0.050 g, 35%) as an off-white powder. 1H NMR (400 MHz, DMSO) delta 7.83 (s, 1H), 7.43 (dd, J = 8.3, 7.1 Hz, 1H), 7.07 – 6.87 (m, 2H), 6.47 (br s, 2H), 4.49 (dd, J = 11.9, 6.3 Hz, 1H), 3.27 – 3.10 (m, 2H), 2.19 (dt, J = 12.0, 7.7 Hz, 1H), 2.05 – 1.72 (m, 3H). MS (ESI) m/z calcd for C13H14N3O3 [M+H]+ 260.3, found: 260.9.
The synthetic route of 1892-22-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Taiho Pharmaceutical Co., Ltd.; PARK, Eun, Sun; PELISH, Henry, E.; CLARKE, Astrid, S.; WILLIAMS, Grace, L.; CASTALDI, Maria, Paola; AREFOLOV, Alexander; RING, Jennifer, E.; SHAIR, Matthew, D.; KING, Randall, W.; (58 pag.)EP2582836; (2018); B1;,
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