With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.135634-18-3,(2,4-Difluorophenyl)(piperidin-4-yl)methanone oxime hydrochloride,as a common compound, the synthetic route is as follows.
Potassium hydroxide (27 g) was added to 600 mL of methanol and added(2,4-difluorophenyl) – (4-piperidinyl) methanone oxime hydrochloride (55 g)Heating reaction for about 2.5 hours. Cold to room temperature, add appropriate amount of anhydrous MgSO4, stirring about 1h. The filtrate was concentrated under reduced pressure. Join500 mL of acetone, stirred at room temperature for about 0.5 h, filtered, the filtrate stirred into the hydrochloric acid to pH = 2 ~ 3, filter, dry, white solidBody 35g. The methanol content is 0.4%.
135634-18-3, The synthetic route of 135634-18-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Beijing Pharmaceutical Group Co., Ltd.; Wang Qichang; Liu Moyi; Liu Qingliang; Zou Jiang; Yang Yan; (9 pag.)CN106831742; (2017); A;,
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