With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1022150-11-3,(R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.
Compound (IV) (Pgi = Pg2 = Boc) (2.93 g, 5 mmol) was dissolved in MeOH (15 ml), then 33% HC1 (3 ml) was added, and the reaction mass was heated at 50C for 4 st with intensive stirring (note: a foam is forming during the reaction due to isolation of gaseous by-products). After completion of the reaction the resulting solution was cooled to room temperature and evaporated to dryness (note: the vapor contains HC1). Saturated Na2CO3 solution (5 ml) was added to the dry residue and the mixture was extracted with EtOAc (3 x 10 ml). The extract was dried over Na2SO4 and evaporated in vacuum. Yield 1.89 g (98%), white amorphous mass., 1022150-11-3
As the paragraph descriping shows that 1022150-11-3 is playing an increasingly important role.
Reference£º
Patent; LATVIAN INSTITUTE OF ORGANIC SYNTHESIS; LEBEDEVS, Antons; PONOMARJOVS, Jurijs; VARACEVA, Larisa; CERNAKS, Dmitrijs; CERNOBROVIJS, Aleksandrs; LAVRINOVICS, Edvards; (15 pag.)WO2017/39425; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem