In 2015,Chakka, Sai Kumar; Kalamuddin, Mohammad; Sundararaman, Srividhya; Wei, Lianhu; Mundra, Sourabh; Mahesh, Radhakrishnan; Malhotra, Pawan; Mohmmed, Asif; Kotra, Lakshmi P. published 《Identification of novel class of falcipain-2 inhibitors as potential antimalarial agents》.Bioorganic & Medicinal Chemistry published the findings.Related Products of 622-26-4 The information in the text is summarized as follows:
Falcipain-2 is a papain family cysteine protease and an emerging antimalarial drug target. A pseudo-tripeptide scaffold I was designed using in silico screening tools and the three dimensional structures of falcipain-2, falcipain-3, and papain. This scaffold was investigated at four positions, T1, T2, T3, and T3′, with various targeted substitutions to understand the structure-activity relationships. Inhibitor synthesis was accomplished by first obtaining the appropriate dipeptide precursors with common structural components. The pyrrolidine moiety introduced interesting rotamers in a number of synthesized mols., which was confirmed using high-temperature 1H NMR spectroscopy. Among the synthesized compounds, three inhibited falcipain-2 activity with inhibition constants (Ki) of 1.8±1.1, 0.2±0.1 and 7.0±2.3 μM, resp. A group of mols. with a pyrrolidine moiety at the T2 position also potently inhibited falcipain-2 activity (Ki = 0.4±0.1, 2.5±0.5, 3.3±1.1, 7.5±1.9, and 4.6±0.7 μM, resp.). Overall, compound I exhibited potent antiparasitic activity (IC50 = 0.9±0.1 μM), corresponding with its inhibitory activity against falcipain-2, with a Ki of 1.1±0.1 μM. Two other compounds inhibited the growth of the drug resistant parasite Dd2 with better efficacy, and compound I exhibited a 7- to 12-fold higher potency against Dd2 and MCamp isolates, than the laboratory strain (3D7). These data suggest that this novel series of compounds should be further investigated as potential antimalarial agents. In the experimental materials used by the author, we found 2-(Piperidin-4-yl)ethanol(cas: 622-26-4Related Products of 622-26-4)
2-(Piperidin-4-yl)ethanol(cas: 622-26-4) can be used to synthese ursolic acid derivatives, spiroimidazolidinone NPC1L1 inhibitors, neurokinin-2 receptor antagonists, antagonists for inhibition of platelet aggregation.Related Products of 622-26-4
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem