Cui, Hao’s team published research in European Journal of Medicinal Chemistry in 2022 | CAS: 87120-72-7

tert-Butyl 4-aminopiperidine-1-carboxylate(cas: 87120-72-7) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.COA of Formula: C10H20N2O2

COA of Formula: C10H20N2O2In 2022 ,《Design and synthesis of dual inhibitors targeting snail and histone deacetylase for the treatment of solid tumor cancer》 appeared in European Journal of Medicinal Chemistry. The author of the article were Cui, Hao; Huang, Jingkun; Lei, Yan; Chen, Quanwei; Hu, Zan; Niu, Jiaqi; Wei, Ran; Yang, Kang; Li, Hongmei; Lu, Tao; Zhu, Yong; Huang, Yatian. The article conveys some information:

In this work, a series of Snail/HDAC dual inhibitors I (R = H, F; R1 = (1H-pyrazol-3-yl)aminyl, [1-[(tert-butoxy)carbonyl]piperidin-4-yl]aminyl, morpholin-4-yl, [(4-fluorophenyl)methyl]aminyl, etc.) were synthesized. Compound I (R = F; R1 = (5-methyl-1H-pyrazol-3-yl)aminyl) displayed the most potent inhibitory activity against HDAC1 with an IC50 of 0.405μM, potent inhibition against Snail with a Kd of 0.180μM, and antiproliferative activity in HCT-116 cell lines with an IC50 of 0.0751μM. Compound I (R = F; R1 = (5-methyl-1H-pyrazol-3-yl)aminyl) showed a good inhibitory effect on NCI-H522 (GI50 = 0.0488μM), MDA-MB-435 (GI50 = 0.0361μM), and MCF7 (GI50 = 0.0518μM). Docking studies showed that compound I (R = F; R1 = (5-methyl-1H-pyrazol-3-yl)aminyl) can be well docked into the active binding sites of Snail and HDAC. Further studies showed that compound I (R = F; R1 = (5-methyl-1H-pyrazol-3-yl)aminyl) increased histone H4 acetylation in HCT-116 cells and decreased the expression of Snail protein to induce cell apoptosis. These findings highlight the potential for the development of Snail/HDAC dual inhibitors as anti-solid tumor cancer drugs. In the experiment, the researchers used tert-Butyl 4-aminopiperidine-1-carboxylate(cas: 87120-72-7COA of Formula: C10H20N2O2)

tert-Butyl 4-aminopiperidine-1-carboxylate(cas: 87120-72-7) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.COA of Formula: C10H20N2O2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem