《A novel and simple strategy for the synthesis of γ-carboline》 was published in Eurasian Chemical Communications in 2020. These research results belong to Gaikwad, Sunil V.; Gaikwad, Milind V.; Lokhande, Pradeep D.. Reference of 1-Methyl-4-piperidone The article mentions the following:
This study introduces a novel and efficient approach for the oxidative aromatization of tetrahydro-γ-carbolines I (R = H, Me, Bn; R1 = H, Cl; R2 = H, Me, Cl, F) using CuCl2.2H2O and I2, H2O2 in DMSO. This method was applied for all kinds of C-3 substituted tetrahydro-γ-carbolines (THγC) I units to access the corresponding aromatic γ-carbolines II. With a 0.25 mol% CuCl2.2H2O as a catalyst, THγC I could be efficiently oxidized to γ-carbolines II at 100°C with excellent yield. This protocol was also generalized for the aromatization of tetrahydro-β-carboline-3-carboxylic acids III (Ar = 3-bromophenyl, 4-methylphenyl, 4-(propan-2-yl)phenyl, 3,4,5-trimethoxyphenyl) to corresponding β-carboline-3-carboxylic acids IV. The entire synthesized new compounds II and IV were characterized by using 1HNMR, 13CNMR and Mass spectroscopy technique. To the best of knowledge, this is the first synthesis of γ-carbolines II via an oxidative aromatization of THγC I. In the part of experimental materials, we found many familiar compounds, such as 1-Methyl-4-piperidone(cas: 1445-73-4Reference of 1-Methyl-4-piperidone)
1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.Reference of 1-Methyl-4-piperidone
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem