Safety of 2-(Piperidin-4-yl)ethanolIn 2012 ,《Investigations of primary and secondary amine carbamate stability by 1H NMR spectroscopy for post combustion capture of carbon dioxide》 appeared in Journal of Chemical Thermodynamics. The author of the article were Fernandes, Debra; Conway, William; Burns, Robert; Lawrance, Geoffrey; Maeder, Marcel; Puxty, Graeme. The article conveys some information:
Carbamate formation is one of the major chem. reactions that can occur in solution in the capture of CO2 by amine-based solvents, and carbamate formation makes a significant enthalpy contribution to the absorption-desorption of CO2 that occurs in the absorber/stripper columns of the PCC process. Consequently, the formation of carbamates of selected series of primary and secondary amines over the temperature range (288 to 318) K has been investigated by equilibrium 1H NMR studies, and the stability constants (K 9) for the equilibrium:RNH2+HCO3-⇄K9RNHCOO-+H2Oare reported. van’t Hoff analyses have resulted in standard molar enthalpies, ΔHmo, and entropies, ΔSmo, of carbamate formation. A ΔHmo-ΔSmo plot generates a linear correlation for carbamate formation (providing a mean standard molar free energy, ΔGmo, for carbamate formation of about -7 kJ · mol-1), and this relationship helps provide a guide to the selection of an amine(s) solvent for CO2 capture, in terms of enthalpy considerations. A linear ΔHmo-ΔSmo plot also occurs for carbamate protonation. The formation of the carbamates has been correlated with systematic changes in composition and structure, and steric effects have been identified by comparing mol. geometries obtained using d. functional B3LYP/6-311++G(d,p) calculations Trends in steric effects have been identified in the series of compounds monoethanolamine (MEA), 1-amino-2-propanol, 2-amino-1-propanol (AP) and 2-amino-2-methyl-1-propanol (AMP). In the case of 2-piperidinemethanol, 2-piperidineethanol and 3-piperidinemethanol, strong intramol. hydrogen bonding is shown to be the likely cause for lack of carbamate formation, and in the ring systems of pyrrolidine, morpholine, piperidine and thiomorpholine trends in carbamate formation (as given by K 9) have been correlated with the internal ring angle at the amine nitrogen, as well as the planarity of the environment around the nitrogen atom. In the part of experimental materials, we found many familiar compounds, such as 2-(Piperidin-4-yl)ethanol(cas: 622-26-4Safety of 2-(Piperidin-4-yl)ethanol)
2-(Piperidin-4-yl)ethanol(cas: 622-26-4) have been used as an intermediate in the synthetic preparation of cellular-active allosteric inhibitors of FAKSafety of 2-(Piperidin-4-yl)ethanol
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem