In 2017,Cheeseman, Matthew D.; Chessum, Nicola E. A.; Rye, Carl S.; Pasqua, A. Elisa; Tucker, Michael J.; Wilding, Birgit; Evans, Lindsay E.; Lepri, Susan; Richards, Meirion; Sharp, Swee Y.; Ali, Salyha; Rowlands, Martin; O’Fee, Lisa; Miah, Asadh; Hayes, Angela; Henley, Alan T.; Powers, Marissa; te Poele, Robert; De Billy, Emmanuel; Pellegrino, Loredana; Raynaud, Florence; Burke, Rosemary; van Montfort, Rob L. M.; Eccles, Suzanne A.; Workman, Paul; Jones, Keith published 《Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen》.Journal of Medicinal Chemistry published the findings.Computed Properties of C7H15NO The information in the text is summarized as follows:
Phenotypic screens, which focus on measuring and quantifying discrete cellular changes rather than measuring affinity for individual recombinant proteins, have recently attracted renewed interest as an efficient strategy for drug discovery. In this paper, the authors describe the discovery of a new chem. probe, bisamide I (CCT251236), identified using an unbiased phenotypic screen to detect inhibitors of the HSF1 stress pathway. The chem. probe is orally bioavailable and displays efficacy in a human ovarian carcinoma xenograft model. By developing cell-based SAR and using chem. proteomics, the authors identified pirin as a high affinity mol. target, which was confirmed by SPR and crystallog. In addition to this study using 2-(Piperidin-4-yl)ethanol, there are many other studies that have used 2-(Piperidin-4-yl)ethanol(cas: 622-26-4Computed Properties of C7H15NO) was used in this study.
2-(Piperidin-4-yl)ethanol(cas: 622-26-4) can be used to synthese ursolic acid derivatives, spiroimidazolidinone NPC1L1 inhibitors, neurokinin-2 receptor antagonists, antagonists for inhibition of platelet aggregation.Computed Properties of C7H15NO
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem