Synthetic Route of C13H16N2OOn September 30, 1983 ,《New antihypertensive agents. III. Synthesis and antihypertensive activity of some arylalkyl piperidines carrying a heterocycle at the 4-position》 was published in Chemical & Pharmaceutical Bulletin. The article was written by Obase, Hiroyuki; Nakamizo, Nobuhiro; Takai, Haruki; Teranishi, Masayuki; Kubo, Kazuhiro; Shuto, Katsuichi; Kasuya, Yutaka; Shigenobu, Koki; Hashikami, Makiko. The article contains the following contents:
Arylalkyl piperidines carrying a heterocycle at the 4-position of piperidine e.g. I, II, III, and IV were prepared and the hypotensive activities of the products examined Thus, 2-indolinone was treated with 1-benzyl-4-piperidinone followed by hydrogenolysis to give 4-(2-oxoindolin-3-yl)piperidine which was treated with 2-bromo-3′,4′-methylenedioxyacetophenone to give IV. Compound I had the highest hypotensive activity in anesthetized normotensive rats (-78 mmHg, 30 mg/kg, i.p.) and compound II showed the strongest hypotensive activity (-95 mmHg, 30 mg/kg p.o) in unanesthetized spontaneously hypertensive rats. Only III produced a considerable decrease in blood pressure in both animal models. In the experiment, the researchers used 3-(Piperidin-4-yl)indolin-2-one(cas: 72831-89-1Synthetic Route of C13H16N2O)
3-(Piperidin-4-yl)indolin-2-one(cas: 72831-89-1) belongs to piperidines. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions. Synthetic Route of C13H16N2O
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem