Reference of 2-(Piperidin-4-yl)ethanolIn 2022 ,《Discovery and structure-based design of a new series of potent and selective PPARδ agonists utilizing a virtual screening method》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Kato, Terukazu; Ohara, Takafumi; Suzuki, Naoyuki; Muto, Susumu; Tokuyama, Ryukou; Mizutani, Miho; Fukasawa, Hiroshi; Matsumura, Ken-ichi; Itai, Akiko. The article conveys some information:
Novel PPARδ agonists, 2-(1-piperidinyl)-1,3-benzothiazole derivatives were discovered by our proprietary docking-based virtual screening technique. Compound 1 as the initial hit was effectively modified to acquire PPARδ agonist activity, resulting in the discovery of compound 12 with high agonistic potency for PPARδ and selectivity over PPARα and PPARγ. Compound 12 also had good ADME profiles and showed in vivo efficacy as a lead. In the part of experimental materials, we found many familiar compounds, such as 2-(Piperidin-4-yl)ethanol(cas: 622-26-4Reference of 2-(Piperidin-4-yl)ethanol)
2-(Piperidin-4-yl)ethanol(cas: 622-26-4) have been used as an intermediate in the synthetic preparation of cellular-active allosteric inhibitors of FAKReference of 2-(Piperidin-4-yl)ethanol
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem