Name: TriacetonamineOn May 31, 2021, Vystorop, I. V.; Shilov, G. V.; Chernyak, A. V.; Klimanova, E. N.; Sashenkova, T. E.; Klochkov, S. G.; Neganova, M. E.; Aleksandrova, Yu. R.; Allayarova, U. Yu.; Mishchenko, D. V. published an article in Russian Journal of Bioorganic Chemistry. The article was 《Regioselective Synthesis, Structure, and Chemosensitizing Antitumor Activity of Cyclic Hydroxamic Acid Based on DL-Valine》. The article mentions the following:
The reaction of DL-valine hydroxamic acid with triacetonamine proceeds as the N,N’-regioselective condensation to form (±)-1-hydroxy-3-isopropyl-7,7,9,9-tetramethyl-1,4,8-triazaspiro[4,5]decan-2-one. A study of the antimetastatic and antitumor activities of the resulting hydroxamic acid in vivo by the combined therapy with a cytostatic of the alkylation type on a model of exptl. transplanted mouse melanoma B16 showed that the compound is capable of increasing the sensitivity of the tumor to the known antitumor drug cyclophosphamide applied at a subtherapeutic dose. The chemosensitizing activity of hydroxamic acid combined with cyclophosphamide led to an almost twofold increase in the antitumor effect of the cytostatic and a marked decrease in the number of metastases, which showed up as an increase in the metastasis inhibition index (MII) to 74%. In the experiment, the researchers used Triacetonamine(cas: 826-36-8Name: Triacetonamine)
Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Name: Triacetonamine
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem