In 2019,Molecular Nutrition & Food Research included an article by Blazenovic, Ivana; Oh, Young Taek; Li, Fan; Ji, Jian; Nguyen, Ahn-Khoi; Wancewicz, Benjamin; Bender, Jeffrey M.; Fiehn, Oliver; Youn, Jang H.. Product Details of 39546-32-2. The article was titled 《Effects of Gut Bacteria Depletion and High-Na+ and Low-K+ Intake on Circulating Levels of Biogenic Amines》. The information in the text is summarized as follows:
Scope : High-sodium and low-potassium (HNaLK) content in Western diets increases the risk of hypertension and cardiovascular disease (CVD). It is investigated if the dietary minerals interact with gut bacteria to modulate circulating levels of biogenic amines, which are implicated in various pathologies, including hypertension and CVD. Methods and results : Using a metabolomic approach to target biogenic amines, the effects of gut bacteria depletion and HNaLK intake on circulating levels of biogenic amines in rats are examined Forty-five metabolites whose plasma levels are significantly altered by gut bacteria depletion (p < 0.05) are found, indicating their regulation by gut bacteria. Many of them are not previously linked to gut bacteria; therefore, these data provide novel insights into physiol. or pathol. roles of gut bacteria. A number of plasma metabolites that are altered both by gut bacteria and HNaLK intake are also found, suggesting possible interactions of the diet and gut bacteria in the modulation of these metabolites. The diet effects are observed with significant changes in the gut bacterial taxa Porphyromonadaceae and Prevotellaceae (p < 0.05). Conclusion : The dietary minerals may regulate abundances of certain gut bacteria to alter circulating levels of biogenic amines, which may be linked to host physiol. or pathol. In the experimental materials used by the author, we found Piperidine-4-carboxamide(cas: 39546-32-2Product Details of 39546-32-2)
Piperidine-4-carboxamide(cas: 39546-32-2) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Product Details of 39546-32-2
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem