《New access to pyrano[2,3-c]pyrazole-3-carboxylates via domino four-component reaction and their antimicrobial activity》 was written by Maarop, Muhammad Siddiq; Rashid, Fatin Nur Ain Abdul; Mohammat, Mohd Fazli; Shaameri, Zurina; Johari, Saiful Azmi; Isa, Mazurah Mohamed; Low, Anis Muhammad. SDS of cas: 1445-73-4 And the article was included in Indonesian Journal of Chemistry in 2020. The article conveys some information:
A library of some novel classes of pyrano[2,3-c]pyrazole-3-carboxylates I [R = Et, i-Pr, Ph, etc.] was synthesized by employing uncatalyzed domino four-component reaction using diethyloxaloacetate, hydrazine hydrate, aldehydes and malononitrile in refluxing of ethanol-acetic acid solvent systems. Series of domino reactions involving of pyrazolone formation, Michael addition, and Thorpe-Ziegler cyclization reaction managed to produce the cyclized products I from moderate to excellent yield. This protocol provided a reliable, general and salient procedure for the title compound I using a one-pot approach. Preliminary biol. screening unveiled limited potentials of this class of compounds I for antimicrobial lead compound due to its limited solubility properties. The experimental process involved the reaction of 1-Methyl-4-piperidone(cas: 1445-73-4SDS of cas: 1445-73-4)
1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.SDS of cas: 1445-73-4
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem