In 2014,Belluti, Federica; De Simone, Angela; Tarozzi, Andrea; Bartolini, Manuela; Djemil, Alice; Bisi, Alessandra; Gobbi, Silvia; Montanari, Serena; Cavalli, Andrea; Andrisano, Vincenza; Bottegoni, Giovanni; Rampa, Angela published 《Fluorinated benzophenone derivatives: Balanced multipotent agents for Alzheimer’s disease》.European Journal of Medicinal Chemistry published the findings.Safety of 2-(Piperidin-4-yl)ethanol The information in the text is summarized as follows:
In an effort to develop multipotent agents against β-secretase (BACE-1) and acetylcholinesterase (AChE), able to counteract intracellular ROS formation as well, the structure of the fluorinated benzophenone 3 served as starting point for the synthesis of a small library of 3-fluoro-4-hydroxy- analogs. Among the series, derivatives 5 and 12, carrying chem. different amino functions, showed a balanced micromolar potency against the selected targets. In particular, compound 12, completely devoid of toxic effects, seems to be a promising lead for obtaining effective anti-AD drug candidates. The experimental process involved the reaction of 2-(Piperidin-4-yl)ethanol(cas: 622-26-4Safety of 2-(Piperidin-4-yl)ethanol)
2-(Piperidin-4-yl)ethanol(cas: 622-26-4) can be used to synthese ursolic acid derivatives, spiroimidazolidinone NPC1L1 inhibitors, neurokinin-2 receptor antagonists, antagonists for inhibition of platelet aggregation.Safety of 2-(Piperidin-4-yl)ethanol
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem