In 2019,European Journal of Medicinal Chemistry included an article by Uprety, Rajendra; Varadi, Andras; Allaoa, Abdullah; Redel-Traub, Gabriel N.; Palmer, Travis C.; Feinberg, Evan N.; Ferris, Alex C.; Pande, Vijay S.; Pasternak, Gavril W.; Majumdar, Susruta. Synthetic Route of C6H11NO. The article was titled 《Synthesis of spiro-2,6-dioxopiperazine and spiro-2,6-dioxopyrazine scaffolds using amino acids in a three-component reaction to generate potential Sigma-1 (σ1) receptor selective ligands》. The information in the text is summarized as follows:
The design and synthesis of novel heterocycles with spiro-2,6-dioxopiperazine and spiro-2,6-pyrazine scaffolds through a three-component reaction using various amino acids, ketones and isocyanides was presented. Screening of selected compounds over fifty CNS receptors including G-protein coupled receptors (GPCRs), ion channels, transporters and enzymes through the NIMH psychoactive drug screening program indicated that a novel spiro-2,6-dioxopyrazine scaffold, e.g., I, displayed high binding affinity at sigma-1 (σ1) receptor in the nanomolar range. In addition, mol. docking of spiro-2,6-dioxopyrazine scaffold, e.g., I at the human σ1 receptor showed that it resides in the same binding site that was occupied by the ligand N-(N-benzylpiperidin-4-yl)-4-iodobenzamide (4-IBP) used to obtain a crystal structure of the human sigma-1 (σ1) receptor. In the experiment, the researchers used 1-Methyl-4-piperidone(cas: 1445-73-4Synthetic Route of C6H11NO)
1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Synthetic Route of C6H11NO
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem