《Practical Synthesis of a Stable Precursor for Positron Emission Tomography Imaging Agent 18F-GTP1》 was written by White, Nicholas A.; Clagg, Kyle; Sirois, Lauren E.; Lim, Ngiap-Kie; Nack, William A.; OShea, Paul D.; Zhang, Haiming; Gosselin, Francis. Computed Properties of C7H15NO And the article was included in Organic Process Research & Development in 2020. The article conveys some information:
18F-GTP1 is a deuterated small mol. positron emission tomog. (PET) imaging agent used to visualize tau tangles in Alzheimer’s disease patients. The first-generation synthesis of 18F-GTP1’s non-radiolabeled alkyl tosylate precursor was plagued by low-yielding steps, inefficient chromatog. purifications, and variable product quality. Due to these limitations, a more robust second-generation route was developed and successfully executed on kilogram-scale. A reduction with LiAlD4 incorporated the geminal deuterium atoms, while an efficient amidation reaction accessed the key acrylamide coupling partner. Moreover, the tricyclic imidazo[1,2,a]pyrimidine core was assembled via a novel, convergent, and highly selective phosphoramidate-directed annulation. The improved synthesis eliminated all chromatog. en route to a high-yielding and reproducible acid-promoted tosylation as the final step. In the experiment, the researchers used many compounds, for example, 2-(Piperidin-4-yl)ethanol(cas: 622-26-4Computed Properties of C7H15NO)
2-(Piperidin-4-yl)ethanol(cas: 622-26-4) can be used to synthese ursolic acid derivatives, spiroimidazolidinone NPC1L1 inhibitors, neurokinin-2 receptor antagonists, antagonists for inhibition of platelet aggregation.Computed Properties of C7H15NO
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem