COA of Formula: C13H23NO4On May 15, 2009 ,《4-Piperidines and 3-pyrrolidines as dual serotonin and noradrenaline reuptake inhibitors: Design, synthesis and structure-activity relationships》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Fish, Paul V.; Andrews, Mark D.; Jonathan Fray, M.; Stobie, Alan; Wakenhut, Florian; Whitlock, Gavin A.. The article conveys some information:
A variety of [(aryloxy)(pyridinyl)methyl]piperidine and pyrrolidine derivatives are inhibitors of monoamine reuptake. Structure-activity relationships established that monoamine reuptake inhibition is a function of amine, pyridine isomer, aryloxy ring substitution and stereochem. Consequently, selective NRIs, selective SRIs, dual SNRIs and triple SNDRIs were all identified. Dual SNRIs I and II were evaluated in addnl. pharmacol. and pharmacokinetic studies as representative examples from this series. In addition to this study using (R)-1-tert-Butyl 3-ethyl piperidine-1,3-dicarboxylate, there are many other studies that have used (R)-1-tert-Butyl 3-ethyl piperidine-1,3-dicarboxylate(cas: 194726-40-4COA of Formula: C13H23NO4) was used in this study.
(R)-1-tert-Butyl 3-ethyl piperidine-1,3-dicarboxylate(cas: 194726-40-4) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.COA of Formula: C13H23NO4
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem