Peschke, Bernd; Ankersen, Michael; Hansen, Birgit Sehested; Hansen, Thomas Kruse; Johansen, Nils Langeland; Lau, Jesper; Madsen, Kjeld; Petersen, Hans; Thogersen, Henning; Watson, Brett published the artcile< Synthesis and in vitro characterization of new growth hormone secretagogues derived from ipamorelin with dipeptidomimetic N-terminals>, HPLC of Formula: 149518-50-3, the main research area is ipamorelin N terminal dipeptidomimetic derivative preparation; peptidomimetic derivative N terminal ipamorelin growth hormone secretagogue property; structure effect growth hormone secretagogue property peptidomimetic ipamorelin.
The structural requirements for N-terminal features for the minimal structure of growth hormone secretagogues derived from ipamorelin are investigated. It is found, that incorporation of nonpolar peptidomimetic amino acids at the N-terminal can replace the Aib-His moiety and lead to compounds with high in vitro potency with respect to their growth hormone secretagogue properties. New unnatural amino acids with double bonds, ether-linkages, and 1,3-phenylene-moieties in the backbone proved to be valuable dipeptidomimetics. Using them, growth hormone secretagogues with high potencies were obtained.
European Journal of Medicinal Chemistry published new progress about Peptidomimetics. 149518-50-3 belongs to class piperidines, and the molecular formula is C12H21NO4, HPLC of Formula: 149518-50-3.
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem