Kang, Zhenghui; Chang, Wenju; Tian, Xue; Fu, Xiang; Zhao, Wenxuan; Xu, Xinfang; Liang, Yong; Hu, Wenhao published their research in Journal of the American Chemical Society in 2021. The article was titled 《Ternary Catalysis Enabled Three-Component Asymmetric Allylic Alkylation as a Concise Track to Chiral α,α-Disubstituted Ketones》.Formula: C10H19NO3 The article contains the following contents:
Herein, a three-component asym. allylation of α-diazo carbonyl compounds with alcs. and allyl carbonates was disclosed by employing a ternary cooperative catalysis of achiral Pd-complex, Rh2(OAc)4, and chiral phosphoric acid CPA. This method represents the first example of three-component asym. allylic alkylation through an SN1-type trapping process, which involves a convergent assembly of two active intermediates, Pd-allyl species and enol derived from onium ylides, providing an expeditious access to chiral α,α-disubstituted ketones in good to high yields with high to excellent enantioselectivity. Combined exptl. and computational studies have shed light on the mechanism of this novel three-component reaction, including the critical role of Xantphos ligand and the origin of enantioselectivity. The experimental part of the paper was very detailed, including the reaction process of tert-Butyl 4-hydroxypiperidine-1-carboxylate(cas: 109384-19-2Formula: C10H19NO3)
tert-Butyl 4-hydroxypiperidine-1-carboxylate(cas:109384-19-2) is a 4-hydroxypyridine with a boc protecting group used in the preparation of neurologically active agents and other pharmaceutical compounds.Formula: C10H19NO3
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem