Zhai, Wenqiang; Lu, Yongping; Zhu, Yabo; Zhou, Mengguang; Ye, Cheng; Shi, Zheng-Zheng; Qian, Wenjian; Hu, Taishan; Chen, Lei published an article in 2021. The article was titled 《Discovery and optimization of a potent and selective indazolamine series of IRAK4 inhibitors》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.Category: piperidines The information in the text is summarized as follows:
IRAK4 is a key mediator of innate immunity. There is a high interest in identifying novel IRAK4 inhibitors for the treatment of inflammatory autoimmune diseases. We describe here a highly potent and selective IRAK4 inhibitor HS271 (I) that exhibited superior enzymic and cellular activities, as well as excellent pharmacokinetic properties. HS271 displayed robust in vivo anti-inflammatory efficacy as evaluated in rat models of LPS induced TNFα production and collagen-induced arthritis. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-hydroxypiperidine-1-carboxylate(cas: 109384-19-2Category: piperidines)
tert-Butyl 4-hydroxypiperidine-1-carboxylate(cas:109384-19-2) is a 4-hydroxypyridine with a boc protecting group used in the preparation of neurologically active agents and other pharmaceutical compounds.Category: piperidines
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem