《Aryl-indolyl maleimides as inhibitors of CaMKIIδ. Part 2: SAR of the amine tether》 was written by Levy, Daniel E.; Wang, Dan-Xiong; Lu, Qing; Chen, Zheng; Perumattam, John; Xu, Yong-jin; Higaki, Jeffrey; Dong, Hanmin; Liclican, Albert; Laney, Maureen; Mavunkel, Babu; Dugar, Sundeep. Electric Literature of C13H16N2 And the article was included in Bioorganic & Medicinal Chemistry Letters on April 1 ,2008. The article conveys some information:
A family of aryl-substituted maleimides was prepared and studied for their activity against calmodulin-dependant kinase. Inhibitory activities against the enzyme ranged from 34 nM to >20 μM and were dependant upon both the nature of the aryl group and the tether joining the basic amine to the indolyl maleimide core. Key interactions with the kinase ATP site and hinge region, predicted by homol. modeling, were confirmed. The experimental part of the paper was very detailed, including the reaction process of 1-(Piperidin-4-yl)-1H-indole(cas: 118511-81-2Electric Literature of C13H16N2)
1-(Piperidin-4-yl)-1H-indole(cas: 118511-81-2) belongs to piperidines. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions. Electric Literature of C13H16N2
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem