COA of Formula: C6H11NOIn 2021 ,《Design, synthesis of novel pyrazolopyridine derivatives and CREBBP bromodomain inhibitors docking and molecular dynamics》 appeared in Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry. The author of the article were Saamanthi, M.; Aruna, S.; Girija, R.; Vinod, D.. The article conveys some information:
A sequence of novel compounds pyrazolopyridines I [R = Ph, 2-phenylethenyl, 3-(trifluoromethyl)phenyl, 2,4-dimethylphenyl, etc.; X = O, S] have been prepared by a general synthetic method. Due to high efficiency and selectivity, anticancer agents consisting of combined mols. have gained great interests. The IC50 values have been determined against cell line U937, and the results obtained indicate the potential effects against cancer cell line. The cell potency of cell line is best for compounds I [R = 4-(trifluoromethyl)phenyl; X = O] IC50 = 62.5μM, I (R = Ph; X = S) IC50 = 62.5μM, I (R = Ph; X = O) IC50 = 31.2μM, I [R = 3-(trifluoromethyl)phenyl; X = O] IC50 = 31.2μM, selectivity and in vivo. Further, the mol. docking studies indicate that substituted pyrazolo[4,3-c]pyridine derivatives I show good anticancer activity in the medicinal field. The ease of synthesis and the significant biol. activities make these compounds I potential new frameworks for progress of cancer therapeutics. Compound I (R = 2,4-dimethylphenyl; X = O) shows anticancer effect in cancer cell lines and in vivo that corresponds with antitumor activity in an AML cancer type. For the mol. docking with the ligands, the RMSD value has been calculated, and the protein with the least RMSD is found to be 5KTU screening with 20 small mols. The experimental process involved the reaction of 1-Methyl-4-piperidone(cas: 1445-73-4COA of Formula: C6H11NO)
1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.COA of Formula: C6H11NO
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem