Blahun, Oleksandr P.; Melnychenko, Heorhii; Kuchkovska, Yuliya O.; Zhersh, Serhii; Tolmachev, Andrey A.; Grygorenko, Oleksandr O. published the artcile< Synthesis of Functionalized Bridged Bicyclic Sulfonamides with a Bridgehead Nitrogen Atom>, Quality Control of 91419-53-3, the main research area is dioxothiazabicycloalkanecarboxylate bridged sultam preparation.
Sultams with bridgehead nitrogen atoms such as I and II were prepared Dioxothiazabicycloalkanecarboxylic acids such as I with carboxylic acid-substituted bridgehead atoms were prepared in seven steps from Boc-protected azaheterocyclylcarbonitriles such as tert-Bu 3-cyano-1-pyrrolidinecarboxylate by chloromethylation, substitution with a thiolate, oxidative chlorination, substitution of the sulfonyl chloride with fluoride, Boc deprotection, base-mediated cyclization, and nitrile hydrolysis. Dioxothiazabicycloalkanecarboxylic acids such as I with carboxylic acid-substituted bridging atoms were prepared by carboxylation of bridged sultams [prepared in six steps by literature procedures from Boc-protected (hydroxymethyl)azacycles]. Two approaches to the synthesis of functionalized bridged bicyclic sulfonamides with a bridgehead nitrogen atom were developed. Both types of bridged sultams were prepared on > 1g scales.
European Journal of Organic Chemistry published new progress about Carboxylation. 91419-53-3 belongs to class piperidines, and the molecular formula is C11H18N2O2, Quality Control of 91419-53-3.
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem