Recommanded Product: 118511-81-2On March 1, 2014, Yang, Shyh-Ming; Tang, Yuting; Rano, Thomas; Lu, Huajun; Kuo, Gee-Hong; Gaul, Michael D.; Li, Yaxin; Ho, George; Lang, Wensheng; Conway, James G.; Liang, Yin; Lenhard, James M.; Demarest, Keith T.; Murray, William V. published an article in Bioorganic & Medicinal Chemistry Letters. The article was 《4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable stearoyl-CoA desaturase-1 (SCD1) inhibitors: Pyridazine-based analogs》. The article mentions the following:
Design, synthesis, and biol. evaluation of pyridazine-based, 4-bicyclic heteroaryl-piperidine derivatives as potent stearoyl-Co-A desaturase-1 (SCD1) inhibitors are described. In a chronic study of selected analog I in Zucker fa/fa (ZF) rat, dose-dependent decrease of body weight gain and plasma fatty acid desaturation index (DI) in both C16 and C18 are also demonstrated. The results indicate that the plasma fatty acid DI may serve as an indicator for direct target engagement and biomarker for SCD1 inhibition. The experimental process involved the reaction of 1-(Piperidin-4-yl)-1H-indole(cas: 118511-81-2Recommanded Product: 118511-81-2)
1-(Piperidin-4-yl)-1H-indole(cas: 118511-81-2) belongs to piperidines. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions. Recommanded Product: 118511-81-2
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem