With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.214834-18-1,tert-Butyl 4-carbamothioylpiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

55 mg (1.5 mmol) of 4-thiocarbamoyl-piperidine-1-tert-butyl carboxylate is added to a suspension of 57 mg (0.15 mmol) of 8-(2-bromo-acetyl)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate in 3 mL of ethanol. The mixture is stirred at 90 C. for 3 hours then the mixture is cooled to room temperature. Triethylamine (2 mmol) is added, then the solvent is evaporated and the product is purified by chromatography on silica (chloroform/methanol/triethylamine 8/2/1). After drying, 11 mg (17%) of 4-oxo-8-(2-piperidin-4-yl-thiazol-4-yl)-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate is obtained in the form of a beige solid.LCMS (IE, m/z): (M+1) 423.241H-NMR: deltaH ppm 400 MHz, DMSO11.76 (1H, bs, NH), 9.76 (1H, d, CHarom), 8.00 (1H, s, CHarom), 7.95 (1H, dd, CHarom), 7.74 (1H, s, CHarom), 7.44 (1H, d, CHarom), 4.35 (2H, q, CH2), 3.35-3.30 (1H, m, CHpiper), 3.16-3.10 (2H, m, 2¡ÁCHpiper), 2.80-2.72 (2H, m, 2¡ÁCHpiper), 2.13-2.06 (2H, m, 2¡ÁCHpiper), 1.77-1.68 (2H, m, 2¡ÁCHpiper), 1.36 (3H, t, CH3).

214834-18-1, The synthetic route of 214834-18-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Pierre Fabre Medicament; US2009/42876; (2009); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem