Related Products of 309956-78-3, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 309956-78-3, Name is (R)-tert-Butyl piperidin-3-ylcarbamate, molecular formula is C10H20N2O2. In a Article，once mentioned of 309956-78-3
We previously reported diarylurea derivatives as cannabinoid type-1 receptor (CB1) allosteric modulators, which were effective in attenuating cocaine-seeking behavior. Herein, we extended the structure-activity relationships of PSNCBAM-1 (2) at the central phenyl ring directly connected to the urea moiety. Replacement with a thiophene ring led to 11 with improved or comparable potencies in calcium mobilization, [35S]GTPI³S binding, and cAMP assays, whereas substitution with nonaromatic rings led to significant attenuation of the modulatory activity. These compounds had no inverse agonism in [35S]GTPI³S binding, a characteristic that is often thought to contribute to adverse psychiatric effects. While 11 had good metabolic stability in rat liver microsomes, it showed modest solubility and blood-brain barrier permeability. Compound 11 showed an insignificant attenuation of cocaine seeking behavior in rats, most likely due to its limited CNS penetration, suggesting that pharmacokinetics and distribution play a role in translating the in vitro efficacy to in vivo behavior.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Related Products of 309956-78-3, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 309956-78-3, in my other articles.
Reference：
Piperidine – Wikipedia,
Piperidine | C5H13298N – PubChem