Day: February 23, 2023

Identification and quantification of multi-class veterinary drugs and their metabolites in beef using LC-MS/MS was written by Jung, Young Sung;Kim, Dan-Bi;Nam, Tae Gyu;Seo, Dongwon;Yoo, Miyoung. And the article was included in Food Chemistry in 2022.HPLC of Formula: 328898-40-4 This article mentions the following:

The practice of abusing antibiotics to improve livestock growth poses a threat to food safety. To prevent and regulate this, accurate monitoring of residual veterinary drugs (VDs) is required. A method based on QuEChERS with dispersive solid-phase extraction for the determination of multi-class VDs was investigated using selected product ions under optimized multiple reaction monitoring conditions. During the clean-up procedure, chitosan, octadecyl silica, primary-secondary amine, and enhanced matrix removal (EMR)-lipid were evaluated for simultaneous anal. of multi-class VDs in beef matrix. The EMR sorbent was most advantageous (113/115) compared to others, and showed a satisfactory recovery range (70.7-117.9%) except cefquinome (67.3%) and cefalonium (69.8%). This methodol. can be used to detect oxolinic acid and ractopamine (27.4% and 88.0% of maximum residue limit, resp.) in real beef samples. We thus study propose a simple and fast anal. method for multi-class VDs for the future health of humans and animals. In the experiment, the researchers used many compounds, for example, (4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-(((2R,3R,4S,5S,6R)-4-(Dimethylamino)-3,5-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-16-ethyl-4-hydroxy-5,9,13-trimethyl-7-(2-(piperidin-1-yl)ethyl)-15-(piperidin-1-ylmethyl)oxacyclohexadeca-11,13-diene-2,10-dione (cas: 328898-40-4HPLC of Formula: 328898-40-4).

(4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-(((2R,3R,4S,5S,6R)-4-(Dimethylamino)-3,5-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-16-ethyl-4-hydroxy-5,9,13-trimethyl-7-(2-(piperidin-1-yl)ethyl)-15-(piperidin-1-ylmethyl)oxacyclohexadeca-11,13-diene-2,10-dione (cas: 328898-40-4) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.HPLC of Formula: 328898-40-4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Piper retrofractum extract and its component piperine promote lymphangiogenesis via an AKT – and ERK -dependent mechanism was written by Ishii, Masakazu;Miyata, Haruka;Ikeda, Nao;Tagawa, Takashi;Nishimura, Masahiro. And the article was included in Journal of Food Biochemistry in 2022.Recommanded Product: (2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one This article mentions the following:

Administration of Piper retrofractum extract (PRE) has been reported to alleviate edema, but the mechanism underlying this effect is unknown. Promotion of lymphangiogenesis is known to improve lymphedema, but the effect of PRE on lymphangiogenesis remains unclear. In the present study, we investigated whether PRE and specifically, piperine, the main component of PRE, can induce lymphangiogenesis. Treatments with PRE and piperine significantly promoted the proliferation, migration, and tube formation in human dermal lymphatic microvascular endothelial cells (HDLECs) but had no effect on the expression of lymphangiogenic factors. Furthermore, PRE and piperine significantly promoted the phosphorylation of the AKT and ERK proteins in HDLECs, and pretreatment with AKT and ERK inhibitors significantly attenuated the PRE- and piperine-induced lymphangiogenesis. These results indicate that PRE and piperine promote lymphangiogenesis via an AKT- and ERK-dependent mechanism. Practical applications : The lymphatic system plays various roles such as maintaining tissue fluid homeostasis, immune defense, and metabolism Disruption of the lymphatic system results in insufficient fluid drainage, which causes edema. Currently, there are no effective treatments for lymphedema; therefore, the development of novel treatment strategies is desirable. In this study, we showed that PRE and its main component piperine promote lymphangiogenesis in lymphatic endothelial cells. Therefore, PRE has the potential to be used as a novel functional food for relieving lymphedema. In the experiment, the researchers used many compounds, for example, (2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one (cas: 94-62-2Recommanded Product: (2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one).

(2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one (cas: 94-62-2) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Recommanded Product: (2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In Silico and In Vitro Studies of the Inhibitory Effect of Antihistamine Drug Cyproheptadine Hydrochloride on Human Salivary Alpha Amylase was written by Madjda, Benguechoua;Khedidja, Benarous;Samira, Nia;Mohamed, Yousfi. And the article was included in Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry in 2021.Recommanded Product: 4-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine hydrochloride This article mentions the following:

For the first time, the inhibitory effects on the human salivary alpha-amylase activity of the anti-inflammatory drugs indomethacin, diclofenac sodium, ketoprofen, diclofenac potassium, diclofenac, triamcinolone acetonide, and the antihistamine drugs levocetirizine dihydrochloride, desloratadine, cycloheptadine hydrochloride, have been investigated to confirm the other properties of these drugs. This study aimed to determine the effect of nine known drugs on human salivary a-amylase in vitro and the nature of interactions with structure-activity relationship using mol. docking experiments The inhibition of human salivary alpha amylase by the six anti-inflammatory and three antihistamine drugs has been carried out using the new method that has been proved in our previous work. Mol. docking has been achieved for the first time for these drugs using the Auto- Dock Vina program. Cyproheptadine hydrochloride presented the highest inhibitory activity against a-amylase with IC₅₀ = 0.7 mg/mL, while the other drugs showed weak activities (IC₅₀ > 2 mg/mL). We conclude that Cyproheptadine hydrochloride, which was studied by docking experiments, exhibited the best inhibitory activity on salivary a-amylase in vitro & in silico. In the experiment, the researchers used many compounds, for example, 4-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine hydrochloride (cas: 969-33-5Recommanded Product: 4-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine hydrochloride).

4-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine hydrochloride (cas: 969-33-5) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Recommanded Product: 4-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine hydrochloride

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Method development and validation of fexofenadine hydrochloride in bulk and solid dosage form (tablets) by UV-visible spectrophotometry was written by Rojarani, B.;Swamy, D. Kumara. And the article was included in International Journal of Pharmacy and Pharmaceutical Research in 2022.Related Products of 153439-40-8 This article mentions the following:

A simple, accurate, and sensitive method was developed and validated for the determination of Fexofenadine hydrochloride (FEX.HCl) in bulk and tablet formulation. The method is based on the reaction of FEX.HCl with Di cyclohexyl carbodiimide (DCC) and 2-Nitrophenyl hydrazine (2-NPH) in solution, forms 2-Nitrophenyl hydrazide of Fexofenadine hydrochloride. Using ethanol as a solvent, and subsequently measured spectrophotometrically at 415nm. The reaction was extremely rapid at room temperature and absorbance values remained unchanged for at least 24h. Beer’s law was obeyed in the concentration range of 10-60μg/Ml within the detection limit of 0.62 and 0.68μg/mL and limit of quantification of 1.88 and 2.06μg/mL for FEX.HCl bulk and tablet derivatives resp. The anal. method was validated according to ICH guidelines. The correlation coefficient (r2) was found to be 0.999 and 0.998, % recovery was found to be 100.1 and 99.9, %RSD for repeatability was found to be 1.324 and 0.7824 (intraday), 1.365 and 0.7015 (interday), %RSD for intermediate precision for analyst 1 was found to be 0.435 & 0.520, for analyst 2%RSD was found to be 0.437 & 0.522 for FEX.HCl bulk and tablet derivatives resp. The robustness results of derivatives of FEX.HCl in bulk and tablets (20μg/mL) was performed by changing wavelengths and no noticeable changes were found on small changes in wavelength. Hence the method was found to be robust. The results obtained were compared statistically with those obtained by the official method and showed no significant differences regarding accuracy, precision & other anal. parameters. In the experiment, the researchers used many compounds, for example, 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride (cas: 153439-40-8Related Products of 153439-40-8).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride (cas: 153439-40-8) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Related Products of 153439-40-8

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Ring-Opening Polymerization with Lewis Pairs and Subsequent Nucleophilic Substitution: A Promising Strategy to Well-Defined Polyethylene-like Polyesters without Transesterification was written by Wang, Bin;Pan, Li;Ma, Zhe;Li, Yuesheng. And the article was included in Macromolecules (Washington, DC, United States) in 2018.Synthetic Route of C10H21N This article mentions the following:

Ring-opening polymerization (ROP) of ω-pentadecalactone (PDL) catalyzed by Lewis pairs was thoroughly explored, and a novel approach to well-defined aliphatic long chain polyester with high mol. weight (MW) was developed in the present work. The Zn(C₆F₅)₂/1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) Lewis pair was proved to be a promising catalytic system for ROP of PDL, producing cyclic PPDL with high MW (M_w > 100 kg/mol) and relatively low polydispersity index (M_w/M_n = 1.6-1.9). Strikingly, no transesterification occurred in the ROP of PDL by Zn(C₆F₅)₂/DBU. The cyclic topol. of the polyester could be switched to linear structure in the presence of alc. The feeding mode and the structure of alc. significantly influence the ROP. Compared with mixing alc. with Zn(C₆F₅)₂/DBU at first, adding Ph₂CHOH with low nucleophilicity after full monomer conversion could afford linear PPDL without transesterification. It was noted that random chain scission or chain extension was not detected after adding Ph₂CHOH. Well-defined block copolymer containing polyethylene-like segment can be easily prepared by sequential addition of PDL and lactide (LA) or caprolactone (CL). Cyclic block copolyesters c-poly(PDL-b-CL) and c-poly(PDL-b-LA) were obtained in the absence of alc. The blocky structures can be maintained even when prolonging reaction time after full monomer conversion. Similarly, introducing Ph₂CHOH before quenching the polymerization led to well-defined linear block copolyesters l-poly(PDL-b-CL) and l-poly(PDL-b-LA). In the experiment, the researchers used many compounds, for example, 1,2,2,6,6-Pentamethylpiperidine (cas: 79-55-0Synthetic Route of C10H21N).

1,2,2,6,6-Pentamethylpiperidine (cas: 79-55-0) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising α-glucosidase inhibitors. The former are analogs of DNJ with an improved α-glucosidase inhibitory profile than that of DNJ. Boisson et al.Synthetic Route of C10H21N

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Influence of experimental conditions on the electrochemical window. Case study on bis(trifluoromethylsulfonyl)imide-based ionic liquids was written by Gancarz, Pawel;Zorebski, Edward;Dzida, Marzena. And the article was included in Electrochemistry Communications in 2021.Product Details of 608140-12-1 This article mentions the following:

Ionic liquids (ILs) are often selected as electrolytes in various devices, such as batteries, capacitors and sensors, because of their chem. stability, non-flammability, low volatility, high elec. conductivity, low m.p., high thermal stability, and wide electrochem. window (EW). The width of the EW of an IL depends on the cation type, the water content, the electrode material, and the chosen specific c.d. used to measure it. In this work, the EWs of four ILs containing the common and stable bis(trifluoromethylsulfonyl)imide anion and triethylsulfonium, 1-(2-hydroxyethyl)-3-methylimidazolium, 1-methyl-1-propylpiperidinium and 1-butyl-1-methylpiperidinium cations were investigated by linear sweep voltammetry in order to analyze their electrochem. stability toward reduction and oxidation at polycrystalline platinum, gold and glassy carbon disc electrodes under anhydrous conditions. Specific current densities of 0.1 mA·cm^-2 or 1 mA·cm^-2 or the linear fitting method were used for the systematic comparison of the EWs obtained from each dataset. The results indicate the dependence of the EW width of each IL on the electrode material and, more importantly, on the chosen specific c.d. In this paper, we present new insight into some of the difficulties encountered during determination of the EW for ILs. In the experiment, the researchers used many compounds, for example, 1-Methyl-1-propylpiperidin-1-ium bis((trifluoromethyl)sulfonyl)amide (cas: 608140-12-1Product Details of 608140-12-1).

1-Methyl-1-propylpiperidin-1-ium bis((trifluoromethyl)sulfonyl)amide (cas: 608140-12-1) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Product Details of 608140-12-1

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Concerted Amidation of Activated Esters: Reaction Path and Origins of Selectivity in the Kinetic Resolution of Cyclic Amines via N-Heterocyclic Carbenes and Hydroxamic Acid Cocatalyzed Acyl Transfer was written by Allen, Scott E.;Hsieh, Sheng-Ying;Gutierrez, Osvaldo;Bode, Jeffrey W.;Kozlowski, Marisa C.. And the article was included in Journal of the American Chemical Society in 2014.Recommanded Product: 1722-95-8 This article mentions the following:

The N-heterocyclic carbene and hydroxamic acid cocatalyzed kinetic resolution of cyclic amines generates enantioenriched amines and amides with selectivity factors up to 127. In this report, a quantum mech. study of the reaction mechanism indicates that the selectivity-determining aminolysis step occurs via a novel concerted pathway in which the hydroxamic acid plays a key role in directing proton transfer from the incoming amine. This modality was found to be general in amide bond formation from a number of activated esters including those generated from HOBt and HOAt, reagents that are broadly used in peptide coupling. For the kinetic resolution, the proposed model accurately predicts the faster reacting enantiomer. A breakdown of the steric and electronic control elements shows that a gearing effect in the transition state is responsible for the observed selectivity. In the experiment, the researchers used many compounds, for example, (R)-2-Methylpiperidine (cas: 1722-95-8Recommanded Product: 1722-95-8).

(R)-2-Methylpiperidine (cas: 1722-95-8) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising α-glucosidase inhibitors. The former are analogs of DNJ with an improved α-glucosidase inhibitory profile than that of DNJ. Boisson et al.Recommanded Product: 1722-95-8

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Piperidine scaffold as the novel P2-ligands in cyclopropyl-containing HIV-1 protease inhibitors: Structure-based design, synthesis, biological evaluation and docking study was written by Zhou, Huiyu;Zhu, Mei;Ma, Ling;Zhou, Jinming;Dong, Biao;Zhang, Guoning;Cen, Shan;Wang, Yucheng;Wang, Juxian. And the article was included in PLoS One in 2020.Electric Literature of C11H19NO4 This article mentions the following:

A series of potent HIV-1 protease inhibitors, containing diverse piperidine analogs as the P2-ligands, 4-substituted phenylsulfonamides as the P2′-ligands and a hydrophobic cyclopropyl group as the P1′-ligand, were designed, synthesized and evaluated in this work. Among these twenty-four target compounds, many of them exhibited excellent activity against HIV-1 protease with half maximal inhibitory concentration (IC₅₀) values below 20 nM. Particularly, compound I containing a (R)-piperidine-3-carboxamide as the P2-ligand and a 4-methoxylphenylsulfonamide as the P2′-ligand exhibited the most effective inhibitory activity with an IC₅₀ value of 3.61 nM. More importantly, I exhibited activity with inhibition of 42% and 26% against wild-type and Darunavir (DRV)-resistant HIV-1 variants, resp. Addnl., the mol. docking of I with HIV-1 protease provided insight into the ligand-binding properties, which was of great value for further study. In the experiment, the researchers used many compounds, for example, (R)-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid (cas: 163438-09-3Electric Literature of C11H19NO4).

(R)-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid (cas: 163438-09-3) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Electric Literature of C11H19NO4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

One-pot conversion of alkyl aldehydes into substituted propanoic acids via Knoevenagel condensation with Meldrum’s acid was written by Mudhar, Harminder;Witty, Andrew. And the article was included in Tetrahedron Letters in 2010.Recommanded Product: 138163-08-3 This article mentions the following:

Reaction of a range of alkyl aldehydes and Meldrum’s acid in triethylammonium formate (TEAF) at 100°C generated substituted propanoic acids in a single step. In the experiment, the researchers used many compounds, for example, Benzyl 4-formylpiperidine-1-carboxylate (cas: 138163-08-3Recommanded Product: 138163-08-3).

Benzyl 4-formylpiperidine-1-carboxylate (cas: 138163-08-3) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Recommanded Product: 138163-08-3

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Organocatalytic chemoselective monoacylation of 1,n-linear disulfonamides was written by Yoshida, Keisuke;Hirata, Atsushi;Hashimoto, Hisashi;Imayoshi, Ayumi;Ueda, Yoshihiro;Furuta, Takumi;Kawabata, Takeo. And the article was included in Tetrahedron Letters in 2017.Name: 1,2,2,6,6-Pentamethylpiperidine This article mentions the following:

Predominant monoacylation of 1,n-linear disulfonamides took place in the presence of pyrrolidinopyridine-type organocatalysts when the chain length of the linear disulfonamides was n = 3, 4, or 5 (monoacylate/diacylate = up to 44). The chemoselectivity of the competitive acylation between N,N’-ditosyl-1,5-pentanediamine (n = 5) and N,N’-ditosyl-1,3-propanediamine (n = 3) was found to be 36, favoring the former substrate. Different chain length by only one carbon atom was discriminated in the competitive acylation between N,N’-ditosyl-1,5-pentanediamine (n = 5) and of N,N’-ditosyl-1,4-butanediamine (n = 4) with the relative acylation rate of 16 in the presence of the organocatalyst. In the experiment, the researchers used many compounds, for example, 1,2,2,6,6-Pentamethylpiperidine (cas: 79-55-0Name: 1,2,2,6,6-Pentamethylpiperidine).

1,2,2,6,6-Pentamethylpiperidine (cas: 79-55-0) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Name: 1,2,2,6,6-Pentamethylpiperidine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem