Day: February 22, 2023

Asymmetric Cross-Dehydrogenative Coupling Enabled by the Design and Application of Chiral Triazole-Containing Phosphoric Acids was written by Neel, Andrew J.;Hehn, Jorg P.;Tripet, Pascal F.;Toste, F. Dean. And the article was included in Journal of the American Chemical Society in 2013.Product Details of 219543-09-6 This article mentions the following:

Nonracemic triazolylbinaphthylphosphoric acids I [R = PhCH₂, Ph₂CH, bis(1-naphthyl)methyl, 1-naphthyl, 9-anthracenyl, 1-pyrenyl, 2,4,6-Me₃C₆H₂, 2,4,6-i-Pr₃C₆H₂, 2,4,6-(c-C₆H₁₁)₃C₆H₂, 4-t-BuC₆H₄, 3,5-t-Bu₂C₆H₃, 1-adamantyl] were prepared using azide-alkyne cycloadditions of a protected diethynylbinaphthol with azides RN₃ [R = PhCH₂, Ph₂CH, bis(1-naphthyl)methyl, 1-naphthyl, 9-anthracenyl, 1-pyrenyl, 2,4,6-Me₃C₆H₂, 2,4,6-i-Pr₃C₆H₂, 2,4,6-(c-C₆H₁₁)₃C₆H₂, 4-t-BuC₆H₄, 3,5-t-Bu₂C₆H₃, 1-adamantyl]; in the presence of I, an acetamidopiperidineoxoammonium salt, and trisodium phosphate in p-xylene, tetrahydroisoquinolinylbenzamides II [R¹ = PhCH₂, 4-MeC₆H₄CH₂, 4-MeOC₆H₄CH₂, 4-O₂NC₆H₄CH₂, 2-MeOC₆H₄CH₂, Ph, 3-MeC₆H₄, 2-MeC₆H₄, 1-naphthyl, 2-ClC₆H₄, 2-HOC₆H₄, t-Bu, cyclohexyl, (R)-MeO₂CCH(i-Pr), (S)-MeO₂CCH(i-Pr); R² = H, Me, Br, F₃C] underwent enantioselective cross-dehydrogenative coupling reactions to give tetrahydroisoquinolinoquinazolinones III [R¹ = PhCH₂, 4-MeC₆H₄CH₂, 4-MeOC₆H₄CH₂, 4-O₂NC₆H₄CH₂, 2-MeOC₆H₄CH₂, Ph, 3-MeC₆H₄, 2-MeC₆H₄, 1-naphthyl, 2-ClC₆H₄, 2-HOC₆H₄, t-Bu, cyclohexyl, (R)-MeO₂CCH(i-Pr), (S)-MeO₂CCH(i-Pr); R² = H, Me, Br, F₃C] in 38-93% yields and in 73-93% ee or in 3:1-7:1 dr. I were designed to use attractive hydrogen-bonding interactions with substrates rather than catalyst steric bulk to improve the stereoselectivity of the coupling reaction. The azides used in the preparation of I are potentially explosive and should be handled and reacted using appropriate precautions. In the experiment, the researchers used many compounds, for example, 4-Acetamido-2,2,6,6-tetramethyl-1-oxopiperidinium Tetrafluoroborate (cas: 219543-09-6Product Details of 219543-09-6).

4-Acetamido-2,2,6,6-tetramethyl-1-oxopiperidinium Tetrafluoroborate (cas: 219543-09-6) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising α-glucosidase inhibitors. The former are analogs of DNJ with an improved α-glucosidase inhibitory profile than that of DNJ. Boisson et al.Product Details of 219543-09-6

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

¹H NMR Chiral Analysis of Charged Molecules via Ion Pairing with Aluminum Complexes was written by Seo, Min-Seob;Kim, Hyunwoo. And the article was included in Journal of the American Chemical Society in 2015.Electric Literature of C6H13N This article mentions the following:

Chiral anal., such as determination of identity, concentration, and relative ratio of optically active (chiral) mols., plays an indispensable role in contemporary synthetic, medicinal, and biol. chem. Here, we describe the selective control of metal-centered chirality in an octahedral geometry to prepare neg. charged Al^III complexes, which can be used as versatile ¹H NMR chiral solvating agents for both pos. and neg. charged chiral mols. in polar or nonpolar solvents. During the formation of ion pairs between the Al^III complexes and the chiral analytes such as amines and carboxylic acids, the metal-centered chirality in the Al complexes plays a crucial role in providing anisochronous chem. shifts to the ¹H NMR spectra. As a chiral solvating agent, Al^III complexes display an unprecedentedly broad substrate scope, good solvent compatibility, and operational simplicity. In the experiment, the researchers used many compounds, for example, (R)-2-Methylpiperidine (cas: 1722-95-8Electric Literature of C6H13N).

(R)-2-Methylpiperidine (cas: 1722-95-8) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising α-glucosidase inhibitors. The former are analogs of DNJ with an improved α-glucosidase inhibitory profile than that of DNJ. Boisson et al.Electric Literature of C6H13N

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Thermo-sensitive and swelling properties of cellouronic acid sodium/poly (acrylamide-co-diallyldimethylammonium chloride) semi-IPN was written by Zhang, Heng;Gao, Xin;Chen, Keli;Li, Hui;Peng, Lincai. And the article was included in Carbohydrate Polymers in 2018.Category: piperidines This article mentions the following:

In current study, celluronic acid sodium (CAS), obtained from bagasse pith, has been introduced into poly(acrylamide-co-diallyldimethylammonium chloride) (poly(AM-co-DAC)) network to form novel thermo-sensitive semi-IPNs. The structure and morphol. of the hydrogels were proved by Fourier transformation IR spectroscopy (FT-IR), XPS and SEM (SEM). The effects of CAS content, initiator charge, cross-linker dosage and swelling-medium property on the thermo-responsive water absorptivity were investigated in detail. The results elucidated that the prepared gels exhibited a thermo-sensibility with an upper critical solution temperature (UCST) and a high water-absorbency. And the values of UCST and equilibrium swelling ratio largely depended on the inner structure of the semi-IPNs and the external solvent property. It was also revealed that the swelling process conformed to the Schott’s pseudo second order model and diffusion type was non-Fickian diffusion. The value of activation energy for this polyelectrolyte was found to be 8.74 kJ/mol. In the experiment, the researchers used many compounds, for example, 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl (cas: 14691-89-5Category: piperidines).

4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl (cas: 14691-89-5) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

P(III)-Assisted Electrochemical Access to Ureas via in situ Generation of Isocyanates from Hydroxamic Acids was written by Meng, Haiwen;Sun, Kunhui;Xu, Zhimin;Tian, Lifang;Wang, Yahui. And the article was included in European Journal of Organic Chemistry in 2021.Application of 1126-09-6 This article mentions the following:

An external oxidant-free protocol for the generation of isocyanates from hydroxamic acids assisted by trivalent phosphine under mild electrochem. conditions was reported. The process started with the anodic oxidation of hydroxamic acids, followed by reacting with phosphine to form corresponding alkoxyphosphoniums and subsequent rearrangement with the release of tri-substituted phosphine oxide as the driving force to give isocyanates, which were trapped by N-based nucleophiles to produce various ureas. This method provides a broadly applicable procedure to access isocyanate intermediates under mild electrochem. conditions. In the experiment, the researchers used many compounds, for example, Ethyl piperidine-4-carboxylate (cas: 1126-09-6Application of 1126-09-6).

Ethyl piperidine-4-carboxylate (cas: 1126-09-6) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising α-glucosidase inhibitors. The former are analogs of DNJ with an improved α-glucosidase inhibitory profile than that of DNJ. Boisson et al.Application of 1126-09-6

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Carbon Negative Electrodes for Li-Ion Batteries: The Effect of Solutions and Temperatures was written by Yariv, Ortal;Hirshberg, Daniel;Zinigrad, Ella;Meitav, Arye;Aurbach, Doron;Jiang, Meng;Powell, Bob R.. And the article was included in Journal of the Electrochemical Society in 2014.Quality Control of 1-Methyl-1-propylpiperidin-1-ium bis((trifluoromethyl)sulfonyl)amide This article mentions the following:

In this paper we report on the behavior of some carbonaceous materials as anodes for Li ion batteries in several selected electrolyte solutions and over a wide range of temperatures, from -30° to 45°. The solution components studied include alkyl carbonates (ethylene carbonate (EC), di-Me carbonate (DMC)) mono-fluorinated and bi-fluorinated ethylene carbonates (FEC, 2FEC), vinylene carbonate (VC), diglyme, LiPF₆ and LiN(SO₂CF₃)₂ (LiTFSI). While standard electrolyte solutions for Li ion batteries based on EC-DMC-LiPF₆ have poor specific conductivity at low temperatures, diglyme/LiTFSI, VC (2%)-EC-DMC, FEC-DMC and 2FEC-DMC with LiPF₆ exhibit reasonable conductivities (>2 mS/cm) at -30°. Graphitic materials exhibit poor low temperature performance, while soft carbons behave better at low temperatures It was found that FEC-DMC/LiPF₆ solutions are very suitable for carbon electrodes over a wide temperature domain. In fact, using these solutions enables soft carbon electrodes to demonstrate higher specific capacity than graphite electrodes below 0°, although the room temperature specific capacity of graphite is 1.5 times higher than that of soft carbon. In the experiment, the researchers used many compounds, for example, 1-Methyl-1-propylpiperidin-1-ium bis((trifluoromethyl)sulfonyl)amide (cas: 608140-12-1Quality Control of 1-Methyl-1-propylpiperidin-1-ium bis((trifluoromethyl)sulfonyl)amide).

1-Methyl-1-propylpiperidin-1-ium bis((trifluoromethyl)sulfonyl)amide (cas: 608140-12-1) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Quality Control of 1-Methyl-1-propylpiperidin-1-ium bis((trifluoromethyl)sulfonyl)amide

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Pyrrolo[3,2-c]pyridine derivatives as inhibitors of platelet aggregation was written by Altomare, C.;Summo, L.;Cellamare, S.;Varlamov, A. V.;Voskressensky, L. G.;Borisova, T. N.;Carotti, A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2000.Safety of 1-Benzylpiperidin-4-one oxime This article mentions the following:

A series of pyrrolo[3,2-c]pyridines, isosteres of the antithrombotic drug ticlopidine, has been synthesized and evaluated in vitro for the ability to inhibit aggregation of human platelet-rich plasma induced by ADP. Structure-activity relationships showed their antiplatelet effects to be related to the lipophilicity. In the experiment, the researchers used many compounds, for example, 1-Benzylpiperidin-4-one oxime (cas: 949-69-9Safety of 1-Benzylpiperidin-4-one oxime).

1-Benzylpiperidin-4-one oxime (cas: 949-69-9) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Safety of 1-Benzylpiperidin-4-one oxime

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Solid-phase synthesis of 3-aminohydantoin, dihydrouracil, thiohydantoin and dihydrothiouracil derivatives was written by Wu, Shengde;Janusz, John M.. And the article was included in Tetrahedron Letters in 2000.Product Details of 25560-00-3 This article mentions the following:

An efficient and convenient route to 3-aminohydantoins and dihydrouracils using solid-phase chem. has been developed. This methodol. has the advantage of generality and diversity over solution-phase chem. for the preparation of 3-aminohydantoins and dihydrouracils. In the experiment, the researchers used many compounds, for example, 3-(2-Methylpiperidin-1-yl)propan-1-amine (cas: 25560-00-3Product Details of 25560-00-3).

3-(2-Methylpiperidin-1-yl)propan-1-amine (cas: 25560-00-3) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Product Details of 25560-00-3

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

UiO-type metal-organic frameworks with NHC or metal-NHC functionalities for N-methylation using CO₂ as the carbon source was written by Zhang, Xu;Jiang, Yilin;Fei, Honghan. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.COA of Formula: C10H21N This article mentions the following:

The first metal-organic framework (MOF) catalyzed N-methylation of amines using 1 atm CO₂ and phenylsilane under ambient conditions was reported. Compared with its homogeneous analog, the incorporation of N-heterocyclic carbene (NHC) into the MOF provided more efficient catalysis with improved reaction kinetics, turnover numbers and recyclability. Moreover, the metalated NHC functionalized MOF achieved direct N-methylation of amines bearing carboxylate moieties, which were common building blocks in pharmaceutical chem. In the experiment, the researchers used many compounds, for example, 1,2,2,6,6-Pentamethylpiperidine (cas: 79-55-0COA of Formula: C10H21N).

1,2,2,6,6-Pentamethylpiperidine (cas: 79-55-0) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.COA of Formula: C10H21N

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Determination of cyproheptadine hydrochloride in pure and pharmaceutical forms : a spectrophotometric study was written by Sayanna;Veeraiah, T.;Reddy, Ch. Venkata Ramana. And the article was included in Oriental Journal of Chemistry in 2015.Application of 969-33-5 This article mentions the following:

Siimple and sensitive extractive spectrophotometric methods have been described for the determination of Cyproheptadine hydrochloride (CPH) in pure form and in pharmaceutical formulations. The developed methods involved formation of colored chloroform extractable ion-pair complexes of the CPH with tri-Ph methane dyes viz., bromothymol blue (BTB), bromocresol green (BCG) and bromocresol purple (BCP) in acidic medium. The extracted complexes showed absorbance maxima at 419, 419 and 405nm with use of the above dyes, resp. Beer’s law is obeyed in the concentration ranges 3.0-25, 2.5-22.5 and 1.5-25μg/mL with BTB, BCG and BCP resp. The stoichiometry of the complex is found to be 1:1 in each case. The effect of concentration of dye, pH and interference of excipients have been studied and optimized. The limit of detection and limit of quantification have been determined for three methods. The methods are applied to the determination of CPH in com. tablets and results of anal. are validated statistically through recovery studies also the methods are validated as per the guidelines of ICH. In the experiment, the researchers used many compounds, for example, 4-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine hydrochloride (cas: 969-33-5Application of 969-33-5).

4-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine hydrochloride (cas: 969-33-5) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Application of 969-33-5

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Ultrasound Treatment Enhanced Semidry-Milled Rice Flour Properties and Gluten-Free Rice Bread Quality was written by Qin, Wanyu;Xi, Huihan;Wang, Aixia;Gong, Xue;Chen, Zhiying;He, Yue;Wang, Lili;Liu, Liya;Wang, Fengzhong;Tong, Litao. And the article was included in Molecules in 2022.Application In Synthesis of 4-Oxo-tempo This article mentions the following:

The structural and functional properties of phys. modified rice flour, including ultrasound treated rice flour (US), microwave treated rice flour (MW) and hydrothermal treated rice flour (HT) were investigated with wet-milled rice flour (WF) used as a pos. control. The results showed the presence of small dents and pores on the rice flour granules of US and MW while more fragments and cracks were showed in HT. XRD and FTIR revealed that moderate ultrasonic treatment promoted the orderly arrangement of starch while hydrothermal treatment destroyed the crystalline structure of rice flour. In addition, the significant decrease of gelatinization enthalpy and the narrowing gelatinization temperature were observed in US. Compared to that of SF, adding phys. modified rice flour led to a batter with higher viscoelasticity and lower tan δ. However, the batter added HT exhibited highest G ‘ and G” values and lowest tan δ, which led to a harder texture of bread. Texture anal. demonstrated that phys. modified rice flour (except HT) reduced the hardness, cohesion, and gumminess of rice bread. Especially, the sp. volume of bread with US increased by 15.6% and the hardness decreased by 17.6%. This study suggested that ultrasound treatment of rice flour could improve texture properties and appearance of rice bread. In the experiment, the researchers used many compounds, for example, 4-Oxo-tempo (cas: 2896-70-0Application In Synthesis of 4-Oxo-tempo).

4-Oxo-tempo (cas: 2896-70-0) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Application In Synthesis of 4-Oxo-tempo

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem