Day: February 22, 2023

Reversible thermochromism, temperature-dependent conductivity and high stability for a laminated bismuth(III)-silver(I) hybrid double perovskite was written by Lassoued, Mohamed Saber;Wang, Tengbo;Faizan, Ahmad;Li, Qian-Wen;Chen, Wei-Peng;Zheng, Yan-Zhen. And the article was included in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2022.Safety of 4-Amino-1-methylpiperidine This article mentions the following:

Lead-free hybrid perovskite materials have attracted tremendous consideration due to their applications in photovoltaics, optoelectronics, thermal sensors, etc. Herein, we isolated a new stable semiconductive 2D bismuth(III)-silver(I) iodide hybrid double perovskite formulated as (H₂MPP)₂[BiAgI₈], where H₂MPP = 1-methylpiperidinium-4-amine, with reversible solid-state thermochromism, a narrow bandgap and considerable temperature-dependent conductivity Upon heating from 150 K to 450 K, (H₂MPP)_2[BiAgI₈] crystals exhibit a reversible color change between orange and dark red. The associated structural changes were monitored using in situ single-crystal X-ray diffraction (SCXRD), powder X-ray diffraction (PXRD), UV-visible absorption and Raman spectroscopy. Besides, the elec. conductivity of (H₂MPP)₂[BiAgI₈] changes over four orders of magnitude upon thermochromism (up to 1.51 x 10^-6 S cm^-1 at 450 K) and showed an efficiently enhanced photocurrent switching on/off ratio. Moreover, the (H₂MPP)₂[BiAgI₈] crystals can be processed into thin films via spin coating and exhibit high stability under heat and moisture, which is indicative of their potential optoelectronic applications based on thermochromism. In the experiment, the researchers used many compounds, for example, 4-Amino-1-methylpiperidine (cas: 41838-46-4Safety of 4-Amino-1-methylpiperidine).

4-Amino-1-methylpiperidine (cas: 41838-46-4) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Safety of 4-Amino-1-methylpiperidine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2 was written by Morita, Ken;He, Shuning;Nowak, Radoslaw P.;Wang, Jinhua;Zimmerman, Mark W.;Fu, Cong;Durbin, Adam D.;Martel, Megan W.;Prutsch, Nicole;Gray, Nathanael S.;Fischer, Eric S.;Look, A. Thomas. And the article was included in Cell (Cambridge, MA, United States) in 2020.Recommanded Product: 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine This article mentions the following:

Protein phosphatase 2A (PP2A) enzymes can suppress tumors, but they are often inactivated in human cancers overexpressing inhibitory proteins. Here, we identify a class of small-mol. iHAPs (improved heterocyclic activators of PP2A) that kill leukemia cells by allosterically assembling a specific heterotrimeric PP2A holoenzyme consisting of PPP2R1A (scaffold), PPP2R5E (B56ε, regulatory), and PPP2CA (catalytic) subunits. One compound, iHAP1, activates this complex but does not inhibit dopamine receptor D2, a mediator of neurol. toxicity induced by perphenazine and related neuroleptics. The PP2A complex activated by iHAP1 dephosphorylates the MYBL2 transcription factor on Ser241, causing irreversible arrest of leukemia and other cancer cells in prometaphase. In contrast, SMAPs, a sep. class of compounds, activate PP2A holoenzymes containing a different regulatory subunit, do not dephosphorylate MYBL2, and arrest tumor cells in G1 phase. Our findings demonstrate that small mols. can serve as allosteric switches to activate distinct PP2A complexes with unique substrates. In the experiment, the researchers used many compounds, for example, 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine (cas: 50-52-2Recommanded Product: 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine).

10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine (cas: 50-52-2) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Recommanded Product: 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Search for ABO₃ Type Ferroelectric Perovskites with Targeted Multi-Properties by Machine Learning Strategies was written by Xu, Pengcheng;Chang, Dongping;Lu, Tian;Li, Long;Li, Minjie;Lu, Wencong. And the article was included in Journal of Chemical Information and Modeling in 2022.Category: piperidines This article mentions the following:

Ferroelec. perovskites are one of the most promising functional materials due to the pyroelec. and piezoelec. effect. In the practical applications of ferroelec. perovskites, it is often necessary to meet the requirements of multiple properties. In this work, a multiproperties machine learning strategy was proposed to accelerate the discovery and design of new ferroelec. ABO₃-type perovskites. First, a classification model was constructed with data collected from publications to distinguish ferroelec. and nonferroelec. perovskites. The classification accuracies of LOOCV and the test set are 87.29% and 86.21%, resp. Then, two machine learning strategies, Machine-Learning Workflow and SISSO, were used to construct the regression models to predict the sp. surface area (SSA), band gap (E_g), Curie temperature (T_c), and dielec. loss (tan δ) of ABO₃-type perovskites. The correlation coefficients of LOOCV in the optimal models for SSA, E_g, and T_c are 0.935, 0.891, and 0.971, resp., while the correlation coefficient of the predicted and exptl. values of the SISSO model for tan δ prediction could reach 0.913. On the basis of the models, 20 ABO₃ ferroelec. perovskites with three different application prospects were screened out with the required properties, which could be explained by the patterns between the important descriptors and the properties by using SHAP. Furthermore, the constructed models were developed into web servers for the researchers to accelerate the rational design and discovery of ABO₃ ferroelec. perovskites with desired multiple properties. In the experiment, the researchers used many compounds, for example, 4-Oxo-tempo (cas: 2896-70-0Category: piperidines).

4-Oxo-tempo (cas: 2896-70-0) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

To mitigate self-discharge of lithium-sulfur batteries by optimizing ionic liquid electrolytes was written by Wang, Lina;Liu, Jingyuan;Yuan, Shouyi;Wang, Yonggang;Xia, Yongyao. And the article was included in Energy & Environmental Science in 2016.Electric Literature of C11H20F6N2O4S2 This article mentions the following:

Li-S batteries generally suffer from severe self-discharge when resting due to an internal polysulfide shuttle effect. Soluble long-chain polysulfide species (Li₂S_x, 4 ≤ x ≤ 8) would continue to dissolve and migrate to the neg. side to react with metallic Li. Here, we demonstrate pronounced suppression of polysulfide shuttle using an ionic liquid of the N-methyl-N-propylpiperidinium bis(trifluoromethanesulfonyl)imide (PP13TFSI)-based electrolyte. When working in combination with LiNO₃, zero self-discharge can be achieved to rest a full-charged Li-S cell for two days. The fascinating study clearly demonstrates that a promising practical Li-S battery with low self-discharge depends on both improvements on polysulfide diffusion control and Li-metal stabilization. In the experiment, the researchers used many compounds, for example, 1-Methyl-1-propylpiperidin-1-ium bis((trifluoromethyl)sulfonyl)amide (cas: 608140-12-1Electric Literature of C11H20F6N2O4S2).

1-Methyl-1-propylpiperidin-1-ium bis((trifluoromethyl)sulfonyl)amide (cas: 608140-12-1) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Electric Literature of C11H20F6N2O4S2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Synergism of the action of some stabilisers against the destruction of polymer materials was written by Zhukova, Irina;Flik, Evgeniya;Shubina, Elena;Mishurov, Vladimir;Kashparov, Ivan. And the article was included in E3S Web of Conferences in 2021.Category: piperidines This article mentions the following:

The process of thermal-oxidative degradation of polymer materials has been studied on the example of polyethylene in the presence of quinones and/or nitroxyl radicals. The synergistic effect of the pos. action of a mixture of stabilizers from a number of quinones and nitroxyl radicals on the destructive process of polyethylene has been established. It has been shown that the rate of degradation has significantly slowed down when an equimol. mixture of 4-acetylamino-2,2,6,6-tetramethylhexahydropyridine-1-oxyl and 2,6-di-tert-amyl-1,4-cyclohexadienone inhibitors has been introduced into the polymer. The kinetics of the initiated thermo-destructive process of polyethylene oxidation in the presence and absence of stabilizers has been studied. A mechanism of joint action of stabilizers based on their interaction with radicals and the breakage of radical chains, as well as a mechanism for the regeneration of stabilizers, has been proposed. In the experiment, the researchers used many compounds, for example, 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl (cas: 14691-89-5Category: piperidines).

4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl (cas: 14691-89-5) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Thioridazine reverts the phenotype in cellular and Drosophila models of amyotrophic lateral sclerosis by enhancing TDP-43 aggregate clearance was written by Cragnaz, Lucia;Spinelli, Greta;De Conti, Laura;Bureau, Emilie A.;Brownlees, Janet;Feiguin, Fabian;Romano, Valentina;Skoko, Natasa;Klima, Raffaella;Kettleborough, Catherine A.;Baralle, Francisco E.;Baralle, Marco. And the article was included in Neurobiology of Disease in 2021.Synthetic Route of C21H27ClN2S2 This article mentions the following:

Brain inclusions mainly composed of misfolded and aggregated TAR DNA binding protein 43 (TDP-43), are characteristic hallmarks of amyotrophic lateral sclerosis (ALS). Irresp. of the role played by the inclusions, their reduction represents an important therapeutic pathway that is worth exploring. Their removal can either lead to the recovery of TDP-43 function by removing the self-templating conformers that sequester the protein in the inclusions, and/or eliminate any potential intrinsic toxicity of the aggregates. The model demonstrated efficient aggregation of endogenous TDP-43, and concomitant loss of its splicing regulation function. We provided a proof-of-principle for its eventual use in high-throughput screening using compounds of the tricyclic family and showed that recovery of TDP-43 function can be achieved by the enhanced removal of TDP-43 aggregates by these compounds We observed that the degradation of the aggregates occurs independent of the autophagy pathway beyond autophagosome-lysosome fusion, but requires a functional proteasome pathway. The in vivo translational effect of the cellular model was tested with two of these compounds in a Drosophila model expressing a construct analogous to the cellular model, where thioridazine significantly improved the locomotive defect. This study also highlights the importance of a two-stage, in vitro and in vivo model system to cross-check the search for small mols. that can clear TDP-43 aggregates in TDP-43 proteinopathies. In the experiment, the researchers used many compounds, for example, Thioridazine hydrochloride (cas: 130-61-0Synthetic Route of C21H27ClN2S2).

Thioridazine hydrochloride (cas: 130-61-0) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Synthetic Route of C21H27ClN2S2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

TEMPO-mediated late stage photochemical hydroxylation of biaryl sulfonium salts was written by Zhao, Yue;Yu, Congjun;Liang, Wenjing;Atodiresei, Iuliana L.;Patureau, Frederic W.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2022.Recommanded Product: 4-Oxo-tempo This article mentions the following:

The late stage photochem. hydroxylation of biaryl sulfonium salts was enabled with a TEMPO derivative as a simple oxygen source, in metal free conditions. The scope and mechanism of this exceptionally simple synthetic method, which constructs important arylated phenols from aromatic C-H bonds, are herein discussed. In the experiment, the researchers used many compounds, for example, 4-Oxo-tempo (cas: 2896-70-0Recommanded Product: 4-Oxo-tempo).

4-Oxo-tempo (cas: 2896-70-0) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Recommanded Product: 4-Oxo-tempo

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Azaphosphatranes as hydrogen-bonding organocatalysts for the activation of carbonyl groups: investigation of lactide ring-opening polymerization was written by Zhang, Dawei;Jardel, Damien;Peruch, Frederic;Calin, Nathalie;Dufaud, Veronique;Dutasta, Jean-Pierre;Martinez, Alexandre;Bibal, Brigitte. And the article was included in European Journal of Organic Chemistry in 2016.Computed Properties of C10H21N This article mentions the following:

Azaphosphatranes [N(CH₂CH₂NR)₃PH]X (R = Me, ⁱPr, 4-CH₂C₆H₄OMe; X = NTf₂^–, BAr^F₄^–) were prepared as hydrogen-bond donors and organocatalysts for ring-opening polymerization of lactide. The hydrogen-bonding activation of C:O bonds by azaphosphatranes was explored in a model reaction, i.e., the ring-opening polymerization of lactide. The polymerization process was controlled, and allowed the preparation of polylactides with narrow dispersity under mild conditions (20 °C, 24 h, 10 mol-% catalyst loading). Interestingly, the steric hindrance of azaphosphatranes, as globular rigid structures, prevents any undesired interaction with the tertiary amine cocatalysts, as shown by x-ray anal. and semi-empirical calculations In contrast to their organocatalytic activity in the CO₂/epoxide reaction, all of the phosphonium derivatives tested were found to be efficient catalysts in this ROP benchmark reaction. In the experiment, the researchers used many compounds, for example, 1,2,2,6,6-Pentamethylpiperidine (cas: 79-55-0Computed Properties of C10H21N).

1,2,2,6,6-Pentamethylpiperidine (cas: 79-55-0) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Computed Properties of C10H21N

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Understanding of Molecular Substructures that Contribute to hERG K⁺ Channel Blockade: Synthesis and Biological Evaluation of E-4031 Analogues was written by Vilums, Maris;Overman, Jeroen;Klaasse, Elisabeth;Scheel, Olaf;Brussee, Johannes;Ijzerman, Adriaan P.. And the article was included in ChemMedChem in 2012.Synthetic Route of C12H16ClNO This article mentions the following:

Cardiotoxicity is a common side effect of a large variety of drugs that is often caused by off-target human ether-a-go-go-related gene (hERG) potassium channel blockade. In this study, we designed and synthesized a series of derivatives of the class III antiarrhythmic agent E-4031. These compounds where evaluated in a radioligand binding assay and automated patch clamp assay to establish structure-activity relationships (SAR) for their inhibition of the hERG K⁺ channel. Structural modifications of E-4031 were made by altering the peripheral aromatic moieties with a series of distinct substituents. Addnl., we synthesized several derivatives with a quaternary nitrogen and modified the center of the mol. by introduction of an addnl. nitrogen and deletion of the carbonyl oxygen. Some modifications caused a great increase in affinity for the hERG K⁺ channel, while other seemingly minor changes led to a strongly diminished affinity. Structures with quaternary amines carrying an addnl. aromatic moiety were found to be highly active in radioligand binding assay. A decrease in affinity was achieved by introducing an amide functionality in the central scaffold without directly interfering with the pK_a of the essential basic amine. The knowledge gained from this study could be used in early stages of drug discovery and drug development to avoid or circumvent hERG K⁺ channel blockade, thereby reducing the risk of cardiotoxicity, related arrhythmias and sudden death. In the experiment, the researchers used many compounds, for example, Phenyl(piperidin-4-yl)methanone hydrochloride (cas: 25519-80-6Synthetic Route of C12H16ClNO).

Phenyl(piperidin-4-yl)methanone hydrochloride (cas: 25519-80-6) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Synthetic Route of C12H16ClNO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Enantioseparation of paroxetine precursors by HPLC on amylose and tartardiamide-based chiral stationary phases was written by Bao, Zongbi;Su, Baogen;Yang, Yiwen;Ren, Qilong. And the article was included in Journal of Liquid Chromatography & Related Technologies in 2008.Category: piperidines This article mentions the following:

Two important precursors of antidepressant trans-(-)-paroxetine, i.e., trans-4-(4′-fluorophenyl)-3-hydroxymethyl-1-methylpiperidine and trans-3- ethoxycarbonyl-4-(4′-fluorophenyl)-1-methylpiperidine-2,6-dione were directly separated by HPLC on Chiralpak AD-H and Kromasil CHI-TBB columns. All the experiments were conducted in the normal phase mode. The mobile phases were mixtures of n-hexane and alc. modifiers including ethanol, 2-propanol, and 1-propanol, with or without addition of diethylamine. Excellent separation was obtained for both enantiomers. Effects and content of polar alc. modifiers on enantioseparation was studied. An unusual retention behavior was observed, i.e., the retention of enantiomers increased when the alc. modifier was changed from 2-propanol to ethanol. The elution orders of the enantiomers on both columns were examined The thermodn. parameters obtained from van’t Hoff plots were all neg., which indicated that the chiral separation were enthalpically driven. In the experiment, the researchers used many compounds, for example, ((3R,4S)-rel-4-(4-Fluorophenyl)-1-methylpiperidin-3-yl)methanol (cas: 109887-53-8Category: piperidines).

((3R,4S)-rel-4-(4-Fluorophenyl)-1-methylpiperidin-3-yl)methanol (cas: 109887-53-8) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem