Day: February 22, 2023

Triplet reactivity of spiroindolinooxazines studied by photosensitization was written by Favaro, Gianna;Malatesta, Vincenzo;Mazzucato, Ugo;Ottavi, Gaetano;Romani, Aldo. And the article was included in Molecular Crystals and Liquid Crystals Science and Technology in 1994.Safety of 1,3,3-Trimethyl-6′-(piperidin-1-yl)spiro[indoline-2,3′-naphtho[2,1-b][1,4]oxazine] This article mentions the following:

The quantum yields for the direct and triplet sensitized color-forming reactions of five spiroindolinooxazines were determined in methylcyclohexane. Higher triplet than singlet reactivities were generally found. In the experiment, the researchers used many compounds, for example, 1,3,3-Trimethyl-6′-(piperidin-1-yl)spiro[indoline-2,3′-naphtho[2,1-b][1,4]oxazine] (cas: 114747-45-4Safety of 1,3,3-Trimethyl-6′-(piperidin-1-yl)spiro[indoline-2,3′-naphtho[2,1-b][1,4]oxazine]).

1,3,3-Trimethyl-6′-(piperidin-1-yl)spiro[indoline-2,3′-naphtho[2,1-b][1,4]oxazine] (cas: 114747-45-4) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Safety of 1,3,3-Trimethyl-6′-(piperidin-1-yl)spiro[indoline-2,3′-naphtho[2,1-b][1,4]oxazine]

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Preparation and characterization of bifunctional reverse-mode polymer-dispersed liquid crystals was written by De Filpo, Giovanni;Formoso, Patrizia;Manfredi, Sabrina;Mashin, Alexander I.;Nicoletta, Fiore P.. And the article was included in Liquid Crystals in 2017.Formula: C27H29N3O This article mentions the following:

Reverse-mode polymer-dispersed liquid crystals (PDLCs) are transparent films in their OFF state (no applied elec. field) and become opaque in their ON state. The addition of a photo-chromic compound allows a color change of films, when they are UV-irradiated. The aim of this work was the preparation and characterization of bifunctional materials, able to change their transparency by application of an elec. field and color under UV irradiation In particular, the performance of reverse-mode PDLCs doped with different spiro(indolo)-oxazine mols. was investigated. Both the electro-optical and photo-chromic response of these systems were evaluated and compared. In the experiment, the researchers used many compounds, for example, 1,3,3-Trimethyl-6′-(piperidin-1-yl)spiro[indoline-2,3′-naphtho[2,1-b][1,4]oxazine] (cas: 114747-45-4Formula: C27H29N3O).

1,3,3-Trimethyl-6′-(piperidin-1-yl)spiro[indoline-2,3′-naphtho[2,1-b][1,4]oxazine] (cas: 114747-45-4) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Formula: C27H29N3O

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In Vivo Platelet Detection Using a Glycoprotein IIb/IIIa-Targeted Near-Infrared Fluorescence Imaging Probe was written by Ha, Khanh;Zheng, Xiaoxin;Kessinger, Chase W.;Mauskapf, Adam;Li, Wenzhu;Kawamura, Yoichiro;Orii, Makoto;Hilderbrand, Scott A.;Jaffer, Farouc A.;McCarthy, Jason R.. And the article was included in ACS Sensors in 2021.SDS of cas: 142355-83-7 This article mentions the following:

Platelets play a prominent role in multiple diseases, in particular arterial and venous thrombosis and also in atherosclerosis and cancer. To advance the in vivo study of the biol. activity of this cell type from a basic exptl. focus to a clin. focus, new translatable platelet-specific mol. imaging agents are required. Herein, the development of a near-IR fluorescence probe based upon tirofiban, a clin. approved small-mol. glycoprotein IIb/IIIa inhibitor (GPIIb/IIIa) was reported. Through in vitro experiments with human platelets and in vivo ones in a murine model of deep-vein thrombosis, we demonstrate the avidity of the generated probe for activated platelets, with the added benefit of a short blood half-life, thereby enabling rapid in vivo visualization within the vasculature. In the experiment, the researchers used many compounds, for example, 4-(1-Boc-4-piperidyl)-1-butanol (cas: 142355-83-7SDS of cas: 142355-83-7).

4-(1-Boc-4-piperidyl)-1-butanol (cas: 142355-83-7) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.SDS of cas: 142355-83-7

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Synthesis and pharmacological evaluation of some 6-substituted 7-methyl-1,4-dioxa-7-azaspiro[4.5]decanes as potential dopamine agonists was written by Brubaker, Abram N.;Colley, Matt Jr.. And the article was included in Journal of Medicinal Chemistry in 1986.Related Products of 50606-58-1 This article mentions the following:

Title spiro compounds I (R = Ph, 3- or 4-indolyl) were synthesized via alkylation of enamine II. The spirodecane derivatives were evaluated for in vivo central and peripheral dopamine agonist activity. None of the compounds displayed central nervous system activity; however, the 4-indolylmethyl analog exhibited potent dopamine agonist activity in the cat cardioaccelerator nerve assay and possesses an ID₅₀ of 0.095 μmol/kg compared to apomorphine, which possesses and ID₅₀ of 0.0348 μmol/kg in the same assay. In the experiment, the researchers used many compounds, for example, 1-Benzylpiperidin-3-one hydrochloride (cas: 50606-58-1Related Products of 50606-58-1).

1-Benzylpiperidin-3-one hydrochloride (cas: 50606-58-1) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising α-glucosidase inhibitors. The former are analogs of DNJ with an improved α-glucosidase inhibitory profile than that of DNJ. Boisson et al.Related Products of 50606-58-1

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Synthesis of 3,5-dichloro-2-pentanone was written by Chen, Ming-ming;Liu, Wei;Chen, Meng-ci;Zeng, Xue-yun;Chen, Ming. And the article was included in Jingxi Huagong Zhongjianti in 2015.SDS of cas: 50533-97-6 This article mentions the following:

The synthesis of 3,5-dichloro-2-pentanone was achieved with α-acetyl-α-chloride-γ-butyrolactone and triphosgene as raw materials and N,N-dimethyl-piperidine hydro-chloride as the catalyst. The main influence factors including temperature, the dropping time of triphosgene, the ratio of materials, the types of catalysts, the blowing rate of nitrogen and other factors were evaluated. Under the best conditions of reaction, the purity of 3,5-dichloro-2-pentanone reached 94.0%, and the yield was up to 81.5% based on the starting material of α-acetyl-α-chloride-γ-butyrolactone. In the experiment, the researchers used many compounds, for example, N,N-Dimethylpiperidin-4-amine (cas: 50533-97-6SDS of cas: 50533-97-6).

N,N-Dimethylpiperidin-4-amine (cas: 50533-97-6) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.SDS of cas: 50533-97-6

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

New basic esters of 3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic acid endowed with spasmolytic properties: synthesis and pharmacological-pharmacokinetic evaluation was written by Nardi, D.;Leonardi, A.;Pennini, R.;Tajana, A.;Cazzulani, P.;Testa, R.. And the article was included in Arzneimittel-Forschung in 1993.Application In Synthesis of 1-(3-Chloropropyl)piperidine hydrochloride This article mentions the following:

Basic esters of 3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic acid (I) were prepared as flavoxate analogs. The activity of I esters as spasmolytics was tested and compared to flavoxate. Terflavoxate hydrochloride (II) showed affinity for muscarinic receptors but was devoid of functional antimuscarinic properties. In the experiment, the researchers used many compounds, for example, 1-(3-Chloropropyl)piperidine hydrochloride (cas: 5472-49-1Application In Synthesis of 1-(3-Chloropropyl)piperidine hydrochloride).

1-(3-Chloropropyl)piperidine hydrochloride (cas: 5472-49-1) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Application In Synthesis of 1-(3-Chloropropyl)piperidine hydrochloride

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Discovery of Potent PROTACs Targeting EGFR Mutants through the Optimization of Covalent EGFR Ligands was written by Zhao, Hong-Yi;Wang, Hai-Peng;Mao, Yu-Ze;Zhang, Hao;Xin, Minhang;Xi, Xiao-Xiao;Lei, Hao;Mao, Shuai;Li, Dong-Hui;Zhang, San-Qi. And the article was included in Journal of Medicinal Chemistry in 2022.Related Products of 216854-23-8 This article mentions the following:

To overcome the intractable problem of drug resistance, proteolysis targeting chimeras (PROTACs) targeting EGFR mutants were developed by optimizing covalent EGFR ligands. Covalent or reversible covalent pyrimidine- or purine-containing PROTACs were designed, synthesized, and evaluated. As a consequence, covalent PROTAC I, with a novel purine-containing EGFR ligand, was discovered as a highly potent degrader against EGFR^L858R/T790M and EGFR^del19, reaching the lowest DC₅₀ values among all reported EGFR-targeting PROTACs. Furthermore, I exhibited excellent cellular activity against the H1975 and HCC827 cell lines with high selectivity. Mechanism investigation indicated that the lysosome was involved in the degradation process. Importantly, the covalent binding strategy was proven to be an effective approach for the design of PROTACs targeting EGFR^L858R/T790M, which laid the practical foundation for further development of potent EGFR-targeting PROTACs. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl piperidin-3-ylcarbamate (cas: 216854-23-8Related Products of 216854-23-8).

(S)-tert-Butyl piperidin-3-ylcarbamate (cas: 216854-23-8) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Related Products of 216854-23-8

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Porous protoporphyrin IX-embedded cellulose diacetate electrospun microfibers in antimicrobial photodynamic inactivation was written by Wang, Tingting;Ke, Huizhen;Chen, Shiping;Wang, Jian;Yang, Wushi;Cao, Xiuming;Liu, Jingyan;Wei, Qufu;Ghiladi, Reza A.;Wang, Qingqing. And the article was included in Materials Science & Engineering, C: Materials for Biological Applications in 2021.Electric Literature of C9H16NO2 This article mentions the following:

Motivated by the need for self-disinfecting materials that can be used to reduce the surface transmission of harmful microbes to healthy hosts, here we prepared a photodynamic antimicrobial membrane comprised of electrospun cellulose diacetate (CA) microfibers into which the photosensitizer protoporphyrin IX (PpIX) was in situ embedded. The resultant porous PpIX-embedded CA (PpIX/CA) microfibrous membranes were prepared with two different photosensitizer loadings: 5 and 10 wt% PpIX with respect to CA (85 and 170 nmol PpIX/mg membrane, resp.). The singlet oxygen (¹O₂) generated by the embedded photosensitizer was confirmed by ESR spectroscopic studies through generation of the TEMPO radical, and its photooxidation efficiency was further investigated using potassium iodide as a model substrate. Antibacterial photodynamic inactivation studies showed that the PpIX/CA membrane achieved a 99.8% reduction in Gram-pos. S. aureus after illumination (Xe lamp, 65 ± 5 mW/cm², λ ≥ 420 nm; 30 min), with a lower level of reduction (86.6%) for Gram-neg. E. coli. Potentiation with potassium iodide was found to be an effective way to further enhance the antimicrobial efficacy of the PpIX/CA microfibrous membrane, achieving 99.9999% (6 log units) inactivation of both S. aureus and E. coli in the presence of 25 and 100 mM KI, resp. These findings indicate that the electrospun CA microfibrous membrane is an ideal matrix for a photosensitizer such as PpIX to be embedded and effectively sensitized upon visible light illumination, and its antimicrobial photodynamic inactivation efficiency could be strongly enhanced with the increased KI addition, showing a promising future for its use in pathogen transmission defensive materials. In the experiment, the researchers used many compounds, for example, 4-Oxo-tempo (cas: 2896-70-0Electric Literature of C9H16NO2).

4-Oxo-tempo (cas: 2896-70-0) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Electric Literature of C9H16NO2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Scratch and recovery characteristics of automotive clearcoats containing blocked polyisocyanate crosslinkers was written by Noh, Seung Man;Nam, Joon Hyun;Oh, Jung Kwon;Jung, Hyun Wook. And the article was included in Journal of Coatings Technology and Research in 2015.Computed Properties of C30H56N2O4 This article mentions the following:

Scratch characteristics and self-recovery behaviors of automotive clearcoats including newly designed silane-modified blocked polyisocyanate (SMBI) as an organic-inorganic hybrid crosslinker were compared with those with the com. well-known crosslinkers such as blocked HDI-based and blocked IPDI-based polyisocyanates. To extensively scrutinize the effects of various crosslinkers with different chem. structures on the chem. and mech. properties of clearcoats themselves, rigid-body pendulum tester anal., creep-recovery anal., and FTIR anal. were performed, resulting in a noticeable variation in curing features and crosslinking networks. Employing the overall coating systems by depositing clearcoats with different crosslinkers above the same undercoats on galvanized steel, the scratch behaviors on the surface of the outermost clearcoat layer were examined via the nano-scratch tester for scratch depth profiles and at. force microscopy for three-dimensional scratch images, under various self-reflow temperatures and duration time periods. The results demonstrated that the SMBI crosslinker induced a considerably higher degree of crosslinked networks, through the reaction of urethane bonds and silanol bonds in clearcoats, in comparison with the blocked HDI and IPDI polyisocyanates. Also, the recoverable behaviors of scratched clearcoats containing different blocked polyisocyanates were affected by the intrinsic chem. structures of crosslinkers, as well as scratch-recovery conditions such as external temperature and duration times. In the experiment, the researchers used many compounds, for example, Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate (cas: 41556-26-7Computed Properties of C30H56N2O4).

Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate (cas: 41556-26-7) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising α-glucosidase inhibitors. The former are analogs of DNJ with an improved α-glucosidase inhibitory profile than that of DNJ. Boisson et al.Computed Properties of C30H56N2O4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Optical evodiamine derivatives: Asymmetric synthesis and antitumor activity was written by Li, Zhen-Gang;Dong, Guo-Qiang;Wang, Sheng-Zheng;Miao, Zhen-Yuan;Yao, Jian-Zhong;Zhang, Wan-Nian;Sheng, Chun-Quan. And the article was included in Chinese Chemical Letters in 2015.Application In Synthesis of 2-Oxopiperidine-3-carboxylic acid This article mentions the following:

Evodiamine and its derivatives have an asym. center at the C13b position. Herein, isomers of evodiamine derivatives were obtained by straightforward asym. total synthesis. Their inhibitory activities toward topoisomerases I and II and their cytotoxicities in cancer cell lines were evaluated. All the four isomers exhibited good to excellent antitumor potency and the (S)-isomers were generally more active than the (R)-isomers. The binding modes of compound I with topoisomerases I and II were also clarified by mol. docking. In the experiment, the researchers used many compounds, for example, 2-Oxopiperidine-3-carboxylic acid (cas: 41888-21-5Application In Synthesis of 2-Oxopiperidine-3-carboxylic acid).

2-Oxopiperidine-3-carboxylic acid (cas: 41888-21-5) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising α-glucosidase inhibitors. The former are analogs of DNJ with an improved α-glucosidase inhibitory profile than that of DNJ. Boisson et al.Application In Synthesis of 2-Oxopiperidine-3-carboxylic acid

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem