Day: February 22, 2023

Synthesis of piperidinemethanols. I. Synthesis of α,α-diphenyl- or α-phenyl-α-thienyl-l-methylpiperidine-methanol was written by Sugimoto, Norio;Kugita, Hiroshi. And the article was included in Yakugaku Zasshi in 1953.Application of 30727-18-5 This article mentions the following:

A 2-BzC₅H₄N (13.5 g.), 14 g. MeI, and 35 ml. MeOH heated 3 hrs. at 100° in a sealed tube and the MeOH removed give sirupy 2-BzC₅H₄N.MeI; this with AgCl gives 16 g. sirupy 2-BzC₅H₄N. MeCl; catalytic reduction of this with 0.3 g. PtO₂ in 70 ml. alc., addition of a small amount of water, making alk. with K₂CO₃, extraction with Et₂O, and distillation, gives 11 g. liquid, b₁₀ 153-62°, the liquid, in a small amount of Me₂CO, treated with 13.5 g. picric acid, and the picrate fractionally crystallized from MeOH and decomposed with 25% NH₄OH gives 2.1 g. 2-PhCH(OH)C₅H₉NMe (IA), b_5.5 140-3°, plates, m. 61-2° (picrate, m. 201-4°); 3.8 g. isomer (IB) of IA, b_6.6 143-6° (picrate, m. 158-63°); 0.3 g. m. 140° (picrate, m. 170-2°); and 2.3 g. (IC), b_5.5 138-45° (picrate, sirupy; picrolonate, m. 160-3°). IB (3.8 g.) and 60 ml. AcOH at 50-60°treated dropwise with 1.3 g. CrO₃ in 11 ml. 90% AcOH, heated 30 min. at 80°, part of AcOH removed in vacuo, the residue neutralized with NaOH, the oily layer extracted with Et₂O, and the extract distilled give 80% 2-BzC₅H₉NMe (II), b_5.5 136-9° (picrolonate, rhombic, m. 160-3°); similarly, IA gives II, b_4.5 135° (picrolonate, m. 160-3°). IA (1 g.) distilled in vacuo, and the fraction b_3.5 128.5-9.5° treated with picric acid gives 1.9 g. picrate, m. 206-7°; the mother liquor treated with NH₄OH, and extracted with Et₂O, yields a picrolonate of II, m. 160-2°. On catalytic reduction IC absorbed 1 mole H and gave a picrate, m. 204-6° (which lowers the m.p. of IA picrate). On catalytic reduction in 100 ml. EtOH with 0.5 g. PtO₂ 32.6 g. sirupy 3-PhCH(OH)C₅H₄N.MeCl absorbed 10 1. H (3 moles); removing the EtOH, neutralizing with K₂CO₃, extracting with Et₂O, and distilling gave 3-PhCH(OH)C₅H₉NMe (IIIA), columns, m. 125-7°, an isomer (IIIB) of IIIA, rhombic, m. 116-17° (yield of IIIA and IIIB combined 10.5 g.), 5.5 g. 3-BzC₅H₉NMe (IV) (picrate, m. 193-5°), and 7.1 g. liquid (picrate, m. 154.5-5°). A mixture (4 g.) of IIIA and IIIB in 80 ml. AcOH at 50° treated dropwise with 1.3 g. CrO₃ in 6 ml. 80% AcOH, heated 1 hr. at 90°, and the product treated as for II gives 3.5 g. (87.5%) IV, b₂ 140-4°; picrate 194-6° (from dioxane). 4-BzC₅H₄N (9.1 g.), 14.2 g. MeI, and 50 ml. MeOH, heated 2 hrs. on a water bath, the MeOH removed, and the residue washed with Me₂CO and recrystallized from alc. give 13 g. 4-BzC₅H₄N.MeI (V), m. 80-180°, which on catalytic reduction in 80 ml. MeOH with 0.3 g. PtO₂ absorbed 4 moles H and gave 8 g. 4-PhCH(OH)C₆H₉NMe (VI). m. 157-9° (from dilute alc.); 3 g. VI and 1 g. CrO₃ in AcOH, heated 20 min. at 90°, gave 2.1 g. (70%) 4-BzC₅H₉NMe (VII), b₅ 157-9°; picrate, m. 200.5-2°. II (1.35 g.) in 10 ml. dry Et₂O added to PhMgBr (2.3 g. PhBr, 0.35 g. Mg, and 10 ml. Et₂O), the mixture refluxed 45 min., decomposed with NH₄Cl, and the product extracted with Et₂O, taken up in 10% HCl, neutralized with K₂CO₃, extracted with Et₂O, and distilled gave 0.6 g. 2-RC₅H₉NMe [VIII, R = Ph₂C(OH) (IX)], columns, m. 88.5-9.5°; similarly, IV yielded 72.3% 3-RC₅H₉NMe (X, R = IX) needles, m. 147-8° (from dilute alc.); VII yielded 46.4% 4-RC₅H₉NMe (XI, R = IX), granules, m. 134-6° (from petr. ether). 2-(Ph₂CH(OH)C₅H₄N.MeCl, decompose 227°, (6 g.) on catalytic reduction in 100 ml. alc. with 0.2 g. PtO₂ for 3 hrs. absorbed 3 moles H; the product filtered, the alc. in the filtrate removed, and the residue taken up with water, made alk. with K₂CO₃, and extracted with Et₂O gave 5.3 g. VIII, m. 89-90° (from petr. ether). II (2.5 g.) in 30 ml. dry Et₂O added a Grignard reagent from 3 g. 2-bromothiophene, 0.45 g. Mg, and 30 ml. Et₂O, the mixture refluxed 3 hrs., and decomposed with aqueous NH₄Cl, gave 1.6 g. 2-PhCR(OH)C₅H₉NMe (XII, R = 2-thienyl), needles, m. 93-4° (from dilute alc.); similarly are obtained 67.5% 3-PhCR(OH)C₅H₉NMe, needles, m. 142-3°, and 15.4% 4-PhCR(OH)C₅H₉NMe, prisms, m. 147-8° (from petr. ether). In the experiment, the researchers used many compounds, for example, Ethyl 1-methylpipecolinate (cas: 30727-18-5Application of 30727-18-5).

Ethyl 1-methylpipecolinate (cas: 30727-18-5) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Application of 30727-18-5

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Chemo-Enzymatic Oxidative Rearrangement of Tertiary Allylic Alcohols: Synthetic Application and Integration into a Cascade Process was written by Brenna, Elisabetta;Crotti, Michele;De Pieri, Matteo;Gatti, Francesco G.;Manenti, Gabriele;Monti, Daniela. And the article was included in Advanced Synthesis & Catalysis in 2018.Recommanded Product: 219543-09-6 This article mentions the following:

A chemo-enzymic catalytic system, comprised of Bobbitt’s salt and laccase from Trametes versicolor, allowed the [1,3]-oxidative rearrangement of endocyclic allylic tertiary alcs. into the corresponding enones under an Oxygen atm. in aqueous media. The yields were in most cases quant., especially for the cyclopent-2-en-1-ol or the cyclohex-2-en-1-ol substrates without an electron withdrawing group (EWG) on the side chain. Transpositions of macrocyclic alkenols or tertiary alcs. bearing an EWG on the side chain were instead carried out in acetonitrile by using an immobilized laccase preparation Dehydro-Jasmone, dehydro-Hedione, dehydro-Muscone and other fragrance precursors were directly prepared with this procedure, while a synthetic route was developed to easily transform a cyclopentenone derivative into trans-Magnolione and dehydro-Magnolione_. The rearrangement of exocyclic allylic alcs. was tested as well, and a dynamic kinetic resolution was observed: α,β-unsaturated ketones with (E)-configuration and a high diastereomeric excess were synthesized. Finally, the 2,2,6,6-tetramethyl-1-piperidinium tetrafluoroborate (TEMPO⁺BF₄^–)/laccase catalyzed oxidative rearrangement was combined with the ene-reductase/alc. dehydrogenase cascade process in a one-pot three-step synthesis of cis or trans 3-methylcyclohexan-1-ol, in both cases with a high optical purity. In the experiment, the researchers used many compounds, for example, 4-Acetamido-2,2,6,6-tetramethyl-1-oxopiperidinium Tetrafluoroborate (cas: 219543-09-6Recommanded Product: 219543-09-6).

4-Acetamido-2,2,6,6-tetramethyl-1-oxopiperidinium Tetrafluoroborate (cas: 219543-09-6) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Recommanded Product: 219543-09-6

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

High throughput measurement of Ca⁺⁺ dynamics in human stem cell-derived cardiomyocytes by kinetic image cytometry: a cardiac risk assessment characterization using a large panel of cardioactive and inactive compounds was written by Lu, Hua Rong;Whittaker, Ross;Price, Jeffrey H.;Vega, Raquel;Pfeiffer, Emily R.;Cerignoli, Fabio;Towart, Rob;Gallacher, David J.. And the article was included in Toxicological Sciences in 2015.Reference of 119431-25-3 This article mentions the following:

Human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) are emerging as a powerful in vitro model for cardiac safety assessment which may allow for better identification of compounds with poor arrhythmogenic liability profiles early in the drug discovery process. Here, we describe our examination of the Kinetic Image Cytometer (KIC) system’s ability to predict adverse compound effects using hiPS-CMs and a library of 53 compounds, the majority of which are known to be cardioactive compounds, and several neg. controls. The KIC provides a high throughput method for analyzing intracellular calcium transients. In the cardiomyocyte, intracellular calcium transients integrate the electrochem. signals of the action potential (AP) with the mol. signaling pathways regulating contraction. Drug-induced alterations in the shape and duration of AP result in changes to the shape and duration of the intracellular calcium transient. By examining calcium transient dynamics in hiPS-CMs, KIC can be used as a phenotypic screen to assess compound effects across multiple ion channel types (MITs), detecting MITs, calcium handling and signaling effects. The results of this blinded study indicate that using hiPS-CMs, KIC is able to accurately detect drug-induced changes in Ca²⁺ transient dynamics (ie, duration and beat rate) and therefore, may be useful in predicting drug-induced arrhythmogenic liabilities in early de-risking within the drug discovery phase. In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol (cas: 119431-25-3Reference of 119431-25-3).

1-(4-Chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol (cas: 119431-25-3) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising α-glucosidase inhibitors. The former are analogs of DNJ with an improved α-glucosidase inhibitory profile than that of DNJ. Boisson et al.Reference of 119431-25-3

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

The multi-targeting ligand ST-2223 with histamine H₃ receptor and dopamine D₂/D₃ receptor antagonist properties mitigates autism-like repetitive behaviors and brain oxidative stress in mice was written by Eissa, Nermin;Venkatachalam, Karthikkumar;Jayaprakash, Petrilla;Falkenstein, Markus;Dubiel, Mariam;Frank, Annika;Reiner-Link, David;Stark, Holger;Sadek, Bassem. And the article was included in International Journal of Molecular Sciences in 2021.Safety of 1-(3-Chloropropyl)piperidine hydrochloride This article mentions the following:

Autism spectrum disorder (ASD) is a complex heterogeneous neurodevelopmental disorder characterized by social and communicative impairments, as well as repetitive and restricted behaviors (RRBs). With the limited effectiveness of current pharmacotherapies in treating repetitive behaviors, the present study determined the effects of acute systemic treatment of the novel multi-targeting ligand ST-2223, with incorporated histamine H₃ receptor (H₃R) and dopamine D₂/D₃ receptor affinity properties, on ASD-related RRBs in a male Black and Tan BRachyury (BTBR) mouse model of ASD. ST-2223 (2.5, 5, and 10 mg/kg, i.p.) significantly mitigated the increase in marble burying and self-grooming, and improved reduced spontaneous alternation in BTBR mice (all p < 0.05). Similarly, reference drugs memantine (MEM, 5 mg/kg, i.p.) and aripiprazole (ARP, 1 mg/kg, i.p.), reversed abnormally high levels of several RRBs in BTBR (p < 0.05). Moreover, ST-2223 palliated the disturbed anxiety levels observed in an open field test (all p < 0.05), but did not restore the hyperactivity parameters, whereas MEM failed to restore mouse anxiety and hyperactivity. In addition, ST-2223 (5 mg/kg, i.p.) mitigated oxidative stress status by decreasing the elevated levels of malondialdehyde (MDA), and increasing the levels of decreased glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) in different brain parts of treated BTBR mice (all p < 0.05). These preliminary in vivo findings demonstrate the ameliorative effects of ST-2223 on RRBs in a mouse model of ASD, suggesting its pharmacol. prospective to rescue core ASD-related behaviors. Further confirmatory investigations on its effects on various brain neurotransmitters, e.g., dopamine and histamine, in different brain regions are still warranted to corroborate and expand these initial data. In the experiment, the researchers used many compounds, for example, 1-(3-Chloropropyl)piperidine hydrochloride (cas: 5472-49-1Safety of 1-(3-Chloropropyl)piperidine hydrochloride).

1-(3-Chloropropyl)piperidine hydrochloride (cas: 5472-49-1) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Safety of 1-(3-Chloropropyl)piperidine hydrochloride

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Design and preparation of controlled floating gastroretentive delivery systems for enhanced fexofenadine hydrochloride oral bioavailability was written by Saab, May;Samy, Wael;Issa, Mohamed;El-Maradny, Hoda. And the article was included in Tropical Journal of Pharmaceutical Research in 2018.Computed Properties of C32H40ClNO4 This article mentions the following:

To design and prepare effervescent floating gastroretentive tablets for controlled fexofenadine hydrochloride (HCl) release and enhanced oral bioavailability. Various tablet formulations of the drug were prepared by direct compression. A systematic approach in the design of the formulations was adopted, where, first, formulations consisting of single polymers with a high polymer : sodium bicarbonate ratio were investigated for its physicochem. properties (in-vitro floating behavior, drug release profile, etc). Next, improvement of tablets′ properties was achieved by decreasing polymer : sodium bicarbonate ratio. The formulations were evaluated in vitro and in vivo in albino rabbits Results: The formulation consisting of hydroxypropyl methylcellulose K15M/hydroxypropyl methylcellulose K100LV at 1 : 2 ratio (F8) showed good floating properties (14 s floating lag time) with nearly zero order controlled drug release for 24 h (R2= 0.9876). In-vivo bioavailability studies of F8 in albino rabbits showed a significant increase in area under the curve (AUC, 134 %, p < 0.05) and hence an improvement in its oral bioavailability, compared to a com. conventional product. The good quality of the effervescent floating gastroretentive tablets of fexofenadine HCl develoral bioavailabilityoped is an indication that the approach used is suitable for the formulation of the drug for controlled drug release and enhanced oral bioavailabiliy. In the experiment, the researchers used many compounds, for example, 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride (cas: 153439-40-8Computed Properties of C32H40ClNO4).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride (cas: 153439-40-8) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Computed Properties of C32H40ClNO4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Ethidium bromide exposure unmasks an antibiotic efflux system in Rhodococcus equi was written by Rampacci, Elisa;Marenzoni, Maria Luisa;Cannalire, Rolando;Pietrella, Donatella;Sabatini, Stefano;Giovagnoli, Stefano;Felicetti, Tommaso;Pepe, Marco;Passamonti, Fabrizio. And the article was included in Journal of Antimicrobial Chemotherapy in 2021.Application In Synthesis of 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine This article mentions the following:

This study introduces a newly created strain (Rhodococcus equiEtBr25) by exposing R. equi ATCC 33701 to ethidium bromide (EtBr), a substrate for MDR transporters. Such an approach allowed us to investigate the resulting phenotype and genetic mechanisms underlying the efflux-mediated resistance in R. equi. R. equi ATCC 33701 was stimulated with increasing concentrations of EtBr. The antimicrobial susceptibility of the parental strain and R. equiEtBr25 was investigated in the presence/absence of efflux pump inhibitors (EPIs). EtBr efflux was evaluated by EtBr-agar method and flow cytometry. The presence of efflux pump genes was determined by conventional PCR before to quantify the expression of 30 genes coding for membrane transporters by qPCR. The presence of erm(46) and mutations in 23S rRNA, and gyrA/gyrB was assessed by PCR and DNA sequencing to exclude the occurrence of resistance mechanisms other than efflux. R. equiEtBr25 showed an increased EtBr efflux. Against this strain, the activity of EtBr, azithromycin and ciprofloxacin was more affected than that of rifampicin and azithromycin/rifampicin combinations. Resistances were reversed by combining the antimicrobials with EPIs. Gene expression anal. detected a marked up-regulation of REQ_RS13460 encoding for a Major Facilitator Superfamily (MFS) transporter. G→A transition occurred in the transcriptional repressor tetR/acrR adjacent to REQ_RS13460. Exposure of R. equi to EtBr unmasked an efflux-mediated defense against azithromycin and ciprofloxacin, which seemingly correlates with the overexpression of a specific MFS transporter. This genotype may mirror an insidious low-level resistance of clin. important isolates that could be countered by EPI-based therapies. In the experiment, the researchers used many compounds, for example, 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine (cas: 50-52-2Application In Synthesis of 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine).

10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine (cas: 50-52-2) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Application In Synthesis of 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Influence of NH₃ and NH₄⁺ on anaerobic digestion and microbial population structure at increasing total ammonia nitrogen concentrations was written by Mlinar, Stanislava;Weig, Alfons R.;Freitag, Ruth. And the article was included in Bioresource Technology in 2022.Quality Control of 4-Oxo-tempo This article mentions the following:

Despite the extensive research dedicated to ammonia inhibition, the effect of NH₃ and NH₄⁺ on each anaerobic digestion stage and the associated microorganisms is still not completely understood. In the past, the focus was mainly on methanogenesis and either on NH₃ or total ammonia nitrogen (TAN). Here, anaerobic digestion of two defined substrates, namely starch/NH₄Cl and casein, was investigated particularly regarding the effects of different NH₃/NH₄⁺ ratios on the involved microorganisms. TAN affected bacteria, primarily gram-pos. ones, whereas archaea responded largely to the NH₃ concentration These sensitivity differences are attributed to differences in the corresponding cell-membrane structures. A TAN decrease via stripping performed in two full-scale agricultural biogas plants resulted in increased bacterial diversity, with a pronounced increase in the propionate acetogens′ abundance. Based on these data, it is suggested that inhibition can be avoided and processes stabilized in biogas plants by adjusting the NH₃/NH₄⁺ ratio, when feeding nitrogen-rich substrates. In the experiment, the researchers used many compounds, for example, 4-Oxo-tempo (cas: 2896-70-0Quality Control of 4-Oxo-tempo).

4-Oxo-tempo (cas: 2896-70-0) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Quality Control of 4-Oxo-tempo

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Water-Soluble Progesterone Analogues Are Effective, Injectable Treatments in Animal Models of Traumatic Brain Injury was written by Guthrie, David B.;Stein, Donald G.;Liotta, Dennis C.;Lockwood, Mark A.;Sayeed, Iqbal;Atif, Fahim;Arrendale, Richard F.;Reddy, G. Prabhakar;Evers, Taylor J.;Marengo, Jose R.;Howard, Randy B.;Culver, Deborah G.;Natchus, Michael G.. And the article was included in ACS Medicinal Chemistry Letters in 2012.Electric Literature of C11H19NO4 This article mentions the following:

After more than 30 years of research and 30 failed clin. trials with as many different treatments, progesterone is the first agent to demonstrate robust clin. efficacy as a treatment for traumatic brain injuries. It is currently being investigated in two, independent phase III clin. trials in hospital settings; however, it presents a formidable solubility challenge that has so far prevented the identification of a formulation that would be suitable for emergency field response use or battlefield situations. Accordingly, we have designed and tested a novel series of water-soluble analogs that address this critical need. We report here the synthesis of C-20 oxime conjugates of progesterone as therapeutic agents for traumatic brain injuries with comparable efficacy in animal models of traumatic brain injury and improved solubility and pharmacokinetic profiles. Pharmacodynamic anal. reveals that a nonprogesterone steroidal analog may be primarily responsible for the observed activity. In the experiment, the researchers used many compounds, for example, (R)-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid (cas: 163438-09-3Electric Literature of C11H19NO4).

(R)-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid (cas: 163438-09-3) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Electric Literature of C11H19NO4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Neuroprotective effects of 7-nitroindazole in the gerbil model of global cerebral ischemia was written by O’Neill, Michael J.;Hicks, Caroline;Ward, Mark. And the article was included in European Journal of Pharmacology in 1996.SDS of cas: 119431-25-3 This article mentions the following:

To evaluate the role played by nitric oxide in global cerebral ischemia we examined the effects of 7-nitroindazole and a sodium salt of 7-nitroindazole (inhibitors of neuronal nitric oxide (NO) synthase) and N^G-nitro-L-arginine Me ester (a more general inhibitor of NO synthase) in the gerbil model of cerebral ischemia. Four experiments were carried out. In the first experiment, animals were either sham -operated, subjected to 5 min bilateral carotid occlusion (BCAO) or administered 7-nitroindazole or N^G-nitro-L-arginine Me ester immediately after occlusion followed by three further doses at 3, 6 and 24 h post-occlusion. In the second experiment, we examined the effects of a sodium salt of 7-nitroindazole, which is more soluble than 7-nitroindazole, using the same protocol. In the third experiment, the effects of the sodium salt of 7-nitroindazole administered at 10 mg/kg at 0, 3, 6, 24, 27, 30, 33, 52, 55, 72, 75 and 78 h post-occlusion or at 0.05 mg/h for 72 h via mini-pumps were evaluated. In sep. experiments, we examined the effects of three reference compounds dizocilpine (MK-801), 2,3-dihydroxy-6-nitro-7-sulfamoylbenz(F)quinoxaline (NBQX) and eliprodil using the same model. Extensive neuronal death was observed in the CA1 layer of the hippocampus in 5 min bilateral carotid occluded animals 5 days after surgery. Both 7-nitroindazole and N^G-nitro-L-arginine Me ester provided significant neuroprotection against this neuronal death. The sodium salt of 7-nitroindazole showed no protection when administered up to 12 times post-occlusion, but did provide significant neuroprotection when administered via mini-pump. The neuroprotection was similar to that provided by MK-801 and eliprodil, but not as good as that observed with NBQX. These results indicate that nitric oxide plays a role in ischemic cell death and that selective neuronal nitric oxide synthase inhibitors can protect against ischemic brain damage. In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol (cas: 119431-25-3SDS of cas: 119431-25-3).

1-(4-Chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol (cas: 119431-25-3) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising α-glucosidase inhibitors. The former are analogs of DNJ with an improved α-glucosidase inhibitory profile than that of DNJ. Boisson et al.SDS of cas: 119431-25-3

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Development of optical transparent pressure sensitive adhesive film was written by Wei, Hongli;Li, Huilu;Shao, Kangchen;Han, Jiangling. And the article was included in Xiandai Suliao Jiagong Yingyong in 2014.Recommanded Product: 41556-26-7 This article mentions the following:

With EB524 and EP828 as matrix resin, acrylic resin glue as tackifying resin and adding Tinuvin765 hindered amine light stabilizer, an optical transparency (OCA) pressure sensitive adhesive film with good light transmittance and bonding strength was prepared The influences of matrix resin, tackifying resin and light stabilizer on the properties of pressure sensitive adhesive film were discussed by testing the film-forming, holding stick properties, light transmittance, refractive index and resistance to aging. The results showed that the OCA pressure sensitive adhesive film had better film-forming property and aging resistance, the holding stick properties were excellent. Its light transmission rate reached 90.24%, refractive index reached 1.514 when the mass ratio of EB524 and EP828 was 1:5, the mass fractions of tackifying resin and Tinuvin765 were 5% and 0.5%, resp. In the experiment, the researchers used many compounds, for example, Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate (cas: 41556-26-7Recommanded Product: 41556-26-7).

Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate (cas: 41556-26-7) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Recommanded Product: 41556-26-7

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem