Day: February 22, 2023

CuI/N4 ligand/TEMPO derivatives: a mild and highly efficient system for aerobic oxidation of primary alcohols was written by Zhang, Shufang;Miao, Chengxia;Xu, Daqian;Sun, Wei;Xia, Chungu. And the article was included in Cuihua Xuebao in 2014.Quality Control of 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl This article mentions the following:

A new system consisting of a copper(I) complex generated in situ from a tetradentate nitrogen ligand and CuI in combination with 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) derivatives was successfully developed. The system was suitable for efficient and selective aerobic oxidation of primary benzyl and allyl alcs. with a wide range of functional groups to the corresponding aldehydes at room temperature The best result was obtained with N,N’-dimethyl-N,N’-bis(2-pyridylmethyl)ethane-1,2-diamine as the ligand and 4-OH-TEMPO as a catalyst in MeCN. In addition, high-resolution mass spectrometry, UV-visible spectroscopy, and electrochem. experiments were used to provide evidence of intermediates. In the experiment, the researchers used many compounds, for example, 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl (cas: 14691-89-5Quality Control of 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl).

4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl (cas: 14691-89-5) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Quality Control of 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Click chemistry immobilization strategies in the development of strong cation exchanger chiral stationary phases for HPLC was written by Wolrab, Denise;Fruehauf, Peter;Kohout, Michal;Lindner, Wolfgang. And the article was included in Journal of Separation Science in 2013.Name: (S)-N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide This article mentions the following:

Enantioseparation of chiral amines with HPLC has developed into a widely used anal. and preparative tool. Chiral basic mols., which act as cationic species upon protonation, are suited for an enantioselective cation exchange process. Novel strong cation exchangers (SCX) based on different 3,5-disubstituted benzoic acids functionalized with trans-(R,R)- and trans-(S,S)-2-aminocyclohexanesulfonic acid as the chiral selector (SO) and ion exchange unit were synthesized. Employing 1,3-dipolar cycloaddition (azide-yne click chem.), the SOs were immobilized onto azidopropyl-modified silica gel. This immobilization strategy enables controlled loading of the SO, and especially, high SO d. on the silica surface compared to the thiol-ene click immobilization. The performance of the novel SCX chiral stationary phases was evaluated under polar organic mode conditions with different ratios of methanol and acetonitrile, thereby changing the polarity of the bulk mobile phase. The type of co- and counterion additives employed in the mobile phase was varied as well. The influence of the formed 1,2,3-triazol spacer as well as different substitution patterns in the benzene unit on the chiral recognition properties of the SOs is discussed. In the experiment, the researchers used many compounds, for example, (S)-N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide (cas: 27262-40-4Name: (S)-N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide).

(S)-N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide (cas: 27262-40-4) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Name: (S)-N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Quinazoline derivatives by cyclodehydrogenation of N-(2-substituted aryl)piperidines was written by Mohrle, H.;Jeandree, M.. And the article was included in Zeitschrift fuer Naturforschung, B: Chemical Sciences in 1999.SDS of cas: 4045-30-1 This article mentions the following:

Dehydrogenation of 2-piperidin-1-ylbenzamides using Hg(II)-EDTA yielded the corresponding quinazolinones. Increasing size of the 4-substituent in the piperidine decreased the oxidation rate and the product yield. 2-Piperidin-1-ylbenzaldehyde oximes showed a different behavior. While 2-piperidin-1-ylbenzaldehyde oxime with Hg(II)-EDTA in water produced 2-(2-oxopiperidin-1-yl)benzaldehyde oxime in quant. yield, with 4-substituted piperidines not only a lower reaction rate but also an altered product pattern was observed The double dehydrogenation to lactams was reduced and cyclic nitrones, formed by two electron withdrawal, became dominant. The mechanism of the reactions is discussed. In the experiment, the researchers used many compounds, for example, 4,4-Dimethylpiperidine (cas: 4045-30-1SDS of cas: 4045-30-1).

4,4-Dimethylpiperidine (cas: 4045-30-1) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.SDS of cas: 4045-30-1

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Being an ADVOCATE for people with ANCA vasculitis was written by Anders, Hans-Joachim;Nakazawa, Daigo. And the article was included in Clinical Journal of the American Society of Nephrology in 2021.Recommanded Product: (2R,3S)-2-(4-(Cyclopentylamino)phenyl)-1-(2-fluoro-6-methylbenzoyl)-N-(4-methyl-3-(trifluoromethyl)phenyl)piperidine-3-carboxamide This article mentions the following:

The phase 3 clin. trial of avacopan in patients with ANCA-associated vasculitis (ADVOCATE) now reports phase 3 trial results in 331 patients with ANCA vasculitis. Eligible patients had newly diagnosed or relapsing ANCA vasculitis including granulomatosis with polyangiitis and microscopic polyangiitis, with eGFR>15 mL/min per 1.73 nr. All patients received either cyclophosphamide (followed by azathioprine) or rituximab and participants were assigned to receive either oral avacopan at a dose of 30 mg twice daily or oral prednisone on a tapering schedule. Tlie first and second primary end points were remission at week 26 and sustained remission at both weeks 26 and 52, resp. Therates of serious adverse events in the avacopan and prednisone groups (excluding worsening vasculitis) were 37.3% and 39.0%, resp. In the experiment, the researchers used many compounds, for example, (2R,3S)-2-(4-(Cyclopentylamino)phenyl)-1-(2-fluoro-6-methylbenzoyl)-N-(4-methyl-3-(trifluoromethyl)phenyl)piperidine-3-carboxamide (cas: 1346623-17-3Recommanded Product: (2R,3S)-2-(4-(Cyclopentylamino)phenyl)-1-(2-fluoro-6-methylbenzoyl)-N-(4-methyl-3-(trifluoromethyl)phenyl)piperidine-3-carboxamide).

(2R,3S)-2-(4-(Cyclopentylamino)phenyl)-1-(2-fluoro-6-methylbenzoyl)-N-(4-methyl-3-(trifluoromethyl)phenyl)piperidine-3-carboxamide (cas: 1346623-17-3) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Piperidine derivatives bearing a masked aldehyde function in the 蔚-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Recommanded Product: (2R,3S)-2-(4-(Cyclopentylamino)phenyl)-1-(2-fluoro-6-methylbenzoyl)-N-(4-methyl-3-(trifluoromethyl)phenyl)piperidine-3-carboxamide

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Design and durability study of environmental-friendly room-temperature processable icephobic coatings was written by Wu, Xinghua;Zhao, Xin;Ho, Jeffrey Weng Chye;Chen, Zhong. And the article was included in Chemical Engineering Journal (Amsterdam, Netherlands) in 2019.Name: Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate This article mentions the following:

Ice accumulation leads to improper functioning or even damages to ships, offshore platforms, sports facilities and land buildings in cold climate regions. Although fluorochems. have demonstrated attractive performance for icephobic applications, their use has been restricted due to health and environmental concerns. Here, we present a facile method to fabricate fluorine-free icephobic coatings with potential applications for outdoor facilities and structures. The coating consists of a silicone-epoxy hybrid resin, polydimethylsiloxane (PDMS) and SiO₂ nanoparticles with different sizes. Particularly, the use of different sized (10-20 nm and 200 nm) SiO₂ nanoparticles results in excellent icephobicity and mech. properties. The mech. properties and durability of the coating were analyzed according to resp. test standards and compared with other reported icephobic coatings. The durable icephobic potency of the coatings is very promising as a sustainable green solution for various practical anti-icing applications. In the experiment, the researchers used many compounds, for example, Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate (cas: 41556-26-7Name: Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate).

Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate (cas: 41556-26-7) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Name: Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Determination of ropivacaine and its metabolites in human plasma using solid phase microextraction and GC-NPD / GC-MS was written by Abdel-Rehim, Mohamed;Andersson, Mikael;Portelius, Erik;Norsten-Hoog, Carina;Blomberg, Lars G.. And the article was included in Journal of Microcolumn Separations in 2001.Application of 27262-40-4 This article mentions the following:

The performance of solid-phase microextraction (SPME) in combination with capillary gas chromatog. (CGC) to quantify ropivacaine and its metabolites in human plasma was studied. The anal. was performed using either a N P detector (NPD) or a mass-spectrometric detector. For extraction, Carbowax / divinylbenzene, polyacrylate and polydimethylsiloxane fibers were tested. Absorption and desorption times were studied for all analytes sep. The Carbowax / divinylbenzene fiber gave the highest recovery in plasma samples as compared to the other fibers. The effects of temperature, addition of salt, and agitation of the sample were studied. The validation of the method showed that the chromatog. selectivity was satisfactory and all metabolites were well separated SPME gave higher deviation as compared to published data for solid-phase and liquid-liquid extraction as sample preparation methods but the acceptance criteria for the study validation were well in line with the international criteria. The major disadvantage of SPME in quant. bioanal. is that the fiber does not withstand a complete run (standards + blanks + QC samples + patient samples). Also, the quality of fiber and the fiber length can differ from batch to batch. In the experiment, the researchers used many compounds, for example, (S)-N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide (cas: 27262-40-4Application of 27262-40-4).

(S)-N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide (cas: 27262-40-4) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Application of 27262-40-4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Total Synthesis of (-)-Senepodine G and (-)-Cermizine C was written by Snider, Barry B.;Grabowski, James F.. And the article was included in Journal of Organic Chemistry in 2007.Category: piperidines This article mentions the following:

An efficient, stereospecific synthesis of the alkaloids senepodine G chloride(I) and cermizine C (II) has been completed using the BF₃路Et₂O-promoted stereospecific addition of Me₂CuLi to an 伪,尾-unsaturated lactam, the addition of MeMgBr followed by HCl to give senepodine G (six steps, 40% overall yield), and the stereospecific NaBH₄ reduction of I to give cermizine C (seven steps, 40% overall yield). In the experiment, the researchers used many compounds, for example, (S)-2-(Piperidin-2-yl)ethanol (cas: 103639-57-2Category: piperidines).

(S)-2-(Piperidin-2-yl)ethanol (cas: 103639-57-2) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Weathering resistance of waterbased UV-cured polyurethane-acrylate coatings was written by Decker, C.;Masson, F.;Schwalm, R.. And the article was included in Polymer Degradation and Stability in 2004.Recommanded Product: 41556-26-7 This article mentions the following:

The light stability of water-based UV-cured polyurethane-acrylate (PUA) coatings has been tested in an accelerated QUV-A weatherometer. IR spectroscopy was used to monitor both the ultrafast polymerization of the acrylate double bond upon intense illumination, and the chem. changes occurring upon photoageing of 30 渭m thick clearcoats. The UV-curing reaction was hardly affected by the addition of the HALS radical scavengers and UV absorbers needed to improve the light stability of waterbased UV-cured PUA coatings. The 伪-hydroxyphenyl ketone used as photoinitiator was shown to disappear rapidly upon UV-curing and early QUV exposure, thus having no detrimental effect on the weathering resistance. The urethane linkage (C-NH) is the most sensitive to photodegradation Such waterbased PUA coatings were found to be as resistant to weathering as typical UV-cured PUA coatings. In the presence of light stabilizers, they undergo only minor chem. changes after as much as 4800 h QUV-A ageing, the surface erosion being restricted to a few micron thick layer. The observed permanency of the UV-absorber after such heavy exposure ensures a longlasting UV-screen effect of the protective coating. Water-based UV-cured PUA coatings proved to be more resistant to hydrolysis than melamine-acrylate thermosets. In the experiment, the researchers used many compounds, for example, Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate (cas: 41556-26-7Recommanded Product: 41556-26-7).

Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate (cas: 41556-26-7) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Recommanded Product: 41556-26-7

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Oxoammonium-Mediated Allylsilane-Ether Coupling Reaction was written by Carlet, Federica;Bertarini, Greta;Broggini, Gianluigi;Pradal, Alexandre;Poli, Giovanni. And the article was included in European Journal of Organic Chemistry in 2021.SDS of cas: 219543-09-6 This article mentions the following:

A new C(sp³)-H functionalization reaction consisting of the oxidative 伪-allylation of allyl- and benzyl- Me ethers has been developed. The C-C coupling could be carried out under mild conditions thanks to the use of cheap and green oxoammonium salts. The scope of the reaction was studied over 27 examples, considering the nature of the substituents on the two coupling partners. In the experiment, the researchers used many compounds, for example, 4-Acetamido-2,2,6,6-tetramethyl-1-oxopiperidinium Tetrafluoroborate (cas: 219543-09-6SDS of cas: 219543-09-6).

4-Acetamido-2,2,6,6-tetramethyl-1-oxopiperidinium Tetrafluoroborate (cas: 219543-09-6) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising 伪-glucosidase inhibitors. The former are analogs of DNJ with an improved 伪-glucosidase inhibitory profile than that of DNJ. Boisson et al.SDS of cas: 219543-09-6

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Pyrimidinopyrimidine inhibitors of ketohexokinase: Exploring the ring C2 group that interacts with Asp-27B in the ligand binding pocket was written by Maryanoff, Bruce E.;O’Neill, John C.;McComsey, David F.;Yabut, Stephen C.;Luci, Diane K.;Gibbs, Alan C.;Connelly, Margery A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Synthetic Route of C15H28N2O2 This article mentions the following:

Inhibitors of ketohexokinase (KHK) have potential for the treatment of diabetes and obesity. We have continued studies on a pyrimidinopyrimidine series of potent KHK inhibitors by exploring the 2-position substituent (R³) that interacts with Asp-27B in the ATP-binding region of KHK (viz. 1, 2; Table 1). We found that increased spacing between the terminal ammonium group and the heterocyclic scaffold (viz. 16-20), such that interaction with Asp-27B is not possible, still results in potent KHK inhibition (IC₅₀ = 15-50 nM). We propose a new interaction with Asp-194, which serves to expand the pyrimidinopyrimidine pharmacophore. In the experiment, the researchers used many compounds, for example, tert-Butyl [4,4′-bipiperidine]-1-carboxylate (cas: 171049-35-7Synthetic Route of C15H28N2O2).

tert-Butyl [4,4′-bipiperidine]-1-carboxylate (cas: 171049-35-7) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Synthetic Route of C15H28N2O2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem