Day: February 22, 2023

Overcoming epithelial-mesenchymal transition-mediated drug resistance with monensin-based combined therapy in non-small cell lung cancer was written by Ochi, Kosuke;Suzawa, Ken;Tomida, Shuta;Shien, Kazuhiko;Takano, Jui;Miyauchi, Shunsaku;Takeda, Tatsuaki;Miura, Akihiro;Araki, Kota;Nakata, Kentaro;Yamamoto, Hiromasa;Okazaki, Mikio;Sugimoto, Seiichiro;Shien, Tadahiko;Yamane, Masaomi;Azuma, Kazuo;Okamoto, Yoshiharu;Toyooka, Shinichi. And the article was included in Biochemical and Biophysical Research Communications in 2020.Synthetic Route of C21H26N2S2 This article mentions the following:

The epithelial-mesenchymal transition (EMT) is a key process in tumor progression and metastasis and is also associated with drug resistance. Thus, controlling EMT status is a research of interest to conquer the malignant tumors. A drug repositioning anal. of transcriptomic data from a public cell line database identified monensin, a widely used in veterinary medicine, as a candidate EMT inhibitor that suppresses the conversion of the EMT phenotype. Using TGF-induced EMT cell line models, the effects of monensin on the EMT status and EMT-mediated drug resistance were assessed. Tgf treatment induced EMT in non-small cell lung cancer (NSCLC) cell lines and the EGFR-mutant NSCLC cell lines with TGF-induced EMT acquired resistance to EGFR-tyrosine kinase inhibitor. The addition of monensin effectively suppressed the TGF-induced-EMT conversion, and restored the growth inhibition and the induction of apoptosis by the EGFR-tyrosine kinase inhibitor. Our data suggested that combined therapy with monensin might be a useful strategy for preventing EMT-mediated acquired drug resistance. In the experiment, the researchers used many compounds, for example, 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine (cas: 50-52-2Synthetic Route of C21H26N2S2).

10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine (cas: 50-52-2) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Synthetic Route of C21H26N2S2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

A density functional theory insight towards the rational design of ionic liquids for SO₂ capture was written by Garcia, Gregorio;Atilhan, Mert;Aparicio, Santiago. And the article was included in Physical Chemistry Chemical Physics in 2015.Name: 1-Methyl-1-propylpiperidin-1-ium bis((trifluoromethyl)sulfonyl)amide This article mentions the following:

A systematic d. functional theory (DFT) anal. was conducted to obtain mol. level information on key parameters related to efficient SO₂ capture by ionic liquids (IL). A set of 55 IL, for which high gas solubility is expected, was selected. IL SO₂ solubility was first predicted based on the COSMO-RS (conductor-like screening model for real solvents) method, which provides a good prediction of IL gas solubility data without prior exptl. knowledge of compound features. Then, interactions between SO₂ and IL were deeply analyzed using DFT simulations. Results provide valuable information about required mol. level factors to provide high SO₂ solubility in IL, crucial for further future implementation of these materials. Systematic research on IL for SO₂ capture increases knowledge about mol. level factors which could be controlled, providing an approach for the rational design of task-specific IL. In the experiment, the researchers used many compounds, for example, 1-Methyl-1-propylpiperidin-1-ium bis((trifluoromethyl)sulfonyl)amide (cas: 608140-12-1Name: 1-Methyl-1-propylpiperidin-1-ium bis((trifluoromethyl)sulfonyl)amide).

1-Methyl-1-propylpiperidin-1-ium bis((trifluoromethyl)sulfonyl)amide (cas: 608140-12-1) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Piperidine derivatives bearing a masked aldehyde function in the 蔚-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Name: 1-Methyl-1-propylpiperidin-1-ium bis((trifluoromethyl)sulfonyl)amide

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Biomarker selection and a prospective metabolite-based machine learning diagnostic for lyme disease was written by Kehoe, Eric R.;Fitzgerald, Bryna L.;Graham, Barbara;Islam, M. Nurul;Sharma, Kartikay;Wormser, Gary P.;Belisle, John T.;Kirby, Michael J.. And the article was included in Scientific Reports in 2022.Application of 94-62-2 This article mentions the following:

We provide a pipeline for data preprocessing, biomarker selection, and classification of liquid chromatog.-mass spectrometry (LCMS) serum samples to generate a prospective diagnostic test for Lyme disease. We utilize tools of machine learning (ML), e.g., sparse support vector machines (SSVM), iterative feature removal (IFR), and k-fold feature ranking to select several biomarkers and build a discriminant model for Lyme disease. We report a 98.13% test balanced success rate (BSR) of our model based on a sequestered test set of LCMS serum samples. The methodol. employed is general and can be readily adapted to other LCMS, or metabolomics, data sets. In the experiment, the researchers used many compounds, for example, (2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one (cas: 94-62-2Application of 94-62-2).

(2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one (cas: 94-62-2) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Application of 94-62-2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

The chemical development of selective and specific serotonin S₂-antagonists was written by Kennis, Ludo E. J.;Vandenberk, Jan;Boey, Jozef M.;Mertens, Jos C.;Van Heertum, Albert H. M.;Janssen, Marcel;Awouters, Frans. And the article was included in Drug Development Research in 1986.Product Details of 58113-36-3 This article mentions the following:

Four types of chem. intermediates were prepared to synthesize novel piperidine derivatives as analogs of the butyrophenones benperidol and lenperone and the diphenylbutyl neuroleptic pimozide. The 1st type, comprising benzimidazolone alkyl intermediates, yielded declenperone聽聽[63388-37-4] and milenperone聽聽[59831-64-0] and also the sym. compound domperidone聽聽[57808-66-9], which was pharmacol. unusual by its specific peripheral dopamine antagonism. Declenperone was the most potent serotonin antagonist of that series, and replacement of the benzimidazolinonepropyl by the quinazolinedioneethyl moiety led to ketanserin聽聽[74050-98-9], which was devoid of residual dopamine antagonism. Very potent serotonin S₂-antagonists were also obtained by using intermediates prepared from 2-aminoazaheterocycles. Pirenperone聽聽[75444-65-4] and setoperone聽聽[86487-64-1] had a complex pharmacol. profile, including dopamine and norepinephrine antagonism. These activity components were absent from the profile of R聽56413聽聽[87071-17-8] and ritanserin聽聽[87051-43-2], which were obtained by using the 4th intermediate, benzhydrylenepiperidine. R 56413 and ritanserin are the most specific of the presently known serotonin S₂-antagonists. Some structure-activity relations with respect to the different pharmacophores examined are discussed. In the experiment, the researchers used many compounds, for example, 4-(Bis(4-fluorophenyl)methylene)piperidine (cas: 58113-36-3Product Details of 58113-36-3).

4-(Bis(4-fluorophenyl)methylene)piperidine (cas: 58113-36-3) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Product Details of 58113-36-3

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

A Silyl Sulfinylamine Reagent Enables the Modular Synthesis of Sulfonimidamides via Primary Sulfinamides was written by Ding, Mingyan;Zhang, Ze-Xin;Davies, Thomas Q.;Willis, Michael C.. And the article was included in Organic Letters in 2022.Quality Control of Phenyl(piperidin-4-yl)methanone hydrochloride This article mentions the following:

A new N-silyl sulfinylamine reagent allows the rapid preparation of a broad range of (hetero)aryl, alkenyl, and alkyl primary sulfinamides, using Grignard, organolithium, or organozinc reagents to introduce the carbon fragment. Treatment of these primary sulfinamides with an amine in the presence of a hypervalent iodine reagent leads directly to NH-sulfonimidamides. This two-step sequence is straightforward to perform and provides a modular approach to sulfonimidamides, allowing ready variation of both reaction components, including primary and secondary amines. In the experiment, the researchers used many compounds, for example, Phenyl(piperidin-4-yl)methanone hydrochloride (cas: 25519-80-6Quality Control of Phenyl(piperidin-4-yl)methanone hydrochloride).

Phenyl(piperidin-4-yl)methanone hydrochloride (cas: 25519-80-6) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising 伪-glucosidase inhibitors. The former are analogs of DNJ with an improved 伪-glucosidase inhibitory profile than that of DNJ. Boisson et al.Quality Control of Phenyl(piperidin-4-yl)methanone hydrochloride

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Incredible colorimetric sensing behavior of pyrazole-based imine chemosensor towards copper (II) ion detection: synthesis, characterization and theoretical investigations was written by Nelson, Malini;Muniyasamy, Harikrishnan;Ongi, Pavithra;Balakrishnan, Sankar;Sepperumal, Murugesan;Ayyanar, Siva;Jegathalaprathaban, Rajesh. And the article was included in Results in Chemistry in 2022.SDS of cas: 38560-30-4 This article mentions the following:

More conjugated compounds like substituted fluorene, anthracene and pyrene based pyrazole derivatives with good yield was synthesized. All the compounds were thoroughly characterized by various spectral techniques such as NMR and mass anal. Further, the photophys. behavior of pyrazole derivatives (hybrids) upon the addition of analytes was studied using UV-visible spectroscopic techniques. All the hybrid compounds were good colorimetric sensor for copper(II) ion. AS1, AS2 and AS3 hybrid compounds possess the limit of detections as 0.62 渭M, 0.47 渭M and 4.4 渭M resp. The binding constant of the hybrid compounds AS1, AS2 and AS3 were 3.1 x 10^-2 M, 3.9 x 10^-2 M and 2.3 x 10^-2 M resp. The detection limit and binding constant of anthracene based hybrid AS2 was superior when compared to AS1 and AS3. Further, ligand to the metal charge transition of the probe with analytes were confirmed by d. function theory (DFT) through Gaussian 09 Software. In the experiment, the researchers used many compounds, for example, 1-(4-Nitrophenyl)piperidin-2-one (cas: 38560-30-4SDS of cas: 38560-30-4).

1-(4-Nitrophenyl)piperidin-2-one (cas: 38560-30-4) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.SDS of cas: 38560-30-4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

A Practical Oxidation Experiment for Undergraduate Students: Bobbitt’s Salt as a “Green” Alternative was written by Lambert, Kyle M.;Kelly, Christopher B.;Milligan, John A.;Tilley, Leon J.;Reynolds, Robert P.;McGuire, Kellen P.;Anzalone, Luigi;Del Sesto, Kimberly E.;Walsh, Sinead. And the article was included in Journal of Chemical Education in 2022.Category: piperidines This article mentions the following:

Oxidation reactions are critical components of the synthetic toolbox taught to undergraduate students during introductory organic chem. courses. However, the oxidation reactions discussed in the undergraduate curriculum are often outdated as many organic chem. textbooks emphasize chromium-based oxidants that are no longer in regular use by practitioners, which may limit an instructor’s time to allocate to discussion of other oxidants. Further, laboratory courses have since either removed oxidation experiments or replaced them with oxidative processes not discussed in lectures, thus leading to a disconnect between the two learning settings. As part of an effort to bridge this divide and modernize the oxidation reactions discussed in our curricula, we have developed a new laboratory experiment that uses a com. available oxoammonium salt (Bobbitt’s salt) to cleanly oxidize cinnamyl alc. to cinnamaldehyde. In addition to being a safe, convenient, colorimetric and “green oxidant” suitable for use in the undergraduate teaching laboratory, the hydride-transfer mechanism allows for overlap with key course concepts presented in both introductory and advanced lecture courses. The procedure is well-suited for small and large organic I, II or advanced laboratory sections alike, and can be completed within a standard 3-4 h laboratory period. Aside from exposing students to a modern green oxidation protocol, the experiment contains expanded opportunities for interpretation of ¹H NMR, ¹³C NMR, and IR spectra. An optional addendum for advanced students involving Hammett correlations was also developed. In the experiment, the researchers used many compounds, for example, 4-Acetamido-2,2,6,6-tetramethyl-1-oxopiperidinium Tetrafluoroborate (cas: 219543-09-6Category: piperidines).

4-Acetamido-2,2,6,6-tetramethyl-1-oxopiperidinium Tetrafluoroborate (cas: 219543-09-6) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Estimation of Heat Capacity of 143 Pure Ionic Liquids Using Artificial Neural Network was written by Azadfar, Roohollah;Shaabanzadeh, Masoud;Hashemi-Moghaddam, Hamid;Nafchi, Abdorreza Mohammadi. And the article was included in International Journal of Thermophysics in 2022.Computed Properties of C11H20F6N2O4S2 This article mentions the following:

Based on artificial neural network (ANN), a new model is presented to estimate the heat capacity of pure ionic liquids A database for the heat capacity of ionic liquids created by extracting exptl. data from literature covering the period from 1971 to 2021 is reported. With the presented approach, heat capacity is calculated and evaluated by source data bank for 7059 data points of 143 ionic liquids The accuracies of new ANN model are evaluated by comparing with the most commonly used correlations in the literatures, and the results reveal that the proposed network provides more accurate results than other literature correlations considered in this work. The average absolute percentage deviation from the new model is only 1.14%. In the experiment, the researchers used many compounds, for example, 1-Methyl-1-propylpiperidin-1-ium bis((trifluoromethyl)sulfonyl)amide (cas: 608140-12-1Computed Properties of C11H20F6N2O4S2).

1-Methyl-1-propylpiperidin-1-ium bis((trifluoromethyl)sulfonyl)amide (cas: 608140-12-1) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Computed Properties of C11H20F6N2O4S2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

C-5 Substituted heteroaryl 3-pyridinecarbonitriles as PKC胃 inhibitors: Part I was written by Subrath, Joan;Wang, Daniel;Wu, Biqi;Niu, Chuansheng;Boschelli, Diane H.;Lee, Julie;Yang, Xiaoke;Brennan, Agnes;Chaudhary, Divya. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2009.Quality Control of N,N-Dimethylpiperidin-4-amine This article mentions the following:

We earlier reported that 3-pyridinecarbonitriles with a 4-methylindolyl-5-amino group at C-4 and a Ph group at C-5 were inhibitors of PKC胃. Keeping the group at C-4 of the pyridine core constant, we varied the water solubilizing group on the Ph ring at C-5 and then replaced the C-5 Ph ring with several monocyclic heteroaryl rings, including furan, thiophene and pyridine. Analog 6e (I) with a 4-methylindol-5-ylamino group at C-4 and a 5-[(4-methylpiperazin-1-yl)methyl]-2-furyl group C-5 had an IC₅₀ value of 4.5 nM for the inhibition of PKC胃. In the experiment, the researchers used many compounds, for example, N,N-Dimethylpiperidin-4-amine (cas: 50533-97-6Quality Control of N,N-Dimethylpiperidin-4-amine).

N,N-Dimethylpiperidin-4-amine (cas: 50533-97-6) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N鈥揌 bond in an axial position, and the other in an equatorial position.Quality Control of N,N-Dimethylpiperidin-4-amine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Various Physical Properties of Piperic Acid: A Potential Biomaterial for Future Electronics Applications was written by Gowsia, Ishrat;Mir, Feroz A.;Banday, Javid A.. And the article was included in Journal of Electronic Materials.SDS of cas: 94-62-2 This article mentions the following:

Alk. hydrolysis of piperine yields piperic acid, which has been studied for its structural, optical, and thermal properties. X-ray diffraction studies revealed an orthorhombic crystal structure for the compound Morphol. studies carried out by SEM revealed that the compound has a fibrous structure. Fourier-transform IR spectroscopy confirms its associated vibrational groups at expected positions. In its UV-visible spectrum, the compound displayed direct forbidden and indirect allowed transitions. The optical band gap (Eg) was calculated at around 3.42 eV, indicating that indirect allowed transitions are followed by the compound Photoluminescence studies show that, with excitation in the UV region, the compound emits in the violet and red regions of the visible spectrum. M.p., stability, and other important thermodn. parameters were obtained from thermal studies of the compound Various properties shown by the compound have also been compared with piperine (parent compound). Piperic acid shows a significant improvement in these properties in comparison with piperine. Both piperine and piperic acid were subjected to theor. calculations using d. function theory. These theor. calculations and exptl. results mostly correlate with each other. Further, as per the observed properties, a diode-like structure of piperic acid was prepared and characterized for elec. properties under various illumination conditions displaying good rectifying behavior. Variation of capacitance and loss of this device was also studied and is briefly explained. The studies carried out on piperic acid project it a suitable candidate for optoelectronic device operation. In the experiment, the researchers used many compounds, for example, (2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one (cas: 94-62-2SDS of cas: 94-62-2).

(2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one (cas: 94-62-2) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.SDS of cas: 94-62-2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem