Month: December 2022

Cai, Weijie published the artcileMagnetic iron phosphide particles mediated peroxymonosulfate activation for highly efficient elimination of sulfonamide antibiotics, COA of Formula: C9H17NO, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2020), 125279, database is CAplus.

transition metal phosphides (TMP) have emerged as a promising catalyst in the environmental catalysis field due to excellent catalytic properties, high conductivity, and long stability. spherical, coral-like iron phosphide (Fe_xP) particles containing FeP orthorhombic and Fe₂P hexagonal crystals were prepared by a facile, low-temperature phosphating synthesis strategy. this heterogeneous catalyst, with unique morphol., was first used to activate peroxymonosulfate (PMS) to eliminate sulfadiazine (SDZ). Fe_xP had favorable catalytic activity to activate PMS and could eliminate SDZ up to 98.2% within 24 min. compared to Fe₂O₃ without further phosphatization treatment, P introduction in Fe₂O₃ significantly ameliorated catalytic activity for SDZ elimination; the apparent rate constant (k_obs) increased 9.1 times. Fe_xP particles exhibited a magnetic property convenient for recycling use. this feature is very different from previously reported TMP catalytic materials. four types of reactive oxygen species (sulfate radical [SO₄·^–], OH^–, singlet oxygen [¹O₂], superoxide radical [O₂^·-]) were detected and played a key role in SDZ elimination by ESR (EPR) in conjunction with radical quenching tests. results opened an avenue to develop and utilize TMP catalytic materials for environmental remediation.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C9H17NO, COA of Formula: C9H17NO.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Zhang, Xiaheng published the artcileTotal synthesis of periploside A, a unique pregnane hexasaccharide with potent immunosuppressive effects, Application of 1-(Phenylsulfinyl)piperidine, the publication is Nature Communications (2015), 5879, database is CAplus and MEDLINE.

Periploside A is a pregnane hexasaccharide identified from the Chinese medicinal plant Periploca sepium, which features a unique seven-membered formyl acetal bridged orthoester (FABO) motif and potent immunosuppressive activities. Here, we show the synthesis of this mol. in a total of 76 steps with the longest linear sequence of 29 steps and 9.2% overall yield. The FABO motif is constructed via a combination of Sinay’s and Crich’s protocol for the formation of orthoester and acetal glycosides, resp. The 2-deoxy-β-glycosidic linkages are assembled stereoselectively with judicious choice of the glycosylation methods. The epimer at the spiro-quaternary carbon in the FABO motif has also been elaborated in a stereo-controlled manner. This epimer, as well as the synthetic analogs bearing the FABO motif, retain largely the inhibitory activities of periploside A against the proliferation of T-lymphocyte, indicating the importance of the chem. connection of the FABO motif to their immunosuppressive activity.

Nature Communications published new progress about 4972-31-0. 4972-31-0 belongs to piperidines, auxiliary class Piperidine,Benzene, name is 1-(Phenylsulfinyl)piperidine, and the molecular formula is C8H19NO2, Application of 1-(Phenylsulfinyl)piperidine.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Chen, Jianfang published the artcileSynthesis of a tetrasaccharide substrate of heparanase, Quality Control of 4972-31-0, the publication is Carbohydrate Research (2008), 343(17), 2853-2862, database is CAplus and MEDLINE.

A tetrasaccharide, corresponding to the heparan sulfate heparanase substrate, namely β-D-GlcA(2S)-(1â†?)-α-D-GlcN(NS,6S)-(1â†?)-β-D-GlcA-(1â†?)-α-D-GlcN(NS,6S)-OMe, was synthesized in a convergent manner via coupling of a pair of the disaccharide building blocks as a key step.

Carbohydrate Research published new progress about 4972-31-0. 4972-31-0 belongs to piperidines, auxiliary class Piperidine,Benzene, name is 1-(Phenylsulfinyl)piperidine, and the molecular formula is C11H15NOS, Quality Control of 4972-31-0.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Zhao, Zhendong published the artcileConstruction of dual active sites on diatomic metal (FeCo-N/C-x) catalysts for enhanced Fenton-like catalysis, Recommanded Product: 2,2,6,6-Tetramethylpiperidin-4-one, the publication is Applied Catalysis, B: Environmental (2022), 121256, database is CAplus.

High metal loading of single-atom catalysts enables excellent catalytic activity, but possibly causes serious aggregation problem. Herein, a series of diat. FeCo-N/C-x (x represents metal content) were skillfully designed and applied to improve the catalytic activity for peroxymonosulfate (PMS) activation toward degrading organic micropollutants. The unprecedented dual active sites, referring to Fe(N₃)-Co(N₃) moiety and FeCo alloy, are constructed on the obtained FeCo-N/C-x, thereby exhibiting significantly greater performance toward degrading aqueous phenol (e.g., 0.316 min^-1 for FeCo-N/C-3) via PMS activation, compared with those of traditional single-atom Co-N/C (0.011 min^-1) and Fe-N/C (0.018 min^-1). Combined exptl. and theor. calculations demonstrate the independent functions of dual active sites, in which Fe(N₃)-Co(N₃) and FeCo alloy can decrease the energy barrier of O-O bond cleaving resulting in the formation of high-valent FeCo=O reactive species and singlet oxygen, resp. This study opens up a new platform toward constructing dual active sites for enhanced Fenton-like catalytic activity.

Applied Catalysis, B: Environmental published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C12H9N3O4, Recommanded Product: 2,2,6,6-Tetramethylpiperidin-4-one.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Chen, Chen published the artcileBoron regulates catalytic sites of biochar to enhance the formation of surface-confined complex for improved peroxydisulfate activation, Name: 2,2,6,6-Tetramethylpiperidin-4-one, the publication is Chemosphere (2022), 134690, database is CAplus and MEDLINE.

Biochar has been developed to activate persulfate for wastewater treatment due to its carbon essence, easily-available and low-cost. Efficiently active sites and interfacial electron transfer are highly desired for peroxydisulfate (PDS) activation. In this study, boronic ester structure and defect degree of boron-doped biochar are confirmed as activate sites to improve PDS activation. The performance of pollutants degradation is proven to have structure-activity relationships with both activate sites. Moreover, boron-doped biochar exhibits higher stability and oxidation potential by forming the surface-confined complex, promoting electron transfer from pollutants to complex. The optimized boron-doped biochar has the advantages of adapting to a broad pH range (2.9-10.0), strong resistance to Cl_– and organic matters, a low activation energy of 11.22 kJ mol^-1, and achieving the decomposition of practical dyeing wastewater. Our work provides a promising approach to regulating the interfacial catalytic sites of biochar by doping heteroatom for PDS activation in practical wastewater treatment.

Chemosphere published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C9H17NO, Name: 2,2,6,6-Tetramethylpiperidin-4-one.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Chen, Xuan published the artcilePMS activation by magnetic cobalt-N-doped carbon composite for ultra-efficient degradation of refractory organic pollutant: Mechanisms and identification of intermediates, HPLC of Formula: 826-36-8, the publication is Chemosphere (2022), 287(Part_1), 132074, database is CAplus and MEDLINE.

Refractory organic pollutant effluent has led to severe water pollution. In this study, magnetic Co-N-doped carbon hybrid catalysts (Co-NC-x) were fabricated using a facile cation exchange combined pyrolysis and self-reduction technique to activate peroxymonosulfate (PMS) for rehabilitation of the water environment. Factors affecting the catalytic activity of the Co-NC-850 were comprehensively examined 100% of RhB degradation efficiency within 20 min was achieved in the Co-NC-850/PMS system at the optimum conditions (C0 = 80 mg L-1, catalyst loading 0.025 g L-1, PMS concentration 0.8 mM, native pH and 25 °C). The ESR measurements and competitive quenching tests demonstrated that a sulfate radical (SO4â€?) and singlet oxygen (1O2) account for RhB degradation in the Co-NC-850/PMS system, and 1O2 contributed âˆ?6.2% to RhB removal. The synergistic effect of Co0 nanoparticles (NPs) and NC on Co-NC-850 might induce a predominant non-radical route to trigger PMS activation for RhB degradation Direct oxidation of O2â€? by a hydroxyl radical (•OH) might be the crucial process for forming 1O2. Magnetic response and successive cycles verified that Co-NC-850 has superior separable performance and reusability. This innovative magnetic Co-NC-850 hybrid catalyst for PMS activation delivered vast potential for disintegration of refractory organic contaminants.

Chemosphere published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C9H17NO, HPLC of Formula: 826-36-8.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Wang, Wentao published the artcileTumor-targeting multi-shelled hollow nanospheres as drug loading platforms for imaging-guided combinational cancer therapy, Synthetic Route of 826-36-8, the publication is Biomaterials Science (2020), 8(6), 1748-1758, database is CAplus and MEDLINE.

In this work, we developed multi-shelled hollow nanospheres [RGD@a_m-ZnO@CuO@Au@DOX HNSs] as multifunctional therapeutic agents to achieve effective and targeted Zn²⁺/Cu²⁺ therapy, induced drug delivery under low pH/red-light conditions, and enhanced phototherapy under single red-light. The photothermal and photodynamic performance of a_m-ZnO@CuO@Au HNSs was enhanced relative to that of a_m-ZnO nanoparticles (NPs) or a_m-ZnO@CuO HNSs by utilizing the resonance energy transfer process and broad red-light absorption. The pH-sensitive a_m-ZnO@CuO@Au HNSs were dissolved to Zn²⁺/Cu²⁺ in the acidic endosomes/lysosomes of cancer cells, resulting in a cancer cell killing effect. The release performance of doxorubicin (DOX) from RGD@a_m-ZnO@CuO@Au@DOX HNSs was evaluated under low pH and red-light-irradiated conditions, and targeting of HNSs was confirmed by dual-modal imaging (magnetic resonance/fluorescence) of the tumor area. Moreover, in vivo synergistic therapy using RGD@a_m-ZnO@CuO@Au@DOX HNSs was further evaluated in mice bearing human pulmonary adenocarcinoma (A549) cells, achieving a remarkable synergistic antitumor effect superior to that obtained by monotherapy. This study validated that RGD@a_m-ZnO@CuO@Au@DOX HNSs can be a promising candidate for efficient postoperative cancer therapy.

Biomaterials Science published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C2H4ClNO, Synthetic Route of 826-36-8.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Kitamura, Seiya published the artcileSulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry, Formula: C6H12N2O, the publication is Journal of the American Chemical Society (2020), 142(25), 10899-10904, database is CAplus and MEDLINE.

Optimization of small-mol. probes or drugs is a synthetically lengthy, challenging, and resource-intensive process. Lack of automation and reliance on skilled medicinal chemists is cumbersome in both academic and industrial settings. Here, we demonstrate a high-throughput hit-to-lead process based on the biocompatible sulfur(VI) fluoride exchange (SuFEx) click chem. A high-throughput screening hit benzyl (cyanomethyl)carbamate (K_i = 8μM) against a bacterial cysteine protease SpeB was modified with a SuFExable iminosulfur oxydifluoride [RN=S(O)F₂] motif, rapidly diversified into 460 analogs in overnight reactions, and the products were directly screened to yield drug-like inhibitors with 480-fold higher potency (K_i = 18 nM). We showed that the improved mol. is active in a bacteria-host coculture. Since this SuFEx linkage reaction succeeds on picomole scale for direct screening, we anticipate our methodol. can accelerate the development of robust biol. probes and drug candidates.

Journal of the American Chemical Society published new progress about 39546-32-2. 39546-32-2 belongs to piperidines, auxiliary class Piperidine,Amine,Amide, name is Piperidine-4-carboxamide, and the molecular formula is C6H12N2O, Formula: C6H12N2O.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Wang, Guo-Ming published the artcileThe inorganic-organic hybrid zinc phosphite poly[(μ₃-hydrogen phosphito-κ³O:O’:O”)(piperidin-1-ium-4-carboxylate-κO)zinc(II)], Application of Piperidine-4-carboxamide, the publication is Acta Crystallographica, Section C: Structural Chemistry (2014), 70(3), 289-291, database is CAplus and MEDLINE.

A new inorganic-organic hybrid zinc phosphite, [Zn(HPO₃)(C₆H₁₁NO₂)]_n, has been synthesized hydrothermally. Protonated piperidin-1-ium-4-carboxylate (PDCA) was generated in situ by hydrolysis of the piperidine-4-carboxamide precursor. The P atom possesses a typical PO₃H pseudo-pyramidal geometry. The crystal structure features an unusual (3,4)-connected two-dimensional inorganic zinc-phosphite layer, with organic PDCA ligands appended to the sheets and protruding into the interlayer region. Helical chains of opposite chirality are involved in the construction of a puckered sheet structure.

Acta Crystallographica, Section C: Structural Chemistry published new progress about 39546-32-2. 39546-32-2 belongs to piperidines, auxiliary class Piperidine,Amine,Amide, name is Piperidine-4-carboxamide, and the molecular formula is C11H16BNO3, Application of Piperidine-4-carboxamide.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Bian, Qiang published the artcileDesign, Synthesis, and Fungicidal Activities of Novel Piperidyl Thiazole Derivatives Containing Oxime Ether or Oxime Ester Moieties, Synthetic Route of 39546-32-2, the publication is Journal of Agricultural and Food Chemistry (2021), 69(13), 3848-3858, database is CAplus and MEDLINE.

To explore the influence of the positions of the two nitrogen atoms on the thiazole ring and the isoxazoline ring on the activity, a series of novel piperidyl thiazole derivatives containing oxime ether and oxime ester moieties with two nitrogen atoms on the same or opposite sides have been designed, synthesized, and first evaluated for their fungicidal activities against Phytophthora capsiciin vitro. The bioassay results showed that the target compounds possessed moderate to good fungicidal activities against P. capsici, among which oxime ether compound I shows the highest fungicidal activity in vitro (EC₅₀ = 0.0104μg/mL) which is higher than dimethomorph (EC₅₀ = 0.1148μg/mL) and diacetylenyl amide (EC₅₀ = 0.040μg/mL). Compared with oxime ether compounds (the two nitrogen atoms are on the opposite sides), the activities of oxime ester compounds were significantly reduced. It is different from the com. fungicide fluoxapiprolin, and the activities of the compounds with the two nitrogen atoms on the same side were significantly reduced compared to the compounds with the two nitrogen atoms on the opposite sides. Moreover, some compounds showed moderate to good antifungal activities in vivo against Phytophthora capsici, Pseudoperonospora cubensis, and Phytophthora infestans. SEM of compound I on the hyphae morphol. showed that compound I might cause mycelial abnormalities of P. capsici.

Journal of Agricultural and Food Chemistry published new progress about 39546-32-2. 39546-32-2 belongs to piperidines, auxiliary class Piperidine,Amine,Amide, name is Piperidine-4-carboxamide, and the molecular formula is C6H12N2O, Synthetic Route of 39546-32-2.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem