Day: December 6, 2022

Shah, Ayaz A. published the artcileBio-crude production through aqueous phase recycling of hydrothermal liquefaction of sewage sludge, Recommanded Product: 2,2,6,6-Tetramethylpiperidin-4-one, the publication is Energies (Basel, Switzerland) (2020), 13(2), 493, database is CAplus.

Hydrothermal liquefaction (HTL) is a promising technol. for the production of bio-crude. However, some unresolved issues still exist within HTL, which need to be resolved before its promotion on a com. scale. The management of the aqueous phase is one of the leading challenges related to HTL. In this study, the sewage sludge has been liquefied at 350°C with and without catalyst (K2CO3). Subsequently, aqueous phase recycling was applied to investigate the effect of recycling on bio-crude properties. Obtained results showed that the energy recovery in the form of bio-crude increased by 50% via aqueous phase recirculation, whereas nitrogen content in the bio-crude was approx. doubled after eight rounds of recycling. GCMS characterization of the aqueous phase indicated acetic acid as a major water-soluble compound, which employed as a catalyst (0.56 M), and resulted in a negligible increase in bio-crude yield. ICP-AES highlighted that the majority of the inorganics were transferred to the solid phase, while the higher accumulation of potassium and sodium was found in the aqueous phase via successive rounds of recycling.

Energies (Basel, Switzerland) published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C15H21BO2, Recommanded Product: 2,2,6,6-Tetramethylpiperidin-4-one.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Gao, Panpan published the artcilePromoted peroxymonosulfate activation into singlet oxygen over perovskite for ofloxacin degradation by controlling the oxygen defect concentration, Product Details of C9H17NO, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2019), 828-839, database is CAplus.

Recently, perovskite is becoming a promising alternative as peroxymonosulfate (PMS) activator for the remediation of organic pollutants in water. But the factor determining PMS activation efficiency of perovskite and the evolution of reactive oxygen species (ROS) remain equivocal and elusive. In this study, we proposed an oxygen defect dependent PMS activation mechanism over perovskite with the singlet oxygen (¹O₂) as the dominant ROS. Among the tested four perovskites, ofloxacin (OFX) degradation efficiency increased with the following order: LaFeO₃ < LaZnO₃ < LaMnO₃ < LaNiO₃, which agreed well with their oxygen defect amounts based on XPS and ESR (EPR) anal. The results clearly demonstrated a good relationship among oxygen defects in LaBO₃, OFX degradation efficiency and ¹O₂ concentration Moreover, ¹O₂ evolution mechanism over perovskite by decreasing the activation energy of PMS self-decomposition was proposed. The ¹O₂ mediated OFX degradation pathway was further studied by HPLC-MS technique and three-dimensional excitation-emission matrix fluorescence spectroscopy (3D EEMs). This work provides a new insight into PMS activation by perovskites and favors its application in actual water treatment.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C9H17NO, Product Details of C9H17NO.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Dhanabal, T. published the artcileGrowth, spectral, dielectric and antimicrobial studies on 4-piperidinium carboxylamide picrate crystals, Recommanded Product: Piperidine-4-carboxamide, the publication is Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (2014), 694-700, database is CAplus and MEDLINE.

Single crystal of 4-piperidinium carboxylamide picrate was grown by slow evaporation solution growth technique at ambient temperature The average dimensions of grown crystal were 0.7 × 0.3 × 0.2 cm³. The solubility of the compound was analyzed using methanol and acetone. Optical property of the compound was ascertained by UV-visible absorption spectral study. The sharp and well defined Bragg peaks observed in the powder X-ray diffraction pattern confirm its crystallinity. The different kinds of protons and carbons in the compound were confirmed by ¹H and ¹³C NMR spectral analyses. The presence of various functional groups in the compound was assigned through polarized Raman spectral study. The mech. property of the crystal was measured by Vicker’s microhardness test and the compound was found to be soft material. The dielec. constant and dielec. loss of the crystal decrease with increase in frequency. The antibacterial and antifungal activities of the crystal were studied by disk diffusion method and found that the compound shows good inhibition efficiency against various bacteria and fungi species.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about 39546-32-2. 39546-32-2 belongs to piperidines, auxiliary class Piperidine,Amine,Amide, name is Piperidine-4-carboxamide, and the molecular formula is C6H12N2O, Recommanded Product: Piperidine-4-carboxamide.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Akaji, K. published the artcileSynthesis of cyclic RGD derivatives via solid phase macrocyclization using the Heck reaction, Recommanded Product: 1-((9H-Fluoren-9-yl)methyl)piperidine, the publication is Tetrahedron (2001), 57(12), 2293-2303, database is CAplus.

A novel intramol. macrocyclization reaction on a solid support using the Heck reaction has been achieved. For head to tail cyclization on a solid support, the linear precursor was anchored to a chlorotrityl chloride resin via an ester linkage using the β-carboxyl group of Asp. The Heck coupling of acrylic acid amide to 3-iodobenzylamine on the solid support proceeds smoothly to yield a cyclic tetrapeptide derivative, which contains a new 3-substituted cinnamic acid template and Arg-Gly-Asp sequence. The macrocyclization reaction takes place considerably more rapidly on a solid support than in solution The solid phase procedure was successfully used for the construction of cyclic RGD libraries having diverse side chain structures, combined with a variety of ring sizes.

Tetrahedron published new progress about 35661-58-6. 35661-58-6 belongs to piperidines, auxiliary class Piperidine,Benzene, name is 1-((9H-Fluoren-9-yl)methyl)piperidine, and the molecular formula is C19H21N, Recommanded Product: 1-((9H-Fluoren-9-yl)methyl)piperidine.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Paul, Raymond published the artcileA new synthesis of N-substituted 3-hydroxypiperidines, Formula: C7H15NO, the publication is Compt. rend. (1945), 560-2, database is CAplus.

When a mono-alkyl- or aryltetrahydrofurfurylamine (I) is treated with 2 mols. of HBr, the ring is apparently opened and the intermediate haloamino alc. is converted to the corresponding alkyl- or aryl-3-hydroxypiperidine (II) by the action of heat and alkali. Various I were made in 2 ways: (1) by heating tetrahydrofurfuryl chloride with a large excess of primary amine at 100° for 10 h.; (2) by hydrogenation at 100°, with Raney Ni, of 1 mol. of furfural and 1 mol. of primary amine in alc. The data for the I are given below in the order b.p., d₄, n_D, and m.p. of picrate: alkyl = Me 155-6° (b₉ 40°), 0.928/21.5°, 1.4436/21.5°, 129°; Et 170-1° (b₁₂ 62°), 0.913/21°, 1.4430/21°, 98°; Pr b₁₀ 69°; Ph b₉ 154°, 1.071/21°, 1.5617/21°, 117°; benzyl b₁₁ 151°, 1.024/21°, 1.5240/21°, 135°; 3-pyridyl, b₆ 160-1°, 1.172/23°, 1.5950/23°, 161°. One mol. I is treated with 2 mols. dry HBr and warmed at 100° for 3 h. A little water is added and the solution neutralized carefully with NH₃. The Me and Et derivatives of II are salted out with K₂CO₃, the others sep. first as oils, which on treatment with concentrated KOH give II. They are colorless, very soluble in water, strongly alk. Data for derivatives of II are given in the order b.p., d₄, n_D, m.p. of HCl salt of benzoate ester; alkyl = Me b₁₆ 79°, 0.9635/16°, 1.4695/16°, 194°; Et b₁₆ 93°, 0.9580/14°, 1.4769/14°, 204°; Pr b₁₅ 77°, 0.971/15°, 1.4589/15°, 176°; Ph b₂ 145-146°, 1.092/21°, 1.5756/21°, oily, 141° (m.p. picrate); benzyl b₁₂ 155-156, 1.056/16°, 1.5402/16°, oily. The Et and Ph derivatives are identical with those found earlier. Unsubstituted I could not be converted into unsubstituted II.

Compt. rend. published new progress about 13444-24-1. 13444-24-1 belongs to piperidines, auxiliary class Piperidine,Alcohol, name is 1-Ethylpiperidin-3-ol, and the molecular formula is C7H15NO, Formula: C7H15NO.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Ledneczki, Istvan published the artcileDiscovery of novel steroidal histamine H₃ receptor antagonists/inverse agonists, Application In Synthesis of 39546-32-2, the publication is Bioorganic & Medicinal Chemistry Letters (2017), 27(19), 4525-4530, database is CAplus and MEDLINE.

Emerging from an HTS campaign, novel steroid-based histamine H₃ receptor antagonists were identified and characterized. Structural moieties of the hit compounds were combined to improve binding affinities which resulted in compound I as lead mol. During the lead optimization due to the versatile modifications of diamino steroid derivatives, several in vitro potent compounds with subnanomolar binding affinities to histamine H₃ receptors were found. The unfavorable binding to rat muscarinic receptors was successfully reduced by tuning the basicity. Compound II showed significant in vivo activity in the rat dipsogenia model and could serve as a pharmacol. tool in the future.

Bioorganic & Medicinal Chemistry Letters published new progress about 39546-32-2. 39546-32-2 belongs to piperidines, auxiliary class Piperidine,Amine,Amide, name is Piperidine-4-carboxamide, and the molecular formula is C6H12N2O, Application In Synthesis of 39546-32-2.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Nojiri, Masutoshi published the artcileCharacterization of an enantioselective amidase from Cupriavidus sp. KNK-J915 (FERM BP-10739) useful for enzymatic resolution of racemic 3-piperidinecarboxamide, Synthetic Route of 39546-32-2, the publication is Journal of Molecular Catalysis B: Enzymatic (2014), 136-142, database is CAplus.

A novel amidase (CsAM) acting on (R,S)-N-benzyl-3-piperidinecarboxamide was purified from Cupriavidus sp. KNK-J915 (FERM BP-10739) and characterized. The enzyme acts on (R,S)-N-benzyl-3-piperidinecarboxamide S-selectively to yield (R)-N-benzyl-3-piperidinecarboxamide. Anal. gel filtration column chromatog. and SDS-PAGE revealed that the enzyme is a tetramer with a subunit of approx. 47 kDa. It has a broad substrate spectrum against nitrogen-containing heterocyclic amides. Its optimal pH and temperature are 8.0-9.0 and 50 °C, resp. The CsAM gene was cloned and sequenced, and it was found to comprise 1341 bp and encode a polypeptide of 46,388 Da. The deduced amino acid sequence exhibited 78% identity to that of a putative amidase (CnAM) from Cupriavidus necator JMP134. The cultured cells of recombinant Escherichia coli producing CnAM could be used for the S-selective hydrolysis of (R,S)-N-benzyl-3-piperidinecarboxamide but could not be used for the S-selective hydrolysis of (R,S)-3-piperidinecarboxamide because of its very low level of selectivity. In contrast, the cultured cells of recombinant E. coli producing CsAM could hydrolyze both (R,S)-N-benzyl-3-piperidinecarboxamide and (R,S)-3-piperidinecarboxamide with high S-selectivity.

Journal of Molecular Catalysis B: Enzymatic published new progress about 39546-32-2. 39546-32-2 belongs to piperidines, auxiliary class Piperidine,Amine,Amide, name is Piperidine-4-carboxamide, and the molecular formula is C6H12N2O, Synthetic Route of 39546-32-2.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Son, Sang-Hyun published the artcilePre-activation of fully acetylated dodecyl thioglycosides with BSP-Tf₂O led to efficient glycosylation at low temperature, HPLC of Formula: 4972-31-0, the publication is Carbohydrate Research (2009), 344(3), 285-290, database is CAplus and MEDLINE.

Fully acetylated dodecyl thioglycosides were found to be useful as glycosyl donors by activation with 1-benzenesulfinyl piperidine (BSP) and triflic anhydride (Tf₂O) at -78 °C. The glycosyl acceptor was added to the reaction mixture at the same temperature to furnish various disaccharide, including the protected Lewis a (Le^a) trisaccharide, in good yields.

Carbohydrate Research published new progress about 4972-31-0. 4972-31-0 belongs to piperidines, auxiliary class Piperidine,Benzene, name is 1-(Phenylsulfinyl)piperidine, and the molecular formula is C8H11NO, HPLC of Formula: 4972-31-0.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Son, Sang-Hyun published the artcileStereoselective tris-glycosylation to introduce β-(1→3)-branches into gentiotetraose for the concise synthesis of phytoalexin-elicitor heptaglucoside, Application of 1-(Phenylsulfinyl)piperidine, the publication is Organic & Biomolecular Chemistry (2008), 6(8), 1441-1449, database is CAplus and MEDLINE.

Dodecyl thioglycosides (3, 4, 5) were prepared by conventional transformation of d-glucose and used as new glycosyl donors for a short-step synthesis of phytoalexin elicitor heptaglucoside. A gentio-tetraoside derivative (6) having three hydroxyl groups was synthesized by NIS-TfOH promoted glycosylate in more than 90% yield followed by selective removal of temporary protective groups. Undesired formation of α-glycosides at the introduction of β-(1→3)-branches into gentio-oligosaccharides was found to be suppressed by use of a thiophilic reagent system, BSP (1-benzenesulfinyl piperidine)-Tf₂O, giving the heptaglucoside in only four glycosylation steps.

Organic & Biomolecular Chemistry published new progress about 4972-31-0. 4972-31-0 belongs to piperidines, auxiliary class Piperidine,Benzene, name is 1-(Phenylsulfinyl)piperidine, and the molecular formula is C28H18O4, Application of 1-(Phenylsulfinyl)piperidine.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Yang, Shyh-Ming published the artcile4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable Stearoyl-CoA desaturase-1 (SCD1) inhibitors. Part 1: Urea-based analogs, SDS of cas: 1032229-33-6, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(24), 6773-6776, database is CAplus and MEDLINE.

A new series of urea-based, 4-bicyclic heteroaryl-piperidine derivatives as potent SCD1 inhibitors is described. The structure-activity relationships focused on bicyclic heteroarenes and aminothiazole-urea portions are discussed. A trend of dose-dependent decrease in body weight gain in diet-induced obese (DIO) mice is also demonstrated.

Bioorganic & Medicinal Chemistry Letters published new progress about 1032229-33-6. 1032229-33-6 belongs to piperidines, auxiliary class Metabolic Enzyme,SCD, name is 4-(2-Chlorophenoxy)-N-(3-(methylcarbamoyl)phenyl)piperidine-1-carboxamide, and the molecular formula is C14H14, SDS of cas: 1032229-33-6.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem