Day: December 1, 2022

Bobbitt, James M. published the artcileOxoammonium Salts. 6. 4-Acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium perchlorate: A stable and convenient reagent for the oxidation of alcohols. Silica gel catalysis, Computed Properties of 219543-09-6, the publication is Journal of Organic Chemistry (1998), 63(25), 9367-9374, database is CAplus.

The title piperidine-1-oxoammonium perchlorate I is a stable, nonhygroscopic oxoammonium salt that is easily prepared and can be used for the oxidation of alcs. to ketones or aldehydes in near quant. yields. The reaction is colorimetric, does not require anhydrous conditions, does not involve heavy metals, and can be carried out conveniently. Furthermore, the oxidant can be easily regenerated. The oxidation is somewhat specific in that the relative reactivities of an allyl alc. (geraniol), benzaldehyde, and 1-decanol are about 1001:0.1. The reaction is catalyzed by silica gel.

Journal of Organic Chemistry published new progress about 219543-09-6. 219543-09-6 belongs to piperidines, auxiliary class Piperidine,Fluoride,Salt,Amine,Amide, name is 4-Acetamido-2,2,6,6-tetramethyl-1-oxopiperidinium Tetrafluoroborate, and the molecular formula is C11H21BF4N2O2, Computed Properties of 219543-09-6.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Akiyama, Yoshikatsu published the artcileSynthesis of Temperature-Responsive Polymers Containing Piperidine Carboxamide and N,N-diethylcarbamoly Piperidine Moiety via RAFT Polymerization, Product Details of C6H12N2O, the publication is Macromolecular Rapid Communications (2021), 42(15), 2100208, database is CAplus and MEDLINE.

In this study, poly(N-acryloylnipecotamide) (PNANAm), poly(N-acryloylisonipecotamide) (PNAiNAm), and poly(N-acryloyl-N,N-diethylnipecotamide) (PNADNAm) are synthesized as temperature-responsive polymers using reversible addition-fragmentation chain-transfer polymerization Aqueous solutions of the three polymers are examined via temperature-dependent optical transmittance measurements. The PNANAm sample with a hydrophilic terminal group shows an upper critical solution temperature (UCST) in phosphate-buffered saline (PBS) when its mol. weight (M_n) is �7600, whereas PNANAm (M_n < 7600) is soluble The UCST is influenced by mol. weight and polymer concentration In contrast, PNANAm sample with nonionic terminal group shows UCST, when M_n is < 7600, suggesting that the terminal nonionic group possibly increases UCST of PNANAm. The urea addition experiment suggests that the driving force for expression of UCST of PNANAm is the formation of inter- and intramol. hydrogen bonds among the polymer chains. PNAiNAm is soluble in PBS but exhibits an UCST in an appropriate concentration of ammonium sulfate. In contrast, PNADNAm exhibits a lower critical solution temperature Comparing the chem. structure of these polymers and their phase transition behaviors suggests that the carboxamide group position in the piperidine ring could determine the UCST expression. The results could help design temperature-responsive polymers with a desired cloud point temperature

Macromolecular Rapid Communications published new progress about 39546-32-2. 39546-32-2 belongs to piperidines, auxiliary class Piperidine,Amine,Amide, name is Piperidine-4-carboxamide, and the molecular formula is C6H12N2O, Product Details of C6H12N2O.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Abood, L. G. published the artcilePossible role of brain mitochondria in psychopharmacology, Application In Synthesis of 13444-24-1, the publication is Journal of Neuropsychiatry (1959), 92-5, database is CAplus.

cf. CA 53, 22487b. Experiments were performed on rat-brain mitochondria to determine the presence of cholinergic receptor sites. It was observed that the distribution of tritiated N-ethyl-3-piperidyl benzilate (JB-318) (I) was similar to that of acetylcholine in the cellular fractions of rat brain. The largest concentration was found in the mitochondria. It was concluded that the cholinergic receptor sites were in this fraction or granules associated with this fraction. The inhibition of a number of drugs upon the binding of I to mitochondria was chlorpromazine 80, 3-piperidyl benzilate (JB-305) and N,N’-piperazinodiethyl dibenzilate 50, hydroxyzine 44, and dinitrophenol 20%. It was suggested that if the receptor sites are confined to cytoplasmic particles, then the phenothiazine types of tranquilizers and the psycho-mimetic agents act at the mitochondrial level of the cell.

Journal of Neuropsychiatry published new progress about 13444-24-1. 13444-24-1 belongs to piperidines, auxiliary class Piperidine,Alcohol, name is 1-Ethylpiperidin-3-ol, and the molecular formula is C7H15NO, Application In Synthesis of 13444-24-1.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Fuson, Reynold C. published the artcileRing enlargement by rearrangement of the 1,2-aminochloroalkyl group; rearrangement of 1-ethyl-2-(chloromethyl)pyrrolidine to 1-ethyl-3-chloropiperidine, HPLC of Formula: 13444-24-1, the publication is Journal of the American Chemical Society (1948), 2760-2, database is CAplus.

Reduction of 1,2-dicarbethoxypyrrole over Raney Ni in dry MeOH at 70°/1500 lb. gives 95% 1,2-dicarbethoxypyrrolidine; further reduction over Cu chromite in EtOH at 250°/100 atm. gives 31% 1-ethyl-2-hydroxypyrrolidine (I); the HCl salt and benzoate-HCl are oils; benzoate picrate, m. 170.5-1.5°. Diethyl(tetrahydrofurfuryl)amine yields 43% 1-ethyl-3-hydroxypiperidine, which forms a HCl salt (II), m. 157-8°, and a benzoate picrate, yellow, m. 181.5-2.5°. I (4 g.) in 25 ml. CHCl₃ at 0°, treated with HCl to form the HCl salt and then with 4.8 g. SOCl₂ in CHCl₃, and the mixture stirred 30 min. at room temperature and refluxed 1 hr., gives 56% 1-ethyl-2-(chloromethyl)pyrrolidine-HCl (III), m. 165-70° (heated 20°/min.), solidifies, and m. 153.5-4°; slowly heated, III contracts at 165° and m. 193.5-4°; picrate, m. 128.5-9.5°. The Me₂CO used to wash the crude III yields 1.4 g. 1-methyl-2-(chloromethyl)pyrrolidine picrate (?) (IV), m. 163.5-4.5°; it is possible that I contained some 1-ethyl-2-(hydroxymethyl)pyrrolidine. II (5 g.) and 3.7 g. SOCl₂ in 50 ml. PhMe, refluxed 3 hrs., give 87% 1-ethyl-3-chloropiperidine (V) as the HCl salt (VI), m. 193.5-4°; a mixture of III and VI also m. 193.5-4°. The base from III appears to undergo rearrangement to V as rapidly as it is liberated, an ethylenimonium ion probably being an intermediate. The base (V) from VI does not undergo rearrangement on liberation. The attempt to prepare 1-methyl-3-chloropiperidine from IV was inconclusive.

Journal of the American Chemical Society published new progress about 13444-24-1. 13444-24-1 belongs to piperidines, auxiliary class Piperidine,Alcohol, name is 1-Ethylpiperidin-3-ol, and the molecular formula is C7H15NO, HPLC of Formula: 13444-24-1.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Schultz, Otto E. published the artcileMechanism of local anesthetic action. 1. Receptor problem, SDS of cas: 13444-24-1, the publication is Pharmazie (1970), 25(8), 472-80, database is CAplus and MEDLINE.

Furfuryl alc. was treated 1 hr at -5° with PBr3 and the product treated with MeNH2 and alc. NaI 72 hr at 100-20° to give I. Treatment of I with HBr-HOAc gave a ring-opened product which was cyclized with KOH to give 63% II. Similarly prepared were 10 other compounds including III, IV, V, VI, and VII. The local anesthetic activity of these compounds vs. procaine-HCl (III) was determined III had 80% of the VIII activity. The mechanism of local anesthetic activity is discussed.

Pharmazie published new progress about 13444-24-1. 13444-24-1 belongs to piperidines, auxiliary class Piperidine,Alcohol, name is 1-Ethylpiperidin-3-ol, and the molecular formula is C8H5F3O2S, SDS of cas: 13444-24-1.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Huang, Renfeng published the artcileTuning reaction pathways of peroxymonosulfate-based advanced oxidation process via defect engineering, Name: 2,2,6,6-Tetramethylpiperidin-4-one, the publication is Cell Reports Physical Science (2021), 2(9), 100550, database is CAplus.

Peroxymonosulfate (PMS)-based advanced oxidation process (AOP) has attracted great attention as an effective technique for oxidatively decomposing organic pollutants. The PMS activation mechanisms, nevertheless, are still ambiguous in many cases, and, thus, controlling PMS activation pathways for efficient pollutant removal remains challenging. In this work, taking defective PrBa0.5Sr0.5Co1.5Fe0.5O5+v (PBSCF) as a model system, we demonstrate that oxygen vacancies (V•bulo) strongly promote PMS-based AOP, and PMS activation pathways are effectively tuned. Excessive V•bulos are found to modify the surface charge distribution, change PMS adsorption configuration, and break the S-O bond of PMS. As a result, the radical process is promoted, and the predominant nonradical activation pathway shifts from an electron transfer process to singlet oxygen formation. Our mechanistic understanding can guide the rational design of catalysts for efficient water remediation.

Cell Reports Physical Science published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C9H17NO, Name: 2,2,6,6-Tetramethylpiperidin-4-one.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Huang, Xixian published the artcileMechanism Insight into Efficient Peroxydisulfate activation by Novel Nano Zero-valent Iron Anchored yCo₃O₄ (nZVI/yCo₃O₄) Composites, Safety of 2,2,6,6-Tetramethylpiperidin-4-one, the publication is Journal of Hazardous Materials (2020), 123157, database is CAplus and MEDLINE.

Novel nano zero-valent iron anchored bio-matrix supported Co₃O₄ (nZVI/yCo₃O₄) composites were fabricated for tetracycline (TC) efficient degradation by activating peroxydisulfate (PS). The systematical characterizations verified that the nZVI/yCo₃O₄ composites with magnetism have higher surface area than yCo₃O₄ and pure Co₃O₄, contributing to more accessible active sites. Various catalytic parameters (nZVI mass ratio, leached ions, initial pH, catalyst dosage, PS concentration and coexisting anions) were thoroughly investigated. In nZVI/yCo₃O₄/PS system, 97.6%, 93.4% and 77.3% TC were degraded within 15 min at pH 3.0, 6.0 and 9.0, resp. Based on four successive degradation runs, the excellent mineralization rate and reusability of nZVI/yCo₃O₄ composites were mainly benefited from the suppressed metals leaching. The PS activated mechanisms were proposed as non-radicals (¹O₂) dominated pattern at acidic conditions and radicals (SO^{â€?/sup>-₄) predominant pattern at alk. environment, which may be highly related to the electron donating capacity of nZVI at different pH and the M(n+1)+/Mn+ redox cycling between Fe or Co metal. The plausible degradation routes of TC were presented based on the detected intermediates. Overall, the synthesized heterogeneous nZVI/yCo₃O₄ composites can efficiently active PS at a wide pH range, and further broaden the application of Co-based catalysts in PS activation.}

Journal of Hazardous Materials published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C9H17NO, Safety of 2,2,6,6-Tetramethylpiperidin-4-one.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Zhou, Chan published the artcileEfficient activation of peroxymonosulfate on CuS@MIL-101(Fe) spheres featured with abundant sulfur vacancies for coumarin degradation: Performance and mechanisms, HPLC of Formula: 826-36-8, the publication is Separation and Purification Technology (2021), 119404, database is CAplus.

For improving the catalytic activity and recyclability of CuS in Fenton-like reaction processes, novel sulfur vacancies-enriched CuS@MIL-101(Fe) was constructed, characterized, and examined as heterogeneous catalysts for activating peroxymonosulfate (PMS) to degrade coumarin (COU). Thanks to the redox pairs of Fe3+/Fe2+, Cu+/Cu2+, S2-/S2-2/S0/sulfate species, copper-iron synergistic effect and sulfur vacancies, the CuS@MIL-101(Fe) realized a complete removal of COU (30μM) in 10 min with reaction rate constant of 0.577 min-1, which was 11.1 and 17.0 times of CuS and MIL-101(Fe), resp. The effect of various exptl. conditions (i.e., initial pH, CuS@MIL-101(Fe) dosage, PMS concentration, and background anions) on COU degradation was discussed, and the stability and versatility of CuS@MIL-101(Fe) was studied as well. Radical scavenging experiments and ESR (EPR) spectroscopy identified ·OH and 1O2 as the main reactive oxygen species (ROS). Finally, the possible mechanism of higher COU degradation efficiency in the CuS@MIL-101(Fe) activated PMS system and the degradation pathways were also deeply explored. Consequently, this work provided a novel insight into construction of sulfur vacancies-enriched heterogeneous catalysts for efficiently activating PMS for refractory organic pollutants elimination.

Separation and Purification Technology published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C10H16O2, HPLC of Formula: 826-36-8.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Cai, Weijie published the artcileMagnetic iron phosphide particles mediated peroxymonosulfate activation for highly efficient elimination of sulfonamide antibiotics, COA of Formula: C9H17NO, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2020), 125279, database is CAplus.

transition metal phosphides (TMP) have emerged as a promising catalyst in the environmental catalysis field due to excellent catalytic properties, high conductivity, and long stability. spherical, coral-like iron phosphide (Fe_xP) particles containing FeP orthorhombic and Fe₂P hexagonal crystals were prepared by a facile, low-temperature phosphating synthesis strategy. this heterogeneous catalyst, with unique morphol., was first used to activate peroxymonosulfate (PMS) to eliminate sulfadiazine (SDZ). Fe_xP had favorable catalytic activity to activate PMS and could eliminate SDZ up to 98.2% within 24 min. compared to Fe₂O₃ without further phosphatization treatment, P introduction in Fe₂O₃ significantly ameliorated catalytic activity for SDZ elimination; the apparent rate constant (k_obs) increased 9.1 times. Fe_xP particles exhibited a magnetic property convenient for recycling use. this feature is very different from previously reported TMP catalytic materials. four types of reactive oxygen species (sulfate radical [SO₄·^–], OH^–, singlet oxygen [¹O₂], superoxide radical [O₂^·-]) were detected and played a key role in SDZ elimination by ESR (EPR) in conjunction with radical quenching tests. results opened an avenue to develop and utilize TMP catalytic materials for environmental remediation.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C9H17NO, COA of Formula: C9H17NO.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Zhang, Xiaheng published the artcileTotal synthesis of periploside A, a unique pregnane hexasaccharide with potent immunosuppressive effects, Application of 1-(Phenylsulfinyl)piperidine, the publication is Nature Communications (2015), 5879, database is CAplus and MEDLINE.

Periploside A is a pregnane hexasaccharide identified from the Chinese medicinal plant Periploca sepium, which features a unique seven-membered formyl acetal bridged orthoester (FABO) motif and potent immunosuppressive activities. Here, we show the synthesis of this mol. in a total of 76 steps with the longest linear sequence of 29 steps and 9.2% overall yield. The FABO motif is constructed via a combination of Sinay’s and Crich’s protocol for the formation of orthoester and acetal glycosides, resp. The 2-deoxy-β-glycosidic linkages are assembled stereoselectively with judicious choice of the glycosylation methods. The epimer at the spiro-quaternary carbon in the FABO motif has also been elaborated in a stereo-controlled manner. This epimer, as well as the synthetic analogs bearing the FABO motif, retain largely the inhibitory activities of periploside A against the proliferation of T-lymphocyte, indicating the importance of the chem. connection of the FABO motif to their immunosuppressive activity.

Nature Communications published new progress about 4972-31-0. 4972-31-0 belongs to piperidines, auxiliary class Piperidine,Benzene, name is 1-(Phenylsulfinyl)piperidine, and the molecular formula is C8H19NO2, Application of 1-(Phenylsulfinyl)piperidine.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem