Month: November 2022

Gangireddy, Madhu Sudhana Reddy published the artcileDesign, synthesis and molecular docking of piperidin-4-amine linked pyrimidine derivatives as potent anticancer agents, COA of Formula: C10H20N2O2, the main research area is aminopiperidinyl hydroxycyclohexylamino pyrimidine carboxamide preparation cytotoxicity antitumor SAR docking.

A series of rationally designed novel hybrid piperidin-4-amine linked pyrimidine derivatives I [R = n-propylamino, cyclobutylamino, phenylethylamino, etc.] were synthesized. Compound I [R = 3,4-dimethoxyphenylethylamino] was found to be most potent with (IC50 = 1.92μM, 60.94% inhibition), while I [R = 4-pyridylethylamino] (IC50 of 5.2μM, 66.45% inhibition), the second most potent among all, against HepG2 human liver cancer cell lines. Compounds I [R = 4-pyridylethylamino, 4-fluorophenylmethylamino] exhibited excellent inhibition percentages of 66.45 and 68.76 resp., compared to pos. control Paclitaxel (62.12%). In-silico target hunting for the potent compounds I [R = 3,4-dimethoxyphenylethylamino, 4-pyridylethylamino] revealed two possible targets, one was binding with human estrogen receptor and other one was inhibiting tubulin polymerization The mol. docking studies suggested that compounds I [R = 3,4-dimethoxyphenylethylamino, 4-pyridylethylamino] with hydrophobic group linked by an alkyl chain may facilitate free access in the Helix 12 domain (in determining potency plays a crucial role) in the human estrogen receptor’s active and also inhibiting the tubulin polymerase by binding site at α/β-tubuline interface at colchicine binding site.

Chemical Data Collections published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 73874-95-0 belongs to class piperidines, name is tert-Butyl piperidin-4-ylcarbamate, and the molecular formula is C10H20N2O2, COA of Formula: C10H20N2O2.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Sun, Xiaolong published the artcileThermal aging behavior characteristics of asphalt binder modified by nano-stabilizer based on DSR and AFM, Recommanded Product: Bis(2,2,6,6-tetramethylpiperidin-4-yl) decanedioate, the main research area is asphalt binder amine thermal aging dynamic.

In order to clarify the effect of thermal aging on the nano-stabilized modified asphalt binder, TINUVIN 770 (T770) hindered amine light stabilizer of nanoscale was selected as aging modifying agent to prepare modi fixed asphalt. The impact of thermal aging on the rheo logical properties of T770-modified asphalt was investigated using dynamic shear rheol. test of frequency sweep and multiple stress creep recovery test. The surface rough ness variation of T770-modified asphalt was characterized by using at. force microscope throughout the thermal aging process. Furthermore, the typical morphol. and parameter features of T770-modified asphalt were identified. The results showed that with the extension of thermal aging time, the high temperature rutting resistance of T770-modified asphalt was improved, while the unrecoverable creep compliance was degraded. When the thermal aging time exceeded 6 h, the bee structure appeared on the surface of T770-modified asphalt. Meanwhile, with the increase in thermal aging time, the special structure formed on the surface of asphalt gradually became smaller. The surface fluctuation difference of T770-modified asphalt reflected the better thermal aging resistance property of T770-modified asphalt than 70# asphalt.

Nanotechnology Reviews published new progress about Amines Role: NUU (Other Use, Unclassified), USES (Uses). 52829-07-9 belongs to class piperidines, name is Bis(2,2,6,6-tetramethylpiperidin-4-yl) decanedioate, and the molecular formula is C28H52N2O4, Recommanded Product: Bis(2,2,6,6-tetramethylpiperidin-4-yl) decanedioate.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Verma, Pritha published the artcileIridium(I)-Catalyzed α-C(sp3)-H Alkylation of Saturated Azacycles, Quality Control of 73874-95-0, the main research area is saturated azacycle regioselective alkylation alkene iridium amidoxime directing group; iridium regioselective alkylation catalyst.

Saturated azacycles are commonly encountered in bioactive compounds and approved therapeutic agents. The development of methods for functionalization of the α-methylene C-H bonds of these highly privileged building blocks is of great importance, especially in drug discovery. While much effort has been dedicated towards this goal of using a directed C-H activation approach, the development of directing groups that are both general, as well as practical, remains a significant challenge. Herein, the design and development of novel amidoxime directing groups is described for Ir(I)-catalyzed α-C(sp3)-H alkylation of saturated azacycles using readily available olefins as coupling partners. This protocol extends the scope of saturated azacycles to piperidines, azepane, and tetrahydroisoquinoline that are incompatible with our previously reported directing group. A variety of olefin coupling partners, including previously unreactive di-substituted terminal olefins and internal olefins, are compatible with this transformation. The selectivity for a branched α-C(sp3)-alkylation product is also observed for the first time when acrylate is used as the reaction partner. The development of practical, one-step installation and removal protocols further add to the utility of amidoxime directing groups.

Journal of the American Chemical Society published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 73874-95-0 belongs to class piperidines, name is tert-Butyl piperidin-4-ylcarbamate, and the molecular formula is C10H20N2O2, Quality Control of 73874-95-0.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Rajbux, Chandisree published the artcileAssessment of baby Bibs. GC-MS screening, migration into saliva and insight of toxicity with QSAR tools, HPLC of Formula: 52829-07-9, the main research area is baby bib GCMS screening artificial saliva migration QSAR toxicity.

Plastic baby Bibs are, according to the European legislation, food contact materials. Therefore, compositional and migration limits applicable to plastics should be observed This work aimed at identifying potential migrants in Bibs from European market and determining the migration into artificial saliva. Bibs were subjected to screening analyses (GC-MS). Thirty substances non-authorised in European or Swiss legislation were detected: phthalates, light stabilizers, flame retardants and photoinitiators. Irgacure 184, Cyclohexanone, Tinuvin 770, Isophorone and 9-Octadecenamide, (Z)- were detected in saliva after contact with selected Bibs. The migration values render two samples noncompliant although results should be interpreted with caution given the exptl. conditions. In order to gain insight on the toxicity of migrants, QSAR tools were applied. Substances non-evaluated or not-listed were analyzed with free software regarding their Cramer class ToxTree and their predicted mutagenicity, carcinogenicity and developmental toxicity (VEGA). Results indicate that surveillance is required: monitoring Bibs′compliance, application of GMPs and traceability.

Food Control published new progress about Alkylbenzenes Role: ANT (Analyte), ANST (Analytical Study). 52829-07-9 belongs to class piperidines, name is Bis(2,2,6,6-tetramethylpiperidin-4-yl) decanedioate, and the molecular formula is C28H52N2O4, HPLC of Formula: 52829-07-9.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Choi, Sung-Seen published the artcileAnalysis of cyclic pyrolysis products formed from amino acid monomer, Recommanded Product: Methyl 1-methylpiperidine-2-carboxylate, the main research area is amino acid pyrolysis cyclic product identification GC mass spectrometry.

Amino acid was mixed with silica and tetramethylammonium hydroxide (TMAH) to favor pyrolysis of amino acid monomer. The pyrolysis products formed from amino acid monomer were characterized by GC/MS and GC. Twenty amino acids of alanine, arginine, asparagine, aspartic acid, cysteine, glutamic acid, glutamine, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, and valine were studied. The pyrolysis products were divided into cyclic and noncyclic products. Among the 20 amino acids, arginine, asparagine, glutamic acid, glutamine, histidine, lysine, and phenylalanine generated cyclic pyrolysis products of the monomer. New cyclic pyrolysis products were formed by isolation of amino acid monomers. They commonly had polar side functional groups to 5-, 6-, or 7-membered ring structure. Arginine, asparagine, glutamic acid, glutamine, histidine, and phenylalanine generated only 5- or 6-membered ring products. However, lysine generated both 6- and 7-membered ring compounds Variations of the relative intensities of the cyclic pyrolysis products with the pyrolysis temperature and amino acid concentration were also studied.

Journal of Chromatography A published new progress about Amino acids Role: RCT (Reactant), RACT (Reactant or Reagent). 1690-74-0 belongs to class piperidines, name is Methyl 1-methylpiperidine-2-carboxylate, and the molecular formula is C8H15NO2, Recommanded Product: Methyl 1-methylpiperidine-2-carboxylate.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Roque, Jose B. published the artcileC-C Cleavage Approach to C-H Functionalization of Saturated Aza-Cycles, Quality Control of 73874-95-0, the main research area is aryl aza cyclic compound preparation visible light; fused hydroxy lactam preparation aryl halide arylation palladium catalyst; C─C cleavage; Norrish–Yang; cross-coupling; cyclic amines; palladium; strain release.

Saturated cyclic amines (aza-cycles) are ubiquitous structural motifs found in pharmaceuticals, agrochems., and bioactive natural products. Given their importance, methods that directly functionalize aza-cycles are in high demand. Herein, we disclose a fundamentally different approach to functionalizing cyclic amines which relies on C-C cleavage and attendant cross-coupling. The initial functionalization step is the generation of underexplored N-fused bicyclo α-hydroxy-β-lactams under mild, visible light conditions using a Norrish-Yang process to affect α-functionalization of saturated cyclic amines. This approach is complementary to previous methods for the C-H functionalization of aza-cycles and provides unique access to various cross-coupling adducts. In the course of these studies, we have also uncovered an orthogonal, base-promoted opening of the N-fused bicyclo α-hydroxy-β-lactams. Computational studies have provided insight into the origin of the complementary C-C cleavage processes.

ACS Catalysis published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 73874-95-0 belongs to class piperidines, name is tert-Butyl piperidin-4-ylcarbamate, and the molecular formula is C10H20N2O2, Quality Control of 73874-95-0.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Gajarska, Zuzana published the artcileIdentification of 20 polymer types by means of laser-induced breakdown spectroscopy (LIBS) and chemometrics, Product Details of C28H52N2O4, the main research area is polymer identification laser induced breakdown spectroscopy chemometric; Chemometrics; Identification; Laser-induced breakdown spectroscopy; Polymers.

Over the past few years, laser-induced breakdown spectroscopy (LIBS) has earned a lot of attention in the field of online polymer identification. Unlike the well-established near-IR spectroscopy (NIR), LIBS anal. is not limited by the sample thickness or color and therefore seems to be a promising candidate for this task. Nevertheless, the similar elemental composition of most polymers results in high similarity of their LIBS spectra, which makes their discrimination challenging. To address this problem, we developed a novel chemometric strategy based on a systematic optimization of two factors influencing the discrimination ability: the set of exptl. conditions (laser energy, gate delay, and atm.) employed for the LIBS anal. and the set of spectral variables used as a basis for the polymer discrimination. In the process, a novel concept of spectral descriptors was used to extract chem. relevant information from the polymer spectra, cluster purity based on the k-nearest neighbors (k-NN) was established as a suitable tool for monitoring the extent of cluster overlaps and an inhouse designed random forest (RDF) experiment combined with a cluster purity-governed forward selection algorithm was employed to identify spectral variables with the greatest relevance for polymer identification. Using this approach, it was possible to discriminate among 20 virgin polymer types, which is the highest number reported in the literature so far. Addnl., using the optimized exptl. conditions and data evaluation, robust discrimination performance could be achieved even with polymer samples containing carbon black or other common additives, which hints at an applicability of the developed approach to real-life samples.

Analytical and Bioanalytical Chemistry published new progress about Carbon black Role: MOA (Modifier or Additive Use), USES (Uses). 52829-07-9 belongs to class piperidines, name is Bis(2,2,6,6-tetramethylpiperidin-4-yl) decanedioate, and the molecular formula is C28H52N2O4, Product Details of C28H52N2O4.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Hou, Z. H. published the artcileEffects of radical scavenger on space charge accumulation of polypropylene/ultralow density polyethylene composites for high voltage direct current cable insulation, Related Products of piperidines, the main research area is polypropylene direct current cable insulation radical scavenger.

In this work, the space charge behavior and breakdown strength of polypropylene (PP)/ultralow d. polyethylene (ULDPE) blends and three different radical scavenger modified composites are performed at 30, 60 and 90°C. The trap distribution in the radical scavenger and the composites are investigated based on quantum chem. calculation and isothermal discharge current test. The results show that, 0.3 wt% addition of radical scavenger has little effect on the thermal and mech. property of the composites. The radical scavenger can introduce traps with different energy levels, which has greatly inhibited the space charge accumulation aggravated by the increasing temperature in the PP/ULDPE (PU) blends. Although the overall breakdown strength of the samples decreases with the rise of temperature, the performance of radical scavenger modified composites show the best, which suggests a great correlation with the traps they introduce, the mol. structure and chem. reaction of the additives themselves. The PP/ULDPE blends with 0.3 wt% C944 exhibit great potential for HVDC cable insulation.

IEEE Transactions on Dielectrics and Electrical Insulation published new progress about Attenuated-total-reflectance Fourier-transform IR spectroscopy. 52829-07-9 belongs to class piperidines, name is Bis(2,2,6,6-tetramethylpiperidin-4-yl) decanedioate, and the molecular formula is C28H52N2O4, Related Products of piperidines.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Zheng, Changsheng published the artcileA General Method for the Solid-Phase Synthesis of Unsymmetrical Tri- and Tetrasubstituted Ureas, Product Details of C21H21NO4, the main research area is urea unsym solid phase preparation.

A general method for the preparation of unsym. di-, tri-, and tetrasubstituted ureas on polymer supports is presented. Polymer-bound primary and secondary amines react with imidazolium salts (urea donors), which are generated from the reaction of N,N’-carbonyldiimidazole with primary and secondary amines followed by alkylation with MeI to give tri- and tetrasubstituted ureas in excellent yields (76-98%) and purities (80-99%).

Journal of Combinatorial Chemistry published new progress about Primary amines Role: RCT (Reactant), RACT (Reactant or Reagent). 158922-07-7 belongs to class piperidines, name is 1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-3-carboxylic acid, and the molecular formula is C21H21NO4, Product Details of C21H21NO4.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Prime, Michael E. published the artcileDiscovery and Structure-Activity Relationship of Potent and Selective Covalent Inhibitors of Transglutaminase 2 for Huntington’s Disease, Recommanded Product: Benzyl (piperidin-4-ylmethyl)carbamate, the main research area is transglutaminase inhibitor preparation; Huntington disease human structure activity.

Tissue transglutaminase 2 (TG2) is a multifunctional protein primarily known for its calcium-dependent enzymic protein crosslinking activity via iso-peptide bond formation between glutamine and lysine residues. TG2 overexpression and activity have been found to be associated with Huntington’s disease (HD); specifically, TG2 is up-regulated in the brains of HD patients and in animal models of the disease. Interestingly, genetic deletion of TG2 in two different HD mouse models, R6/1 and R6/2, results in improved phenotypes including a reduction in neuronal death and prolonged survival. Starting with phenyl-acrylamide screening hit I, the SAR of this series leading to potent and selective TG2 inhibitors is described. The suitability of the compounds as in vitro tools to elucidate the biol. of TG2 was demonstrated through mode of inhibition studies, characterization of drug like properties, and inhibition profiles in a cell lysate assay.

Journal of Medicinal Chemistry published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 132431-09-5 belongs to class piperidines, name is Benzyl (piperidin-4-ylmethyl)carbamate, and the molecular formula is C14H20N2O2, Recommanded Product: Benzyl (piperidin-4-ylmethyl)carbamate.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem