Month: November 2022

Bhavanam, Lourdu Rani published the artcileSynthesis, Characterization, Anticancer and Antimicrobial Activity Studies of Novel Isomeric 2,4-Disubstituted Ureide Derivatives of Pyrimidinopiperidines, COA of Formula: C10H20N2O2, the main research area is pyrimidinopiperidine ureide preparation anticancer antimicrobial.

A series of isomeric ureide derivatives of novel 2,4-disubstituted pyrimidinopiperidines, e.g., I were synthesized starting from 2,4-dichloropyrimidine. All the final products were purified on silica and characterized by spectral anal. Both the 2,4-disubstituted pyrimidinopiperidines were analyzed for their in vitro anticancer activity on the cell lines HCT116, MIA-PaCa2 and MDA-MB 231 by using MTT cell proliferation assay. Further, the antimicrobial studies were carried out against different bacterial and fungal strains by employing cup plate method. These compounds showed significant anticancer activity on tested three cancer cell lines and exhibited potent antimicrobial activity in tested strains of bacteria and fungi.

ChemistrySelect published new progress about Antibacterial agents. 73874-95-0 belongs to class piperidines, name is tert-Butyl piperidin-4-ylcarbamate, and the molecular formula is C10H20N2O2, COA of Formula: C10H20N2O2.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Kamsani, Supriya published the artcileDesign and synthesis of novel Bis-morpholinotriazine analogs and their antibacterial, antifungal and antioxidant studies, Category: piperidines, the main research area is bismorpholino triazine preparation antibacterial antifungal antioxidant.

A series of novel analogs of bis-morpholino-1,3,5-triazine derivatives were synthesized from cyanuric chloride as starting precursor. The products were characterized by spectral data and their biol. evaluation against microbials were reported. Antioxidant properties of these compounds were also studied.

Asian Journal of Chemistry published new progress about Antibacterial agents. 73874-95-0 belongs to class piperidines, name is tert-Butyl piperidin-4-ylcarbamate, and the molecular formula is C10H20N2O2, Category: piperidines.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Beus, Maja published the artcileChloroquine fumardiamides as novel quorum sensing inhibitors, Name: tert-Butyl piperidin-4-ylcarbamate, the main research area is Chromobacterium bactericidal quorum sensing primaquine cell communication; Chloroquine; Fumardiamide; Quinoline derivatives; Quorum quenching; Quorum sensing inhibition.

In our study, a set of twenty-six fumardiamides with a quinoline head-group were evaluated as potential QSIs. Two strains of Gram-neg. Chromobacterium violaceum (violacein-producing strain ATCC31532 and violacein-neg., mini-Tn5 mutant derivative CV026) were used as QS reporters for testing anti-QS and bactericidal activity of various quinoline fumardiamides. The initial screening of eighteen fumardiamides with primaquine, mefloquine and chloroquine scaffolds identified chloroquine derivatives as the most promising QSIs. Tail-group optimization of chloroquine fumardiamides led to the most active compounds 27, 29 and 30 bearing aminoethyl or piperidine moieties. At 400 μM concentration, these compounds inhibited the QS of C. violaceum strains in a manner similar to quercetin (the model QSI), while at the 40 μM concentration their inhibitory effect was twice less than that of quercetin. As none of the compounds displayed a bactericidal effect and that the QS inhibition was specific to the CV026 strain, our findings indicate that the structurally optimized chloroquine derivatives could function as quorum quenching (QQ) agents with a potential to block the signaling without entering the cell. In conclusion, our finding provides an important step toward the further design of agents targeting cell-to-cell communication.

Bioorganic & Medicinal Chemistry Letters published new progress about Antibacterial agents. 73874-95-0 belongs to class piperidines, name is tert-Butyl piperidin-4-ylcarbamate, and the molecular formula is C10H20N2O2, Name: tert-Butyl piperidin-4-ylcarbamate.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Weinhart, Corinna. G. published the artcileDibenzodiazepinone-type muscarinic receptor antagonists conjugated to basic peptides: Impact of the linker moiety and unnatural amino acids on M2R selectivity, Application of tert-Butyl piperidin-4-ylcarbamate, the main research area is dibenzodiazepinone peptide synthesis muscarinic receptor antagonist mol docking; solid phase synthesis peptide coupling linker; Basic amino acid; Dibenzodiazepinone derivative; Induced-fit docking; M2R antagonist; M2R selectivity; MR subtype selectivity; Muscarinic acetylcholine receptors; Peptide.

The family of human muscarinic acetylcholine receptors (MRs) is characterized by a high sequence homol. among the five subtypes (M1R-M5R), being the reason for a lack of subtype selective MR ligands. In continuation of our work on dualsteric dibenzodiazepinone-type M2R antagonists, a series of M2R ligands containing a dibenzodiazepinone pharmacophore linked to small basic peptides was synthesized (64 compounds). The linker moiety was varied with respect to length, number of basic nitrogens (0-2) and flexibility. Besides proteinogenic basic amino acids (Lys, Arg), shorter homologues of Lys and Arg, containing three and two methylene groups, resp., as well as D-configured amino acids were incorporated. The type of linker had a marked impact on M2R affinity and also effected M2R selectivity. In contrast, the structure of the basic peptide rather determined M2R selectivity than M2R affinity. For example, the most M2R selective compound (UR-CG188) with picomolar M2R affinity (pKi 9.60), exhibited a higher M2R selectivity (ratio of Ki M1R/M2R/M3R/M4R/M5R: 110:1:5200:55:2300) compared to the vast majority of reported M2R preferring MR ligands. For selected ligands, M2R antagonism was confirmed in a M2R miniG protein recruitment assay.

European Journal of Medicinal Chemistry published new progress about Hamster cell line CHO. 73874-95-0 belongs to class piperidines, name is tert-Butyl piperidin-4-ylcarbamate, and the molecular formula is C10H20N2O2, Application of tert-Butyl piperidin-4-ylcarbamate.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Arranz-Gibert, Pol published the artcileLipid Bilayer Crossing-The Gate of Symmetry. Water-Soluble Phenylproline-Based Blood-Brain Barrier Shuttles, Quality Control of 158922-07-7, the main research area is lipid bilayer permeation drug delivery phenylproline blood brain barrier.

Drug delivery to the brain can be achieved by various means, including blood-brain barrier (BBB) disruption, neurosurgical-based approaches, and mol. design. Recently, passive diffusion BBB shuttles have been developed to transport low-mol.-weight drug candidates to the brain which would not be able to cross unaided. The low water solubility of these BBB shuttles has, however, prevented them from becoming a mainstream tool to deliver cargos across membranes. Here, we describe the design, synthesis, physicochem. characterization, and BBB-transport properties of phenylproline tetrapeptides, (PhPro)4, an improved class of BBB shuttles that operates via passive diffusion. These PhPro-based BBB shuttles showed 3 orders of magnitude improvement in water solubility compared to the gold-standard (N-MePhe)4, while retaining very high transport values. Transport capacity was confirmed when two therapeutically relevant cargos, nipecotic acid and L-3,4-dihydroxyphenylalanine (i.e., L-DOPA), were attached to the shuttle. Addnl., we used the unique chiral and conformationally restricted character of the (PhPro)4 shuttle to probe its chiral interactions with the lipid bilayer of the BBB. We studied the transport properties of 16 (PhPro)4 stereoisomers using the parallel artificial membrane permeability assay and looked at differences in secondary structure. Most stereoisomers displayed excellent transport values, yet this study also revealed pairs of enantiomers with high enantiomeric discrimination and different secondary structure, where one enantiomer maintained its high transport values while the other had significantly lower values, thereby confirming that stereochem. plays a significant role in passive diffusion. This could open the door to the design of chiral and membrane-specific shuttles with potential applications in cell labeling and oncol.

Journal of the American Chemical Society published new progress about Biological permeation. 158922-07-7 belongs to class piperidines, name is 1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-3-carboxylic acid, and the molecular formula is C21H21NO4, Quality Control of 158922-07-7.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Malakoutikhah, Morteza published the artcileN-Methyl Phenylalanine-Rich Peptides as Highly Versatile Blood-Brain Barrier Shuttles, HPLC of Formula: 158922-07-7, the main research area is blood brain barrier delivery peptide drug.

Here we studied the capacity of N-MePhe-(N-MePhe)3-CONH2, Cha-(N-MePhe)3-CONH2, and 2Nal-(N-MePhe)3-CONH2 to carry various drugs (cargos) in in vitro blood-brain barrier (BBB) models in order to determine the versatility of these peptides as BBB-shuttles for drug delivery to the brain. Using SPPS, the peptides were coupled to GABA, Nip, and ALA to examine their passive BBB permeation by means of PAMPA and their lipophilicity by IAMC. Unaided, these nonpermeating drugs alone did not cross the PAMPA barrier and the BBB passively; however, the peptides tested as potential BBB shuttles transferred them by passive transfer through the PAMPA phospholipid. The permeability of peptides that showed the highest permeability in PAMPA, and Ac-N-MePhe-(N-MePhe)3-CONH2 as the parent peptide was also examined in bovine brain microvessel endothelial cells (BBMECs). These peptide-based BBB shuttles open up the possibility to overcome the formidable obstacle of the BBB, thereby achieving drug delivery to the brain.

Journal of Medicinal Chemistry published new progress about Biological permeation. 158922-07-7 belongs to class piperidines, name is 1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-3-carboxylic acid, and the molecular formula is C21H21NO4, HPLC of Formula: 158922-07-7.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Xu, Xi published the artcileDiscovery of novel glutaminase 1 allosteric inhibitor with 4-piperidinamine linker and aromatic heterocycles, COA of Formula: C10H20N2O2, the main research area is piperidinamine linker aromatic heterocycle preparation design GLS1 glutaminase inhibitor; glutaminase GLS1 allosteric inhibitor SAR metabolic stability antitumor; 4-Piperidinamine; Allosteric inhibitors; GLS1; Glutaminase 1; Glutamine metabolism.

Glutaminase 1 (GLS1) is overexpressed in multiple types of malignant tumors and is viewed as a promising target in cancer therapy. Thus, the discovery for small-mol. GLS1 inhibitors is urgent. Based on the authors’ previous study of compound I, a potent GLS1 allosteric inhibitor yet with a limited metabolic stability, a structure-based optimization was carried out, with a series of novel GLS1 allosteric inhibitors rationally designed, synthesized and biol. evaluated. Such endeavor has culminated in the identification of compound II, a promising GLS1 allosteric inhibitor with a 4-piperidinamine linker and aromatic heterocycles. Compound II displayed robust GLS1 binding affinity, superior liver microsome metabolic stability, and moderate anti-tumor activity (TGI: 47.5%) in HCT116 xenograft model with no considerable toxicity in vivo. The mechanism underlying the anti-proliferative effect of compound II on HCT116 cells was studied, revealing that the compound blocked the glutamine metabolism, induced the production of ROS, and triggered apoptosis. These findings merit further investigation of compound II as a targeted cancer therapeutic.

European Journal of Medicinal Chemistry published new progress about Allosteric modulators. 73874-95-0 belongs to class piperidines, name is tert-Butyl piperidin-4-ylcarbamate, and the molecular formula is C10H20N2O2, COA of Formula: C10H20N2O2.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Le, Chen published the artcileReclaimed water application to vegetation restoration in mining area: determination of water quality standards and optimization of moderate treatment technology, Quality Control of 52829-07-9, the main research area is water quality standard determination vegetation restoration moderate treatment technol.

Water shortage severely restricts vegetation restoration of mining area in the northwest China. Moderate treatment of reclaimed water is essential for improving the local ecol. environment. In this study, relevant water quality standards issued by the states and research results were comprehensively considered to propose a reclaimed water quality standard suitable for vegetation restoration of mining area. The available domestic sewage and mine water was moderately treated by hybrid biol. reactor system and nanofiltration membrane system, resp. The effluent quality meet the requirement of reclaimed water quality standards in this study. This study provides theor. support for vegetation restoration of mining area.

E3S Web of Conferences published new progress about Chemical oxygen demand. 52829-07-9 belongs to class piperidines, name is Bis(2,2,6,6-tetramethylpiperidin-4-yl) decanedioate, and the molecular formula is C28H52N2O4, Quality Control of 52829-07-9.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Song, Wanchao published the artcileNanofiltration desalination of reverse osmosis concentrate pretreated by advanced oxidation with ultrafiltration: Response surface optimization and exploration of membrane fouling, Formula: C28H52N2O4, the main research area is nanofiltration desalination reverse osmosis advanced oxidation ultrafiltration membrane fouling.

Reverse osmosis (RO) technique has been widely used in the advanced treatment of industrial water and wastewater. However, this process generates a large amount of reverse osmosis concentrate (ROC) which contain high salinity and organic contaminants, and therefore pose serious environmental problems. This study explored the potential of advanced oxidation processes-ultrafiltration (AOPs-UF) pretreatment system and nanofiltration (NF90, Dow Chems.) membrane system for ROC desalination. Under the optimal conditions, 78% of COD and 81% of UV254 pollutants were removed by using advanced oxidation processes with ultrafiltration pretreatment technol. Box-Behnken design (BBD) results showed that the maximum total soluble salts rejection of 97.75% was obtained under the optimized conditions of nanofiltration membrane (the 1.18 MPa operating pressure, 6.79°C feed temperature, 64.33 min filtration time). A combined membrane cleaning method was finally determined via surface morphol. characterization by the comparison of scanning electron microscope (SEM), X-ray energy dispersive anal. (EDS) and Fourier transform IR (FTIR) technique anal. The results confirmed the possibility of advanced oxidation coupled membrane treatment process to treat ROC and realize its reuse. Moreover, by evaluating the benefit calculation, it provides insights for the treatment of industrial wastewater.

Journal of Environmental Chemical Engineering published new progress about Chemical oxygen demand. 52829-07-9 belongs to class piperidines, name is Bis(2,2,6,6-tetramethylpiperidin-4-yl) decanedioate, and the molecular formula is C28H52N2O4, Formula: C28H52N2O4.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Rossino, Giacomo published the artcileNew Insights into the Opening of the Occluded Ligand-Binding Pocket of Sigma1 Receptor: Binding of a Novel Bivalent RC-33 Derivative, Recommanded Product: tert-Butyl piperidin-4-ylcarbamate, the main research area is human Sigma1 receptor ligand binding pocket opening RC33 derivative.

Significant progresses have been made to understand the mol. basis of the Sigma1 receptor (S1R) operating in normal and pathol. conditions. S1R is a transmembrane protein that participates in a wide variety of processes at the central nervous system; hence, its function has been associated with mental and neurol. disorders. Several ligands have been proposed to regulate the function of S1R revealing a high plasticity of the ligand-binding pocket. Previous drug-design studies have been mainly based on pharmacophore models; however, the recently revealed crystal structure of S1R provides an excellent opportunity for verifying previous predictions and for evaluating the binding of novel compounds Interestingly, the crystal structure shows that the binding pocket of S1R is highly occluded from solvent; therefore, it is not clear how ligands access this site. In the present work, we applied steered mol. dynamics (SMD) simulations to open the occluded ligand-binding pocket in the S1R crystal structure and to determine the preferred ligand pathway to enter and exit the binding site. The intracellular surface of the β-barrel ligand-binding region was found the most favorable route to accommodate ligands. This route supports the binding of RC-33 (our inhouse-developed S1R modulator) and a new bivalent derivative that constitutes the first divalent structure showed to interact with S1R. Free energy calculations of these compounds associated to S1R agree with exptl. Ki values and provide mol. insights of the binding mode of modulators that could access the S1R ligand-binding pocket through the cytoplasmic region.

Journal of Chemical Information and Modeling published new progress about Central nervous system. 73874-95-0 belongs to class piperidines, name is tert-Butyl piperidin-4-ylcarbamate, and the molecular formula is C10H20N2O2, Recommanded Product: tert-Butyl piperidin-4-ylcarbamate.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem