Month: November 2022

Dual kinetics of OATP2B1: Inhibitory potency and pH-dependence of OATP2B1 inhibitors was written by Sato, Ryo;Akiyoshi, Takeshi;Morita, Tokio;Katayama, Kazuhiro;Yajima, Kodai;Kataoka, Hiroki;Imaoka, Ayuko;Ohtani, Hisakazu. And the article was included in Drug Metabolism and Pharmacokinetics in 2021.Recommanded Product: 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid The following contents are mentioned in the article:

Organic anion transporting polypeptide (OATP) 2B1 is expressed in the intestine and liver, and OATP2B1-mediated transport of estrone 3-sulfate is pH-dependent and consists of: the high-affinity component (Hc) and low-affinity component (Lc). This study aimed to evaluate the influence of pH on the transport kinetics of each component, along with the inhibitory nature of ten OATP2B1 inhibitors. The Michaelis constants (K_m) were 4-fold and 1.5-fold lower at pH 6.3 than at pH 7.4, for Hc and Lc resp. The inhibitory potencies of diclofenac, indomethacin, and ibuprofen towards Hc were 1.5-4.3 fold lower at pH 6.3 than at pH 7.4. Contrastingly, inhibitory potencies towards Lc were 9.0-52 fold lower at pH 7.4. Similarly, the inhibitory effect of naproxen was stronger towards Hc at pH 6.3 and towards Lc at pH 7.4. On the other hand, celecoxib selectively inhibited Lc transport at pH 7.4. Rifampicin inhibited both components at pH 6.3 and 7.4 to a similar extent, while bromosulfophthalein, naringin, and gefitinib selectively inhibited Hc irresp. of pH. Fexofenadine inhibited neither component. In conclusion, the transport affinities of both Hc and Lc were enhanced under acidic conditions. The influence of pH on the inhibitory potency towards each component varied among the inhibitors. This study involved multiple reactions and reactants, such as 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0Recommanded Product: 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Recommanded Product: 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Epoxide hydrolase activities and epoxy fatty acids in the mosquito Culex quinquefasciatus was written by Xu, Jiawen;Morisseau, Christophe;Yang, Jun;Mamatha, Dadala M.;Hammock, Bruce D.. And the article was included in Insect Biochemistry and Molecular Biology in 2015.Application of 1222780-33-7 The following contents are mentioned in the article:

Culex mosquitoes have emerged as important model organisms for mosquito biol., and are disease vectors for multiple mosquito-borne pathogens, including West Nile virus. We characterized epoxide hydrolase activities in the mosquito Culex quinquefasciatus, which suggested multiple forms of epoxide hydrolases were present. We found EH activities on epoxy eicosatrienoic acids (EETs). EETs and other eicosanoids are well-established lipid signaling mols. in vertebrates. We showed EETs can be synthesized in vitro from arachidonic acids by mosquito lysate, and EETs were also detected in vivo both in larvae and adult mosquitoes by LC-MS/MS. The EH activities on EETs can be induced by blood feeding, and the highest activity was observed in the midgut of female mosquitoes. The enzyme activities on EETs can be inhibited by urea-based inhibitors designed for mammalian soluble epoxide hydrolases (sEH). The sEH inhibitors have been shown to play diverse biol. roles in mammalian systems, and they can be useful tools to study the function of EETs in mosquitoes. Besides juvenile hormone metabolism and detoxification, insect epoxide hydrolases may also play a role in regulating lipid signaling mols., such as EETs and other epoxy fatty acids, synthesized in vivo or obtained from blood feeding by female mosquitoes. This study involved multiple reactions and reactants, such as 1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea (cas: 1222780-33-7Application of 1222780-33-7).

1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea (cas: 1222780-33-7) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Application of 1222780-33-7

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Screening and quantification of pharmaceuticals and their metabolites in municipal wastewater treatment facilities in Guangzhou, China was written by Liu, Zhineng;Rong, Hongwei;Chu, Zhaorui;Luo, Huayong;Zhao, Meihua;Wang, Randeng;Zhang, Chaosheng. And the article was included in Desalination and Water Treatment in 2021.Application of 83799-24-0 The following contents are mentioned in the article:

The combination of qual. methods with quant. anal. of pharmaceuticals and their metabolites in wastewater treatment plants using liquid chromatog. coupled with quadrupole time-of-flight high-resolution mass spectrometry is presented. The selected pharmaceuticals were found at a low or medium level in raw wastewater, compared with previous studies around the world. The removal efficiencies of sulfamethoxazole in the four parallel biol. treatment processes were similar. Data-independent and data-dependent mass spectrometry acquisition methods (All Ions MS/MS and auto MS/MS) were employed for qual. anal. Five of the 18 tentatively identified compounds resulted from data-independent acquisition mode were confirmed with standards Thirty-nine pharmaceuticals and seven metabolites were tentatively identified using data-dependent acquisition mode. The parent pharmaceuticals and their metabolites, such as caffeine and its three metabolites (3-methylxanthine, 1,7-dimethyluric acid, and paraxanthine), were detected in wastewater. Irbesartan and valsartan were tentatively identified in both pos. and neg. modes. The present study demonstrates that both data-dependent and data-independent acquisitions are suitable and reliable for tentative determination of pharmaceuticals and their metabolites in municipal wastewater. This study involved multiple reactions and reactants, such as 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0Application of 83799-24-0).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Piperidine derivatives bearing a masked aldehyde function in the 蔚-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Application of 83799-24-0

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Solid-phase synthesis of libraries of ethynylated aminosteroid derivatives as potential antileukemic agents was written by Talbot, Amelie;Maltais, Rene;Kenmogne, Lucie Carolle;Roy, Jenny;Poirier, Donald. And the article was included in Steroids in 2016.Related Products of 86069-86-5 The following contents are mentioned in the article:

Steroids possessing an ethynyl group at position 17伪 (tertiary alcs.) are well known to be more stable than their non-ethynyl analogs (secondary alcs.). To facilitate the development of new drugs with better metabolic stability, we developed a new diethylsilyl acetylenic linker allowing us to rapidly synthesize libraries of ethynylated steroid derivatives using a solid-phase strategy. To illustrate its usefulness, this linker was used to expand the mol. diversity of a lead compound having a hydroxy acetylenic pattern and to potentially find new compounds with interesting cytotoxic activity against leukemia cell lines. Herein, we report the chem. synthesis and the characterization of three libraries of ethynylated aminosteroid derivatives using the diethylacetylenic linker. We discuss their antiproliferative activities obtained in 2 leukemia cell lines (HL-60 and Jurkat), which results provided new structure-activity relationships. We also identified a new promising aminosteroid derivative with an azetidine moiety, compound I, inhibiting 60% and 75% of HL-60 and Jurkat cell proliferation, resp., at 1 渭M. More generally, these results validate the use of a diethylsilyl acetylenic linker for researchers interested in generating libraries of alc. derivatives with better stability and drug profile. This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5Related Products of 86069-86-5).

(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Related Products of 86069-86-5

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Solid-phase synthesis of libraries of ethynylated aminosteroid derivatives as potential antileukemic agents was written by Talbot, Amelie;Maltais, Rene;Kenmogne, Lucie Carolle;Roy, Jenny;Poirier, Donald. And the article was included in Steroids in 2016.Application In Synthesis of (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid The following contents are mentioned in the article:

Steroids possessing an ethynyl group at position 17伪 (tertiary alcs.) are well known to be more stable than their non-ethynyl analogs (secondary alcs.). To facilitate the development of new drugs with better metabolic stability, we developed a new diethylsilyl acetylenic linker allowing us to rapidly synthesize libraries of ethynylated steroid derivatives using a solid-phase strategy. To illustrate its usefulness, this linker was used to expand the mol. diversity of a lead compound having a hydroxy acetylenic pattern and to potentially find new compounds with interesting cytotoxic activity against leukemia cell lines. Herein, we report the chem. synthesis and the characterization of three libraries of ethynylated aminosteroid derivatives using the diethylacetylenic linker. We discuss their antiproliferative activities obtained in 2 leukemia cell lines (HL-60 and Jurkat), which results provided new structure-activity relationships. We also identified a new promising aminosteroid derivative with an azetidine moiety, compound I, inhibiting 60% and 75% of HL-60 and Jurkat cell proliferation, resp., at 1 渭M. More generally, these results validate the use of a diethylsilyl acetylenic linker for researchers interested in generating libraries of alc. derivatives with better stability and drug profile. This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5Application In Synthesis of (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid).

(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N鈥揌 bond in an axial position, and the other in an equatorial position.Application In Synthesis of (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Investigation of the Binding Determinants of Phosphopeptides Targeted to the Src Homology 2 Domain of the Signal Transducer and Activator of Transcription 3. Development of a High-Affinity Peptide Inhibitor was written by Coleman, David R.;Ren, Zhiyong;Mandal, Pijus K.;Cameron, Arlin G.;Dyer, Garrett A.;Muranjan, Seema;Campbell, Martin;Chen, Xiaomin;McMurray, John S.. And the article was included in Journal of Medicinal Chemistry in 2005.Application In Synthesis of (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid The following contents are mentioned in the article:

As part of their research on the design of Src homol. 2 (SH2) directed peptidomimetic inhibitors of Stat3, the authors, here, describe structure-activity relationship studies that provide information on the nature of peptide-protein interactions of a high-affinity phosphopeptide, Ac-Tyr(PO₃H₂)-Leu-Pro-Gln-Thr-Val-NH₂ (peptide 1), inhibitor of Stat3 dimerization and DNA binding. There is a hydrophobic surface on the SH2 domain that can accommodate lipophilic groups on the N-terminus. Of the amino acids tested, leucine provided the highest affinity at pY+1 and its main chain NH is involved with a hydrogen bond with Stat3, presumably Ser636. Cis-3,4-Methanoproline is optimal as a backbone constraint at pY+2. The side chain amide protons of Gln are required for high-affinity interactions. The C-terminal dipeptide, Thr-Val, can be replaced with groups ranging in size from Me to benzyl. The authors synthesized a phosphopeptide incorporating groups that provided increases in affinity at each position. Thus, Ph(CH₂)₂CO-Tyr(PO₃H₂)-Leu-cis-3,4-methanoPro-Gln-NHCH₂Ph was the highest affinity peptide, exhibiting an IC₅₀ of 125 nM vs. 290 nM for peptide 1 in a fluorescence polarization assay. This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5Application In Synthesis of (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid).

(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Application In Synthesis of (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Investigation of the Binding Determinants of Phosphopeptides Targeted to the Src Homology 2 Domain of the Signal Transducer and Activator of Transcription 3. Development of a High-Affinity Peptide Inhibitor was written by Coleman, David R.;Ren, Zhiyong;Mandal, Pijus K.;Cameron, Arlin G.;Dyer, Garrett A.;Muranjan, Seema;Campbell, Martin;Chen, Xiaomin;McMurray, John S.. And the article was included in Journal of Medicinal Chemistry in 2005.COA of Formula: C21H21NO4 The following contents are mentioned in the article:

As part of their research on the design of Src homol. 2 (SH2) directed peptidomimetic inhibitors of Stat3, the authors, here, describe structure-activity relationship studies that provide information on the nature of peptide-protein interactions of a high-affinity phosphopeptide, Ac-Tyr(PO₃H₂)-Leu-Pro-Gln-Thr-Val-NH₂ (peptide 1), inhibitor of Stat3 dimerization and DNA binding. There is a hydrophobic surface on the SH2 domain that can accommodate lipophilic groups on the N-terminus. Of the amino acids tested, leucine provided the highest affinity at pY+1 and its main chain NH is involved with a hydrogen bond with Stat3, presumably Ser636. Cis-3,4-Methanoproline is optimal as a backbone constraint at pY+2. The side chain amide protons of Gln are required for high-affinity interactions. The C-terminal dipeptide, Thr-Val, can be replaced with groups ranging in size from Me to benzyl. The authors synthesized a phosphopeptide incorporating groups that provided increases in affinity at each position. Thus, Ph(CH₂)₂CO-Tyr(PO₃H₂)-Leu-cis-3,4-methanoPro-Gln-NHCH₂Ph was the highest affinity peptide, exhibiting an IC₅₀ of 125 nM vs. 290 nM for peptide 1 in a fluorescence polarization assay. This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5COA of Formula: C21H21NO4).

(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.COA of Formula: C21H21NO4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Application of a novel prioritisation strategy using non-target screening for evaluation of temporal trends (1969-2017) of contaminants of emerging concern (CECs) in archived lynx muscle tissue samples was written by Durig, Wiebke;Alygizakis, Nikiforos A.;Wiberg, Karin;Ahrens, Lutz. And the article was included in Science of the Total Environment in 2022.Safety of 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid The following contents are mentioned in the article:

Most environmental monitoring studies of contaminants of emerging concern (CECs) focus on aquatic species and target specific classes of CECs. Even with wide-scope target screening methods, relevant CECs may be missed. In this study, non-target screening (NTS) was used for tentative identification of potential CECs in muscle tissue of the terrestrial top predator Eurasian lynx (Lynx lynx). Temporal trend anal. was applied as a prioritisation tool for archived samples, using univariate statistical tests (Mann-Kendall and Spearman rank). Pooled lynx muscle tissue collected from 1969 to 2017 was analyzed with an eight-point time series using a previously validated screening workflow. Following peak detection, peak alignment, and blank subtraction, 12,941 features were considered for statistical anal. Prioritisation by time-trend anal. detected 104 and 61 features with statistically significant increasing and decreasing trends, resp. Following probable mol. formula assignment and elucidation with MetFrag, two compounds with increasing trends, and one with a decreasing trend, were tentatively identified. These results show that, despite low expected concentration levels and high matrix effects in terrestrial species, it is possible to prioritise CECs in archived lynx samples using NTS and univariate statistical approaches. This study involved multiple reactions and reactants, such as 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0Safety of 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Safety of 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Synthesis and Conformational Analysis of Efrapeptins was written by Weigelt, Sven;Huber, Thomas;Hofmann, Frank;Jost, Micha;Ritzefeld, Markus;Luy, Burkhard;Freudenberger, Christoph;Majer, Zsuzsanna;Vass, Elemer;Greie, Joerg-Christian;Panella, Lavinia;Kaptein, Bernard;Broxterman, Quirinus B.;Kessler, Horst;Altendorf, Karlheinz;Hollosi, Miklos;Sewald, Norbert. And the article was included in Chemistry – A European Journal in 2012.Synthetic Route of C21H21NO4 The following contents are mentioned in the article:

The efrapeptin family of peptide antibiotics produced by the fungus Tolypocladium niveum, and the neo-efrapeptins from the fungus Geotrichum candidum are inhibitors of F₁-ATPase with promising antitumor, antimalaria, and insecticidal activity. They are rich in C^伪-dialkyl amino acids (Aib, Iva, Acc) and contain one 尾-alanine and several pipecolic acid residues. The C-terminus bears an unusual heterocyclic cationic cap. The efrapeptins C-G and three analogs of efrapeptin C were synthesized using 伪-azido carboxylic acids as masked amino acid derivatives All compounds display inhibitory activity toward F₁-ATPase. The conformation in solution of the peptides was investigated with electronic CD spectroscopy, FT-IR spectroscopy, and VCD spectroscopy. All efrapeptins and most efrapeptin analogs were shown to adopt helical conformations in solution In the case of efrapeptin C, VCD spectra proved that a 3₁₀-helix prevails. In addition, efrapeptin C was conformationally studied in detail with NMR and mol. modeling. Besides NOE distance restraints, residual dipolar couplings (RDC) observed upon partial alignment with stretched PDMS gels were used for the conformational anal. and confirmed the 3₁₀-helical conformation. Safety: caution is advised with low-mol.-weight azido compounds This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5Synthetic Route of C21H21NO4).

(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Synthetic Route of C21H21NO4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Synthesis and Conformational Analysis of Efrapeptins was written by Weigelt, Sven;Huber, Thomas;Hofmann, Frank;Jost, Micha;Ritzefeld, Markus;Luy, Burkhard;Freudenberger, Christoph;Majer, Zsuzsanna;Vass, Elemer;Greie, Joerg-Christian;Panella, Lavinia;Kaptein, Bernard;Broxterman, Quirinus B.;Kessler, Horst;Altendorf, Karlheinz;Hollosi, Miklos;Sewald, Norbert. And the article was included in Chemistry – A European Journal in 2012.Reference of 86069-86-5 The following contents are mentioned in the article:

The efrapeptin family of peptide antibiotics produced by the fungus Tolypocladium niveum, and the neo-efrapeptins from the fungus Geotrichum candidum are inhibitors of F₁-ATPase with promising antitumor, antimalaria, and insecticidal activity. They are rich in C^伪-dialkyl amino acids (Aib, Iva, Acc) and contain one 尾-alanine and several pipecolic acid residues. The C-terminus bears an unusual heterocyclic cationic cap. The efrapeptins C-G and three analogs of efrapeptin C were synthesized using 伪-azido carboxylic acids as masked amino acid derivatives All compounds display inhibitory activity toward F₁-ATPase. The conformation in solution of the peptides was investigated with electronic CD spectroscopy, FT-IR spectroscopy, and VCD spectroscopy. All efrapeptins and most efrapeptin analogs were shown to adopt helical conformations in solution In the case of efrapeptin C, VCD spectra proved that a 3₁₀-helix prevails. In addition, efrapeptin C was conformationally studied in detail with NMR and mol. modeling. Besides NOE distance restraints, residual dipolar couplings (RDC) observed upon partial alignment with stretched PDMS gels were used for the conformational anal. and confirmed the 3₁₀-helical conformation. Safety: caution is advised with low-mol.-weight azido compounds This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5Reference of 86069-86-5).

(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Reference of 86069-86-5

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem