Month: November 2022

Synthetic study on homophymine A: Stereoselective synthesis of unusual amino acids and solid phase synthesis of the cyclic fragment was written by Takeda, Sho;Tokairin, Yoshinori;Kikuchi, Mari;Konno, Hiroyuki. And the article was included in Peptide Science in 2013.Category: piperidines The following contents are mentioned in the article:

The synthesis of the cyclic fragment of homophymine A was conducted by Fmoc-SPPS. Four building blocks were prepared from amino acids via stereocontrolled synthesis. Identification of the relative configuration of AHDH was performed using “J-based configuration anal.”. This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5Category: piperidines).

(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising α-glucosidase inhibitors. The former are analogs of DNJ with an improved α-glucosidase inhibitory profile than that of DNJ. Boisson et al.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Regioselective reduction of bipyridines was written by Plaquevent, Jean Christophe;Chichaoui, Ilhame. And the article was included in Tetrahedron Letters in 1993.Product Details of 31251-28-2 The following contents are mentioned in the article:

A method for the specific reduction of bipyridines through the use of the N-oxo derivatives is described. E.g., oxidation of 2,4′-bipyridine by m-chloroperbenzoic acid gave the N-oxo derivative, which was hydrogenated (H₂, Pd) to give 38% piperidinylpyridine I. This study involved multiple reactions and reactants, such as 3-(Piperidin-3-yl)pyridine (cas: 31251-28-2Product Details of 31251-28-2).

3-(Piperidin-3-yl)pyridine (cas: 31251-28-2) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Product Details of 31251-28-2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Preparation and applications of pentafluorophenyl esters of 9-fluorenylmethyloxycarbonyl amino acids for peptide synthesis was written by Kisfaludy, Lajos;Schon, Istvan. And the article was included in Synthesis in 1983.Category: piperidines The following contents are mentioned in the article:

Twenty-three 9-fluorenylmethyloxycarbonyl (Fmoc) amino acid pentafluorophenyl esters were prepared in 55-99% yields by esterifying the corresponding Fmoc amino acids with C₆F₅OH by DCC. The esters were used in the stepwise synthesis of Fmoc-Gly-Trp-Leu-Asp-NH₂. This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5Category: piperidines).

(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Preparation and applications of pentafluorophenyl esters of 9-fluorenylmethyloxycarbonyl amino acids for peptide synthesis was written by Kisfaludy, Lajos;Schon, Istvan. And the article was included in Synthesis in 1983.Recommanded Product: (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid The following contents are mentioned in the article:

Twenty-three 9-fluorenylmethyloxycarbonyl (Fmoc) amino acid pentafluorophenyl esters were prepared in 55-99% yields by esterifying the corresponding Fmoc amino acids with C₆F₅OH by DCC. The esters were used in the stepwise synthesis of Fmoc-Gly-Trp-Leu-Asp-NH₂. This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5Recommanded Product: (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid).

(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Recommanded Product: (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Correction to Optimized Inhibitors of Soluble Epoxide Hydrolase Improve in Vitro Target Residence Time and in Vivo Efficacy [Erratum to document cited in CA161:346388] was written by Lee, Kin Sing Stephen;Liu, Jun-Yan;Wagner, Karen M.;Pakhomova, Svetlana;Dong, Hua;Morisseau, Christophe;Fu, Samuel H.;Yang, Jun;Wang, Peng;Ulu, Arzu;Mate, Christina A.;Nguyen, Long V.;Hwang, Sung Hee;Edin, Matthew L.;Mara, Alexandria A.;Wulff, Heike;Newcomer, Marcia E.;Zeldin, Darryl C.;Hammock, Bruce D.. And the article was included in Journal of Medicinal Chemistry in 2018.Computed Properties of C16H20F3N3O3 The following contents are mentioned in the article:

In the legend within Figure S11, the yellowish green line with solid triangle should be inhibitor 21 instead of inhibitor 19, while green line with open triangle should be inhibitor 19 instead of inhibitor 21. The corresponding structures should be swapped too. The correct Figure S11 is provided here. This study involved multiple reactions and reactants, such as 1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea (cas: 1222780-33-7Computed Properties of C16H20F3N3O3).

1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea (cas: 1222780-33-7) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Computed Properties of C16H20F3N3O3

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Discovery of SARxxxx92, a pan-PIM kinase inhibitor, efficacious in a KG1 tumor model was written by Barberis, Claude;Erdman, Paul;Czekaj, Mark;Fire, Luke;Pribish, James;Tserlin, Elina;Maniar, Sachin;Batchelor, Joseph D.;Liu, Jinyu;Patel, Vinod F.;Hebert, Andrew;Levit, Mikhail;Wang, Anlai;Sun, Frank;Huang, Shih-Min A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020.Product Details of 882033-93-4 The following contents are mentioned in the article:

N-substituted azaindoles were discovered as potent pan-PIM inhibitors. Lead optimization, guided by structure and focused on physico-chem. properties allowed us to solve inherent hERG and permeability liabilities, and provided compound I, which subsequently impacted KG-1 tumor growth in a mouse model. This study involved multiple reactions and reactants, such as (3S,4R)-rel-tert-Butyl 3-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate (cas: 882033-93-4Product Details of 882033-93-4).

(3S,4R)-rel-tert-Butyl 3-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate (cas: 882033-93-4) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Product Details of 882033-93-4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Synthesis of methyl 1-(3,4-dichlorobenzyl)hexahydro-2,3-dioxo-4-pyridinecarboxylate was written by Schwan, Thomas J.;Gray, Joseph E.;Wright, George C.. And the article was included in Journal of Pharmaceutical Sciences in 1979.Safety of Ethyl 2,3-dioxopiperidine-4-carboxylate The following contents are mentioned in the article:

Me 1-(3,4-dichlorbenzyl)hexahydro-2,3-dioxo-4-pyridinecarboxylate (I) was prepared by alkylation of Me hexahydro-2,3-dioxo-4-pyridinecarboxylate with α,3,4-trichlorotoluene. I was active against pathogenic yeast species, some dermatophytic fungi and Aspergillus niger. This study involved multiple reactions and reactants, such as Ethyl 2,3-dioxopiperidine-4-carboxylate (cas: 30727-21-0Safety of Ethyl 2,3-dioxopiperidine-4-carboxylate).

Ethyl 2,3-dioxopiperidine-4-carboxylate (cas: 30727-21-0) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Safety of Ethyl 2,3-dioxopiperidine-4-carboxylate

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Synthesis and evaluation of 3-aryl piperidine analogs as potent and efficacious dopamine D₄ receptor agonists was written by Wang, Xueqing;Bhatia, Pramila A.;Daanen, Jerome F.;Latsaw, Steve P.;Rohde, Jeffrey;Kolasa, Teodozyi;Hakeem, Ahmed A.;Matulenko, Mark A.;Nakane, Masaki;Uchic, Marie E.;Miller, Loan N.;Chang, Renjie;Moreland, Robert B.;Brioni, Jorge D.;Stewart, Andrew O.. And the article was included in Bioorganic & Medicinal Chemistry in 2005.Electric Literature of C10H14N2 The following contents are mentioned in the article:

A series of 3-aryl piperidine analogs with 2-piperidinoalkylamino or 2-piperidinoalkyloxy fused bicyclic rings were prepared and found to be potent and efficacious human dopamine D₄ agonists. The synthesis and structure-activity relationship (SAR) studies that led to the identification of these compounds are discussed. This study involved multiple reactions and reactants, such as 3-(Piperidin-3-yl)pyridine (cas: 31251-28-2Electric Literature of C10H14N2).

3-(Piperidin-3-yl)pyridine (cas: 31251-28-2) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Electric Literature of C10H14N2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Total synthesis and structure assignment of papuamide B, a potent marine cyclodepsipeptide with anti-HIV properties was written by Xie, Weiqing;Ding, Derong;Li, Guangyu;Ma, Dawei. And the article was included in Angewandte Chemie, International Edition in 2008.Formula: C21H21NO4 The following contents are mentioned in the article:

The first total synthesis of papuamide B, a cyclic peptide isolated from a marine sponge, has been achieved. The configuration of three stereogenic centers of its dienoic acid unit has been established by comparison to a series of stereoisomers of known configuration, and the stereochem. of its 2,3-diaminobutanoic acid segment has been revised. This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5Formula: C21H21NO4).

(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Formula: C21H21NO4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Total synthesis and structure assignment of papuamide B, a potent marine cyclodepsipeptide with anti-HIV properties was written by Xie, Weiqing;Ding, Derong;Li, Guangyu;Ma, Dawei. And the article was included in Angewandte Chemie, International Edition in 2008.Application In Synthesis of (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid The following contents are mentioned in the article:

The first total synthesis of papuamide B, a cyclic peptide isolated from a marine sponge, has been achieved. The configuration of three stereogenic centers of its dienoic acid unit has been established by comparison to a series of stereoisomers of known configuration, and the stereochem. of its 2,3-diaminobutanoic acid segment has been revised. This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5Application In Synthesis of (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid).

(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Application In Synthesis of (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem