Day: November 22, 2022

Histamine receptors rapidly desensitize without altering nerve-evoked contractions in murine urinary bladder smooth muscle was written by Jones, B. Malique;Mingin, Gerald C.;Tykocki, Nathan R.. And the article was included in American Journal of Physiology in 2022.Related Products of 83799-24-0 The following contents are mentioned in the article:

Histamine has been implicated in urinary bladder dysfunction as an inflammatory mediator driving sensory nerve hypersensitivity. However, the direct influence of histamine on smooth muscle has not been thoroughly investigated. We hypothesized that histamine directly contracts urinary bladder smooth muscle (UBSM) independent of effects on nerves. Single cell quant. RT-PCR determined that only histamine H1 and H2 receptors were expressed on UBSM cells. In isolated tissue bath experiments, histamine (200μM) caused a highly variable and rapidly desensitizing contraction that was completely abolished by the H1 receptor antagonist fexofenadine (5μM) and the Gq/11 inhibitor YM254890 (1μM). Neither the muscarinic receptor antagonist atropine (1μM), the Na+ channel blocker tetrodotoxin (1μM), nor the transient receptor potential vanilloid type 1 antagonist capsazepine (10μM) altered responses to histamine, suggesting that nerve activation was not involved. UBSM desensitization to histamine was not due to receptor internalization, as neither the cholesterol-depleting agent methyl-β-cyclodextrin (10 mM), the dynamin-mediated endocytosis inhibitor dynasore (100μM), nor the clathrin-mediated endocytosis inhibitor pitstop2 (15μM) augmented or prolonged histamine contractions. Buffer from desensitized tissues still contracted histamine-naive tissues, revealing that histamine was not metabolized. Prolonged exposure to histamine also had no effect on contractions due to elec. field stimulation, suggesting that both efferent nerve and UBSM excitability were unchanged. Together, these data suggest that histamine, although able to transiently contract UBSM, does not have a lasting effect on UBSM excitability or responses to efferent nerve input. Thus, any acute effects of histamine directly on UBSM contractility are unlikely to alter urinary bladder function. This study involved multiple reactions and reactants, such as 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0Related Products of 83799-24-0).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Related Products of 83799-24-0

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Network Pharmacology Study to Elucidate the Key Targets of Underlying Antihistamines against COVID-19 was written by Oh, Ki-Kwang;Adnan, Md.;Cho, Dong-Ha. And the article was included in Current Issues in Molecular Biology in 2022.Quality Control of 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid The following contents are mentioned in the article:

Antihistamines have potent efficacy to alleviate COVID-19 (Coronavirus disease 2019) symptoms such as anti-inflammation and as a pain reliever. However, the pharmacol. mechanism(s), key target(s), and drug(s) are not documented well against COVID-19. Thus, we investigated to decipher the most significant components and how its research methodol. was utilized by network pharmacol. The list of 32 common antihistamines on the market were retrieved via drug browsing databases. The targets associated with the selected antihistamines and the targets that responded to COVID-19 infection were identified by the Similarity Ensemble Approach (SEA), SwissTargetPrediction (STP), and PubChem, resp. We described bubble charts, the Pathways-Targets-Antihistamines (PTA) network, and the protein-protein interaction (PPI) network on the RPackage via STRING database. Furthermore, we utilized the AutoDock Tools software to perform mol. docking tests (MDT) on the key targets and drugs to evaluate the network pharmacol. perspective. The final 15 targets were identified as core targets, indicating that Neuroactive ligand-receptor interaction might be the hub-signaling pathway of antihistamines on COVID-19 via bubble chart. The PTA network was constructed by the RPackage, which identified 7 pathways, 11 targets, and 30 drugs. In addition, GRIN2B, a key target, was identified via topol. anal. of the PPI network. Finally, we observed that the GRIN2B-Loratidine complex was the most stable docking score with -7.3 kcal/mol through mol. docking test. Our results showed that Loratadine might exert as an antagonist on GRIN2B via the neuroactive ligand-receptor interaction pathway. To sum up, we elucidated the most potential antihistamine, a key target, and a key pharmacol. pathway as alleviating components against COVID-19, supporting scientific evidence for further research. This study involved multiple reactions and reactants, such as 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0Quality Control of 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Quality Control of 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

A decision tree framework to support design, operation, and performance assessment of constructed wetlands for the removal of emerging organic contaminants was written by Ilyas, Huma;Masih, Ilyas;van Hullebusch, Eric D.. And the article was included in Science of the Total Environment in 2021.Recommanded Product: 83799-24-0 The following contents are mentioned in the article:

There is an increasing focus on research related to the removal of emerging organic contaminants (EOCs) from wastewater by using constructed wetlands (CWs). However, research is lacking on translating the available scientific evidence into decision support tools. In this paper, a novel decision tree framework is developed and demonstrated. The proposed framework consists of five steps: (1) generate a list of EOCs by the anal. of the wastewater; (2) select the best type of CW for each of the selected EOCs; (3) select a final type of CW for the removal of the selected EOCs; (4) identify detailed design and operational features of the proposed CW such as, depth, area, plants, support matrix, hydraulic loading rate, organic loading rate, and hydraulic retention time; and (5) assess the expected removal efficiency of EOCs in the selected CW. A novel decision support tool, named as DTFT-CW, was developed to generate data and information for the application of the proposed decision tree framework. DTFT-CW (given as a supplementary material) was developed using Microsoft Excel 2016 to support decisions on the design, operation, and performance of CWs for the removal of 59 EOCs (33 pharmaceuticals-PhCs, 15 personal care products-PCPs, and 11 steroidal hormones-SHs). The paper demonstrates the usefulness of the developed decision-making tools by considering 19 EOCs (13 PhCs, one PCPs, and five SHs) as an example, which pose high environmental risk and are on the European Union watch list (six of the 19 EOCs). An integrated design of HCW (combining vertical flow CW, horizontal flow CW-HFCW, and free water surface CW) is recommended for the treatment of multiple EOCs instead of a single type of CW such as HFCW that is most widely used in practice. The proposed tools could be useful for decision makers such as policy makers, design engineers, and researchers. This study involved multiple reactions and reactants, such as 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0Recommanded Product: 83799-24-0).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Recommanded Product: 83799-24-0

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Quantitative prediction of P-glycoprotein-mediated drug-drug interactions and intestinal absorption using humanized mice was written by Miyake, Taiji;Tsutsui, Haruka;Haraya, Kenta;Tachibana, Tatsuhiko;Morimoto, Kayoko;Takehara, Shoko;Ayabe, Miho;Kobayashi, Kaoru;Kazuki, Yasuhiro. And the article was included in British Journal of Pharmacology in 2021.Category: piperidines The following contents are mentioned in the article:

P-glycoprotein (P-gp) exhibits a broad substrate specificity and affects pharmacokinetics, especially intestinal absorption. However, prediction, in vivo, of P-gp-mediated drug-drug interaction (DDI) and non-linear absorption at the preclin. stage, is challenging. Here we evaluate the use of human MDR1 mouse artificial chromosome (hMDR1-MAC) mice carrying human P-gp and lacking their own murine P-gp to quant. predict human P-gp-mediated DDI and non-linear absorption. The P-gp substrates (aliskiren, betrixaban, celiprolol, digoxin, fexofenadine and talinolol) were administered orally to wild-type, Mdr1a/b-knockout (KO) and hMDR1-MAC mice, and their plasma concentrations were measured. We calculated the ratio of area under the curve (AUCR) in mice (AUC_Mdr1a/b-KO/AUC_wild-type or AUC_Mdr1a/b-KO/AUC_hMDR1-MAC) estimated as attributable to complete P-gp inhibition and the human AUCR with and without P-gp inhibitor administration. The correlations of AUCR_human with AUCR_wild-type and AUCRhMDR1-MAC were investigated. For aliskiren, betrixaban and celiprolol, the K_m and V_max values for P-gp in hMDR1-MAC mice and humans were optimized from different dosing studies using GastroPlus. The correlations of K_m and V_max for P-gp between human and hMDR1-MAC mice were investigated. A better correlation between AUCR_human and AUCRhMDR1-MAC (R² = 0.88) was observed Moreover, good relationships of K_m (R² = 1.00) and V_max (R² = 0.98) for P-gp between humans and hMDR1-MAC mice were observed These results suggest that P-gp-mediated DDI and non-linear absorption can be predicted using hMDR1-MAC mice. These mice are a useful in vivo tool for quant. predicting P-gp-mediated disposition in drug discovery and development. This study involved multiple reactions and reactants, such as 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0Category: piperidines).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

New pencil graphite electrodes for potentiometric determination of fexofenadine hydrochloride and montelukast sodium in their pure, synthetic mixtures, and combined dosage form was written by Nashed, Dania;Noureldin, Imad;Sakur, Amir Alhaj. And the article was included in BMC Chemistry in 2020.Quality Control of 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid The following contents are mentioned in the article:

This paper introduces the first electrochem. approach for the determination of Fexofenadine hydrochloride and Montelukast sodium as a combined form by constructing three new graphite electrodes coated with a polymeric membrane. The first electrode was constructed using ammonium molybdate reagent as an ion pair with fexofenadine cation for the determination of Fexofenadine drug, the second electrode was constructed using cobalt nitrate as an ion pair with montelukast anion for the determination of Montelukast drug, the third electrode was prepared by incorporating the two previously mentioned ion pairs in the same graphite sensor, which makes this sensor sensitive to each Fexofenadine and Montelukast drug. The coating material was a polymeric film comprises of Poly Vinyl Chloride (PVC), Di-Bu phthalate as a plasticizer (DBP), ion pairs of drugs with previously mentioned reagents. The electrodes showed a Nernstian response with a mean calibration graph slopes of [59.227, 28.430, (59.048, 28,643)] mv.decade-1 for the three pencil electrodes resp., with detection limits 0.025μM for Fexofenadine and 0.019μM for Montelukast drug which makes this method outperforms the reported method for the determination of this combination. The electrodes work effectively over pH range (2-4.5) for Fexofenadine hydrochloride and (5-9.5) for Montelukast sodium. The influence of the proposed interfering species was negligible as shown by selectivity coefficient values. The effectiveness of the electrodes continued in a period of time (45-69) days. The suggested sensors demonstrated useful anal. features for the determination of both drugs in bulk powder, in laboratory prepared mixtures and their combined dosage form. We have validated the method following ICH protocol, and we have reached very significant results in terms of the linearity, accuracy, selectivity, and precision of the method. This study involved multiple reactions and reactants, such as 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0Quality Control of 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Quality Control of 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Soluble Epoxide Hydrolase Inhibition Attenuates MPTP-Induced Neurotoxicity in the Nigrostriatal Dopaminergic System: Involvement of α-Synuclein Aggregation and ER Stress was written by Huang, Hui-Ju;Wang, Yi-Ting;Lin, Hui-Ching;Lee, Yi-Hsuan;Lin, Anya Maan-Yuh. And the article was included in Molecular Neurobiology in 2018.Application of 1222780-33-7 The following contents are mentioned in the article:

Soluble epoxide hydrolase (sEH) is widely expressed in the mammalian brain and possesses dual enzymic activities, including C-terminal epoxide hydrolase (C-EH) which degrades epoxyeicosatrienoic acid (EET), a beneficial arachidonic acid metabolite. In the present study, the neuroprotective effect of sEH inhibition on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurodegeneration of nigrostriatal dopaminergic system was investigated using genetic and pharmacol. approaches. MPTP (15 mg/kg) was i.p. injected in sEH knockout (KO) mice and C57BL/6J mice as wild-type (WT) mice. Compared with the MPTP-treated WT mice, MPTP-induced reductions in striatal dopamine content and nigral tyrosine hydroxylase level (TH, a biomarker of dopaminergic neurons) were less significant in the treated sEH mice. Furthermore, MPTP-induced HO-1 elevation (a redox-regulated protein), α-synuclein aggregation, and caspase 12 activation (a hallmark of ER stress) were less prominent in sEH KO mice than in WT mice. These data indicate that sEH KO mice are more resistant to MPTP-induced neurotoxicity. The pharmacol. effect of N-[1-(1-oxopropyl)-4-piperidinyl]-N0-[4-(trifluoromethoxy)phenyl]-urea (TPPU, an sEH inhibitor) on MPTP-induced neurotoxicity was investigated in WT mice. TPPU (1 mg/kg, i.p.) attenuated MPTP-induced reduction in striatal dopamine content, TH-pos. cell numbers, TH, and pro-caspase 9 protein levels (an initiator caspase of apoptosis) in mouse SN. Moreover, TPPU reduced MPTP-induced HO-1 elevation, α-synuclein aggregation and caspase 12 activation, indicating that TPPU is effective in attenuating MPTP-induced oxidative stress, apoptosis, protein aggregation, and ER stress. In conclusion, our study suggests that sEH is a potential target for developing therapies for parkinsonism. Furthermore, sEH inhibitors may be of clin. significance for treating CNS neurodegenerative diseases. This study involved multiple reactions and reactants, such as 1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea (cas: 1222780-33-7Application of 1222780-33-7).

1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea (cas: 1222780-33-7) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Application of 1222780-33-7

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

The Role of P-Glycoprotein in Decreasing Cell Membranes Permeability during Oxidative Stress was written by Shchulkin, Alexey V.;Abalenikhina, Yulia V.;Erokhina, Pelageya D.;Chernykh, Ivan V.;Yakusheva, Elena N.. And the article was included in Biochemistry (Moscow) in 2021.Recommanded Product: 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid The following contents are mentioned in the article:

P-Glycoprotein (P-gp) is one of the most clin. significant representatives of the ABC transporter superfamily due to its participation in the transport of biotic components and xenobiotics across the plasma membrane. It is known that various chems., environmental factors, and pathol. processes can affect P-gp activity and expression. In this study, we investigated the role of P-gp in limiting the cell membrane permeability during oxidative stress. Human adenocarcinoma colon cells (Caco-2) overexpressing P-gp were cultured for 72 h in the medium containing hydrogen peroxide (0.1-50μM). The transport of the P-gp substrate fexofenadine was evaluated in a special Transwell system. The amounts of P-gp and Nrf2 transcription factor were analyzed by the ELISA. The concentration of SH-groups in proteins and the contents of lipid peroxidation products and protein carbonyl derivatives were determined spectrophotometrically. Hydrogen peroxide at a concentration of 0.1-5μM did not significantly affect the studied parameters, while incubation with 10μM H2O2 decreased in the level of SH groups in cell lysates and increased in the amount of Nrf2 in the cell lysates. Nrf2, in its turn, mediated an increase in the content and activity of the P-gp transporter, thus limiting the increasing permeability of the cell membrane. Hydrogen peroxide at a concentration of 50μM promoted oxidative stress, which was manifested as a decrease in the content of SH-groups, increase in the concentration of lipid peroxidation products and protein carbonyl derivatives, and decrease in the P-gp level, which led to a significantly increased permeability of the plasma membrane. These results show that the transport and protective roles of P-gp, in particular, reduction of the cell membrane permeability, are affected by the intensity of oxidative stress and can be manifested only if the extent of membrane damage is insignificant. This study involved multiple reactions and reactants, such as 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0Recommanded Product: 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Recommanded Product: 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Prescription pattern of drugs prescribed in out patient department of ENT and adverse drug reactions reported from ENT department in a tertiary care hospital of Bihar was written by Kumari, Nidhi;Mishra, Sarita Kumari;Kumar, Manish;Shakur, Adil Ali;Mishra, Hitesh;Dikshit, Harihar. And the article was included in International Journal of Pharmaceutical Sciences Review and Research in 2022.Category: piperidines The following contents are mentioned in the article:

Diseases related to Ear, Nose & Throat (ENT) occur very commonly in all age groups. Thus periodic evaluation of prescription pattern and adverse drug reaction (ADR) monitoring will be helpful in enabling appropriate modifications in prescribing pattern. This will also result in improved therapeutic efficacy and better patient compliance. The aim of the study is to evaluate prescription pattern of drugs prescribed in ENT OPD and to analyze the ADRs from ENT Department (IPD & OPD). This was an observational & prospective study, conducted for the duration of six months i.e. from March 2021 to Oct. 2021. Prescription was analyzed for demog. details, pattern of prescribed medications, pattern/types of ENT diseases and adequacy of prescription. For monitoring of ADRs active surveillance and spontaneous reporting both were used. In this study, prescription of 251 patients were analyzed. It was found that male patients (64.5%) were significantly higher. A total of 850 drugs were prescribed. The most commonly prescribed group of drugs were antimicrobials. Most commonly prescribed FDC was of cefpodoxime and clavulanic acid. Otitis media was the most commonly suffered condition. Dose, frequency, total duration of treatment and instructions in vernacular language was mentioned in all the prescription. The average number of drugs prescribed was 3.3. A total of four ADRs were reported. This study was a sincere attempt to see the prescribing pattern of drugs prescribed in ENT department and its associated ADRs. Antimicrobials were the most commonly prescribed drugs and it could be attributed to increased occurrence of infections. The adequacy of prescription demonstrates good aspects of prescription writing. Since no prescription had more than five drugs; we can say that polypharmacy was avoided. ADR reporting was very low so it strongly suggests the need to spread awareness among health-care workers and patients for reporting. This study involved multiple reactions and reactants, such as 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0Category: piperidines).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Rapid analysis of 65 pharmaceuticals and 7 personal care products in plasma and whole-body tissue samples of fish using acidic extraction, zirconia-coated silica cleanup, and liquid chromatography-tandem mass spectrometry was written by Tanoue, Rumi;Nozaki, Kazusa;Nomiyama, Kei;Kunisue, Tatsuya;Tanabe, Shinsuke. And the article was included in Journal of Chromatography A in 2020.Recommanded Product: 83799-24-0 The following contents are mentioned in the article:

The presence of pharmaceuticals and personal care products (PPCPs) in aquatic systems has raised concern about their potential adverse effects on aquatic organisms. Considering the fact that the physiol./biol. effects of PPCPs are triggered when their concentrations in the organism exceeds the resp. threshold values, it is important to understand the bioconcentration and toxicokinetics of PPCPs in aquatic organisms. In the present study, we developed a convenient anal. method for the determination of 65 pharmaceuticals and 7 personal care products (log K_ow = 0.14-6.04) in plasma and whole-body tissues of fish. The anal. method consists of ultrasound-assisted extraction in methanol/acetonitrile (1:1, volume/volume,) acidified with acetic acid-ammonium acetate buffer (pH 4), cleanup on a HybridSPE-Phospholipid cartridge (zirconia-coated silica cartridge), and quantification with liquid chromatog.-tandem mass spectrometry (LC-MS/MS). Acceptable accuracy (internal standard-corrected recovery: 70%-120%) and intra- and inter-day precision (coefficient of variation: <15%) were obtained for both plasma and whole-body tissue samples. In addition, low method detection limits were achieved for both plasma (0.0077 to 0.93 ng mL^-1) and whole-body tissue (0.022 to 4.3 ng g ^– 1 wet weight), although the developed method is simple and fast – a batch of 24 samples can be prepared within 6 h, excluding the time for measurement with LC-MS/MS. The developed method was successfully applied to the anal. of PPCPs in plasma and whole-body tissue samples of fish collected in a treated wastewater-dominated stream, for a comprehensive evaluation of their bioconcentration properties. The anal. method developed in the present study is sufficiently accurate, sensitive, and rapid, and thus highly useful for the comprehensive evaluation of PPCP residues in fish and would aid in future exposome and risk assessment. This study involved multiple reactions and reactants, such as 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0Recommanded Product: 83799-24-0).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Recommanded Product: 83799-24-0

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Multi-criteria decision-making techniques associated with (Q)SAR risk assessment for ranking surface water microcontaminants identified using LC-QTOF MS was written by Wielens Becker, Raquel;Alves Jachstet, Leticia;Dallegrave, Alexsandro;Ruiz-Padillo, Alejandro;Zanella, Renato;Sirtori, Carla. And the article was included in Science of the Total Environment in 2021.Reference of 83799-24-0 The following contents are mentioned in the article:

Contaminants of emerging concern (CECs) have been a focus of study for years, with investigations revealing the contamination of different environmental matrixes (surface water, soil, air, and sediment) by diverse classes of microcontaminants. Understanding the contamination profiles requires identification and risk assessment of the microcontaminants. In the present work, anal. was made of the presence of 3250 compounds in 27 samples from the Conceicao River (Rio Grande do Sul State, Brazil), using an SPE-LC-QTOF MS method. In total, 150 microcontaminants (confirmed and suspected) of different classes, especially pesticides and pharmaceuticals, were identified by an initial qual. anal. Subsequently, in silico predictions of eight endpoints, using quant. structure-activity relationship ((Q)SAR) models, were employed to determine the risk of each previously screened microcontaminant. This large amount of (Q)SAR data, frequently with conflicting information in relation to the responses of the different endpoints, makes it difficult to define which microcontaminants should be prioritized for anal. Therefore, in order to rank the identified microcontaminants by risk assessment, two multi-criteria decision-making (MCDM) ranking techniques (ToxPi and TOPSIS), associated with a weighting method, were performed to establish the order of priority for further quant. anal. of the most hazardous microcontaminants. The two rankings were statistically similar, especially for the 20 highest priority microcontaminants. Nonetheless, sensitivity tests carried out for the ToxPi and TOPSIS outputs showed higher performance robustness of TOPSIS, compared to ToxPi. This is the first time that such an approach (screening/(Q)SAR/MCDM methods) has been performed in the context of microcontaminant environmental risk evaluation and demonstrated to be an available strategy to help rank the most concern microcontaminants identified in aqueous environment samples. This study involved multiple reactions and reactants, such as 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0Reference of 83799-24-0).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Reference of 83799-24-0

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem