Day: November 21, 2022

Lefebvre, Carole-Anne published the artcileSynthesis of novel substituted pyrimidine derivatives bearing a sulfamide group and their in vitro cancer growth inhibition activity, COA of Formula: C6H12N2O, the publication is Bioorganic & Medicinal Chemistry Letters (2017), 27(2), 299-302, database is CAplus and MEDLINE.

The synthesis of two series of novel substituted pyrimidine derivatives bearing a sulfamide group have been described and their in vitro cancer growth inhibition activities have been evaluated against three human tumor cell lines (HT-29, M21, and MCF7). In general, growth inhibition activity has been enhanced by the introduction of a bulky substituent on the aromatic ring with the best compound having GI₅₀ < 6 μM for all the human tumor cell lines. The MCF7 selective compounds were evaluated on four addnl. human invasive breast ductal carcinoma cell lines (MDA-MB-231, MDA-MB-468, SKBR3, and T47D) and were selective against T47D cell line in all cases except one, suggesting a potential antiestrogen activity.

Bioorganic & Medicinal Chemistry Letters published new progress about 39546-32-2. 39546-32-2 belongs to piperidines, auxiliary class Piperidine,Amine,Amide, name is Piperidine-4-carboxamide, and the molecular formula is C6H12N2O, COA of Formula: C6H12N2O.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Wallace, Michael D. published the artcileRed Algal Molecules – Synthesis of Methyl Neo-β-carrabioside and Its S-Linked Variant via Two Synthetic Routes: A Late Stage Ring Closure and Using a 3,6-Anhydro-D-galactosyl Donor, SDS of cas: 4972-31-0, the publication is Journal of Organic Chemistry (2020), 85(24), 16182-16195, database is CAplus and MEDLINE.

Me neo-β-carrabioside has been synthesized for the first time, employing either a late stage ring closure to install the required 3,6-anhydro-bridge or a suitable 3,6-anhydro-galactosyl donor to form the unfavored 1,2-cis-equatorial α-linkage. Using the late stage ring closure approach, an S-linked analog of Me neo-β-carrabioside was also realized. These compounds have applications in the identification and characterization of marine bacterial exo-α-3,6-anhydro-D-galactosidases that have specific activity on red algal neo-carrageenan oligosaccharides, such as those found in both family 127 and 129 of the glycoside hydrolases. In addition a biochem. assay using the synthesized Me neo-β-carrabioside and the marine bacterial exo-α-3,6-anhydro-D-galactosidase ZgGH129 demonstrates that the min. substrate unit for the enzyme is neo-β-carrabiose.

Journal of Organic Chemistry published new progress about 4972-31-0. 4972-31-0 belongs to piperidines, auxiliary class Piperidine,Benzene, name is 1-(Phenylsulfinyl)piperidine, and the molecular formula is C24H12, SDS of cas: 4972-31-0.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Cunha, Anna C. published the artcileChemistry and anti-herpes simplex virus type 1 evaluation of 4-substituted-1H-1,2,3-triazole-nitroxyl-linked hybrids, Product Details of C9H17NO, the publication is Molecular Diversity (2021), 25(4), 2035-2043, database is CAplus and MEDLINE.

Abstract: HSV disease is distributed worldwide. Anti-herpesvirus drugs are a problem in clin. settings, particularly in immunocompromised individuals undergoing herpes simplex virus type 1 infection. In this work, 4-substituted-1,2,3-1H-1,2,3-triazole linked nitroxyl radical derived from TEMPOL were synthesized, and their ability to inhibit the in vitro replication of HSV-1 was evaluated. The nitroxide derivatives were characterized by IR spectroscopy and elemental anal., and three of them had their crystal structures determined by single-crystal X-ray diffraction. Four hybrid mols. showed important anti-HSV-1 activity with IC₅₀ values ranged from 0.80 to 1.32μM. In particular, one of the nitroxide derivatives was more active than Acyclovir (IC₅₀ = 0.99μM). All compounds tested were more selective inhibitors than the reference antiviral drug. Among them, two compounds were 4.5 (IC₅₀ 0.80μM; selectivity index CC₅₀/IC₅₀ 3886) and 7.7 times (IC₅₀ 1.10μM; selectivity index CC₅₀/IC₅₀ 6698) more selective than acyclovir (IC₅₀ 0.99μM; selectivity index CC₅₀/IC₅₀: 869). These nitroxide derivatives may be elected as leading compounds due to their antiherpetic activities and good selectivity.

Molecular Diversity published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C9H17NO, Product Details of C9H17NO.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Peng, Chuan published the artcileLow temperature co-pyrolysis of food waste with PVC-derived char: Products distributions, char properties and mechanism of bio-oil upgrading, Recommanded Product: 2,2,6,6-Tetramethylpiperidin-4-one, the publication is Energy (Oxford, United Kingdom) (2021), 119670, database is CAplus.

The main components of municipal solid waste (MSW) include food waste (FW) and polyvinyl chloride (PVC), which present an opportunity to convert energy or value-added products through low-temperature synergetic pyrolysis. In this study, the characteristics of char and bio-oil derived from MSW, FW and PVC feedstocks via pyrolysis at relatively low temperatures (200-300 °C) for 60 min were investigated. The results revealed that the transformation of PVC to HCl gas production started at a temperature of > 200 °C. The oxygenated carbon groups on the char surface were decomposed at elevated reaction temperatures The relative mol. mass of bio-oil derived from FW increased when PVC-derived char was used as a catalyst at 250 °C. In addition, active functional groups and pore structures were formed through synergistic pyrolysis. This work provides information regarding the possible route underlying the network of char and bio-oil production from the synergistic conversion of FW and PVC-derived char.

Energy (Oxford, United Kingdom) published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C9H17NO, Recommanded Product: 2,2,6,6-Tetramethylpiperidin-4-one.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Nematian, Tahereh published the artcileOne-pot conversion of sesame cake to low N-content biodiesel via nano-catalytic supercritical methanol, Name: 2,2,6,6-Tetramethylpiperidin-4-one, the publication is Renewable Energy (2021), 964-973, database is CAplus.

The fatty acid Me esters (FAMEs) and H2 were produced from sesame cake in supercritical mixture of methanol and water using alumina supported CaO and MgO nanoparticles. The fresh and used catalysts were characterized by ICP-OES, BET, XRD, and TEM techniques. The significant influence of catalysts on the gas production was revealed. Further, the highest amounts of H2, CO, and CO₂ was achieved by MgO/ γ-Al₂O₃ with the hydrogen fraction more than 7.6 times, compared with the non-catalytic process. For biodiesel, CaO/ γ-Al₂O₃ showed the best performance where 35.3% of the liquid product was FAMEs, more than 2.3 times relative to the non-catalytic process. In order to reduce the amounts of nitrogenate content in the liquid fuel, an efficient and scalable method implemented with the Soxhlet apparatus and the absorption tube equipped with CO₂ gas flow system. Accordingly, the N-contents of the liquid products were reduced to highest degree of 65.2%, asserting that the reduced amount of the N-content strongly depends on the catalyst during the production process.

Renewable Energy published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C9H17NO, Name: 2,2,6,6-Tetramethylpiperidin-4-one.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Zeng, Zhenxing published the artcileEnergy-transfer-mediated oxygen activation in carbonyl functionalized carbon nitride nanosheets for high-efficient photocatalytic water disinfection and organic pollutants degradation, Product Details of C9H17NO, the publication is Water Research (2020), 115798, database is CAplus and MEDLINE.

Polymeric photocatalysts are promising candidates for water purification, however their catalytic performance are still unsatisfactory due to the fast charge recombination that leads to low reactive oxygen radicals production In this study, a conceptual energy-transfer-mediated photocatalytic oxygen activation system over polymeric carbon nitride without the need of electron-hole separation is proposed, exhibiting remarkable singlet oxygen triggered bacteria inactivation performance as well as organic pollutants degradation By structure and excitonic effect modulation, the oxygen activation process changes from the traditional electron-transfer mechanism to the final energy-transfer pathway, leading to the selective generation of singlet oxygen with high efficiency. The generated singlet oxygen is found to fervently attack the bacteria membrane, creating irreparable pores or holes on the cell membrane for cytoplasmic contents leaking out to accelerate bacteria destruction. The work demonstrated here offers a new photocatalytic oxygen activation pathway for achieving high-efficient reactive oxygen species generation performance without the need of charge separation

Water Research published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C9H9ClN2, Product Details of C9H17NO.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Padungros, Panuwat published the artcileSynthesis and Reactivity of 4′-Deoxypentenosyl Disaccharides, Formula: C11H15NOS, the publication is Journal of Organic Chemistry (2014), 79(11), 4878-4891, database is CAplus and MEDLINE.

4-Deoxypentenosides (4-DPs) are versatile synthons for rare or higher-order pyranosides, and they provide an entry for structural diversification at the C5 position. Previous studies have shown that 4-DPs undergo stereocontrolled DMDO oxidation; subsequent epoxide ring-openings with various nucleophiles can proceed with both anti or syn selectivity. Here, we report the synthesis of α- and β-linked 4′-deoxypentenosyl (4′-DP) disaccharides, and we investigate their post-glycosylation C₅‘ additions using the DMDO oxidation/ring-opening sequence. The α-linked 4’-DP disaccharides were synthesized by coupling thiophenyl 4-DP donors with glycosyl acceptors using BSP/Tf₂O activation, whereas β-linked 4′-DP disaccharides were generated by the decarboxylative elimination of glucuronyl disaccharides under microwave conditions. Both α- and β-linked 4′-DP disaccharides could be epoxidized with high stereoselectivity using DMDO. In some cases, the α-epoxypentenosides could be successfully converted into terminal L-iduronic acids via the syn addition of 2-furyl-zinc bromide. These studies support a novel approach to oligosaccharide synthesis, in which the stereochem. configuration of the terminal 4′-DP unit is established at a post-glycosylation stage.

Journal of Organic Chemistry published new progress about 4972-31-0. 4972-31-0 belongs to piperidines, auxiliary class Piperidine,Benzene, name is 1-(Phenylsulfinyl)piperidine, and the molecular formula is C11H15NOS, Formula: C11H15NOS.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Shen, Zhuo published the artcileFe-based carbonitride as Fenton-like catalyst for the elimination of organic contaminants, Formula: C9H17NO, the publication is Environmental Research (2021), 110486, database is CAplus and MEDLINE.

The Fenton-like process has been regarded as a clean and efficient approach to generate reactive oxygen species (ROS) to deal with the ever-growing environmental pollution. However, developing improved catalysts with adequate activity and stability remains a long-term goal for practical application. Herein, crystalline carbon nanotubes (CNTs) interconnected Fe/Fe₃C-doped nanoporous carbonitride (Fe-NC) was easily prepared by the pyrolysis of ZIF-8 confined with Fe³⁺. The obtained Fe-NCs possessed high degrees of graphitic carbon and nitrogen. Such Fe-NCs can enhance the activation of peroxymonosulfate (PMS) for the removal of multiple organic contaminants. The optimized Fe-NC/PMS system exhibited impressive catalytic performance, with a TOF as high as 4.43 min^-1 for 3BF degradation, and the removal efficiency of other dyes, phenols and antibiotics was up to 96.2% within 10 min. The removal efficiency of 3BF was 93.4% within 10 min with extremely low Fe ions leaching (<0.052 mg/L) even after 5 cycles. In addition, the effects of pH on the catalytic performance demonstrated that the decomposition of 3BF exceeded 95.6% even when the initial pH varied from 5 to 10. We confirmed that SO₄·^–, ·OH, O₂·^–,and ¹O₂ ere generated in the catalytic system of Fe-NC/PMS, which played a critical role in degrading the organics These findings provide new insights into the design of environmentally friendly Fenton-like catalysts with high efficiency and favorable stability in environmental remediation.

Environmental Research published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C44H28ClFeN4, Formula: C9H17NO.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Hu, Bo published the artcileFive-Membered Ring Nitroxide Radical: A New Class of High-Potential, Stable Catholyte for Neutral Aqueous Organic Redox Flow Batteries, COA of Formula: C9H17NO, the publication is Advanced Functional Materials (2021), 31(35), 2102734, database is CAplus.

The utilization of redox-active and stable cyclic nitroxide radicals (CNRs) holds a great promise in neutral aqueous organic redox flow batteries (AORFBs) for large-scale energy storage. Herein, a new class of CNRs with five-membered ring pyrrolidine and pyrroline motifs for AORFBs is reported. By rational mol. engineering of introducing CC double bond into the pyrrolidine-based mol., 3-carbamoyl-2,2,5,5-tetramethylpyrroline-1-oxyl (CPL) with a high redox potential of 0.76 V (vs Ag/AgCl) is demonstrated, which is 160 mV higher than the common 2,2,6,6-tetramethylpiperidine 1-oxyl derivatives with a six-membered ring as the core structure. D. functional theory calculations reveal that the much enhanced redox potential for CPL is largely contributed by lowered standard free energy in reduction reaction and charge population sum of NO radical head. When paired with the BTMAP-viologen anolyte, the CPL-based AORFB delivers constant capacity retention of up to 99.96%/cycle over 500 cycles.

Advanced Functional Materials published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C9H17NO, COA of Formula: C9H17NO.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Chayajarus, Kampanart published the artcileEfficient synthesis of carbohydrate thionolactones, SDS of cas: 4972-31-0, the publication is Tetrahedron Letters (2006), 47(21), 3517-3520, database is CAplus.

Carbohydrate thionolactones, e.g. I, may be efficiently synthesized from the corresponding 1-thio sugars via a two-step procedure involving formation of a glycosyl phenylthiosulfinate by treatment with either phenylsulfinyl chloride or 1-(phenylsulfinyl)piperidine (BSP), and subsequent thermal elimination in toluene.

Tetrahedron Letters published new progress about 4972-31-0. 4972-31-0 belongs to piperidines, auxiliary class Piperidine,Benzene, name is 1-(Phenylsulfinyl)piperidine, and the molecular formula is C11H15NOS, SDS of cas: 4972-31-0.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem