Day: November 21, 2022

Puckett, James W. published the artcileMicrowave Assisted Synthesis of Py-Im Polyamides, Recommanded Product: 1-((9H-Fluoren-9-yl)methyl)piperidine, the publication is Organic Letters (2012), 14(11), 2774-2777, database is CAplus and MEDLINE.

Microwave synthesis was utilized to rapidly build Py-Im polyamides in high yields and purity using Boc-protection chem. on Kaiser oxime resin. A representative polyamide targeting the 5′-WGWWCW-3′ (W = A or T) subset of the consensus Androgen and Glucocorticoid Response Elements was synthesized in 56% yield after 20 linear steps and HPLC purification It was confirmed by Mosher amide derivatization of the polyamide that a chiral α-amino acid does not racemize after several addnl. coupling steps.

Organic Letters published new progress about 35661-58-6. 35661-58-6 belongs to piperidines, auxiliary class Piperidine,Benzene, name is 1-((9H-Fluoren-9-yl)methyl)piperidine, and the molecular formula is C19H21N, Recommanded Product: 1-((9H-Fluoren-9-yl)methyl)piperidine.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Dmitriev, L. B. published the artcileDemyanov reaction with 1-methyl-3-aminomethylpiperidine, Safety of (1-Methylpiperidin-3-yl)methanamine, the publication is Izvestiya Timiryazevskoi Sel’skokhozyaistvennoi Akademii (1968), 195-200, database is CAplus.

A solution of 5.1 g. 1-methyl-3-aminomethylpiperidine in 50 ml. H2O was neutralized with 10% H3PO4 to pH 5.5 and a solution of 4.2 g. NaNo2 in 50 ml. H2O added dropwise at 0-5°, the mixture kept 2 hrs. at 0-5° and overnight at room temperature, heated at 70° until all gas bubbles were eliminated, and worked up to give 8% Demyanov rearrangement products I-IV, but mainly V-IX. The influence of various temperatures and pH values on the direction of the reaction was not significant.

Izvestiya Timiryazevskoi Sel’skokhozyaistvennoi Akademii published new progress about 14613-37-7. 14613-37-7 belongs to piperidines, auxiliary class Piperidine,Amine, name is (1-Methylpiperidin-3-yl)methanamine, and the molecular formula is C7H16N2, Safety of (1-Methylpiperidin-3-yl)methanamine.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Kumar, Adarsh published the artcileBiocarbon Supported Nanoscale Ruthenium Oxide-Based Catalyst for Clean Hydrogenation of Arenes and Heteroarenes, Product Details of C6H12N2O, the publication is ACS Sustainable Chemistry & Engineering (2020), 8(41), 15740-15754, database is CAplus.

Despite considerable achievements in the hydrogenation of aromatic hydrocarbons over the past few years, the ability to hydrogenate arene or heteroarene rings in a highly selective manner in the presence of other reducible sites or without harming the remaining mol. structure has long been a major challenge. Such chemoselectivity and functional group tolerance is highly desirable for enabling direct access to key building blocks of polymers and pharmaceutical agents. For achieving such high selectivity, the development of suitable catalysts is of central importance. Herein, we report a convenient method for the scalable preparation of ruthenium oxide (RuO₂) nanoparticles supported on pine needle char (PNC) by simple impregnation of ruthenium salt on unactivated PNC, a solid byproduct (biochar) obtained in the slow pyrolysis of biomass pine needles. The resulting RuO₂-based nanocatalyst (RuO₂@PNC) exhibited remarkable activity and high selectivity for the hydrogenation of more than 50 challenging arenes and heteroarenes, including biomass-derived aromatic compounds (e.g., 4-n-propylphenol, furfuryl alc., and 2-Me furan). The synthetic value of this transformation is showcased for the hydrogenation of arene mixture present in petroleum refineries or coal tars as well as biomass-derived oils (bio-oils) with enriched furfural, ether, and phenol derivatives Under optimized conditions, the performance of this new catalyst was compared with state-of-the-art com. catalysts such as Ru/C, Pd/C, and Raney nickel and found that RuO₂@PNC is more superior and selective. Furthermore, the catalyst is easily recovered and reused up to four cycles. Biocarbon supported RuO₂-based catalyst exhibited remarkable activity and selectivity for clean hydrogenation of arenes and heteroarenes.

ACS Sustainable Chemistry & Engineering published new progress about 39546-32-2. 39546-32-2 belongs to piperidines, auxiliary class Piperidine,Amine,Amide, name is Piperidine-4-carboxamide, and the molecular formula is C6H12N2O, Product Details of C6H12N2O.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Williams, Noelle S. published the artcileTumor-Activated Benzothiazole Inhibitors of Stearoyl-CoA Desaturase, Quality Control of 1032229-33-6, the publication is Journal of Medicinal Chemistry (2020), 63(17), 9773-9786, database is CAplus and MEDLINE.

A series of N-acyl benzothiazoles shows selective and potent cytotoxicity against cancer cell lines expressing cytochrome P 450 4F11. A prodrug form is metabolized by cancer cells into an active inhibitor of stearoyl-CoA desaturase (SCD). Substantial variation on the acyl portion of the inhibitors allowed the identification of (R)-27, which balanced potency, solubility, and lipophilicity to allow proof-of-concept studies in mice. The prodrugs were activated inside the tumor, where they can arrest tumor growth. Together, these observations offer promise that a tumor-activated prodrug strategy might exploit the essentiality of SCD for tumor growth, while avoiding toxicity associated with systemic SCD inhibition.

Journal of Medicinal Chemistry published new progress about 1032229-33-6. 1032229-33-6 belongs to piperidines, auxiliary class Metabolic Enzyme,SCD, name is 4-(2-Chlorophenoxy)-N-(3-(methylcarbamoyl)phenyl)piperidine-1-carboxamide, and the molecular formula is C30H42NOP, Quality Control of 1032229-33-6.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Faul, Margaret M. published the artcileAcyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCβ, Product Details of C18H24N2O2, the publication is Bioorganic & Medicinal Chemistry Letters (2003), 13(11), 1857-1859, database is CAplus and MEDLINE.

The synthesis and structure-activity relationship (SAR) trends of a new class of N-(azacycloalkyl)bisindolylmaleimides, e.g. I (R¹ = CH₂-pyridyl, R² = Me, n = 2), acyclic derivatives of staurosporine, is described. I exhibits an IC₅₀ of 40-50 nM against the human PKCβ₁ and PKCβ₂ isoenzymes and selectively inhibits the PKCβ isoenzymes in comparison to other PKC isoenzymes (α, γ, δ, ε, λ, and η). The series is also kinase selective for PKC in comparison to other ATP-dependent kinases. A comparison of the protein kinase C (PKC) isoenzyme and kinase activity of the series is made to the kinase inhibitor staurosporine.

Bioorganic & Medicinal Chemistry Letters published new progress about 170364-89-3. 170364-89-3 belongs to piperidines, auxiliary class Indole,Piperidine,Amide, name is tert-Butyl 4-(1H-indol-1-yl)piperidine-1-carboxylate, and the molecular formula is C18H24N2O2, Product Details of C18H24N2O2.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Fidecka, Katarzyna published the artcileQuantification of amino groups on halloysite surfaces using the Fmoc-method, Category: piperidines, the publication is RSC Advances (2020), 10(24), 13944-13948, database is CAplus and MEDLINE.

The functionalization of halloysite nanotube (HNT) surfaces with aminosilanes is an important strategy for their further decoration with organic mols. to obtain hybrid inorganic-organic nanoarchitectures to be used in catalysis and drug delivery. The exact quantification of amino groups on the surface is an important aspect in view of the obtainment of systems with a known number of loaded mols. In the present study, we describe a simple and reliable method for the correct quantification of groups present on HNT surfaces after their reaction with aminopropyltriethoxysilane (APTES). This method, applied for the first time to HNT chem., was based on the use of Fmoc groups as probes covalently bound to APTES and quantified by UV-Vis after release from the HNT-APTES-Fmoc system. Interestingly, this method showed great accordance with the already employed quant. thermogravimetric anal. (TGA), with some benefits such as simple and non-destructive procedure, besides the possibility to monitor the deprotection reaction.

RSC Advances published new progress about 35661-58-6. 35661-58-6 belongs to piperidines, auxiliary class Piperidine,Benzene, name is 1-((9H-Fluoren-9-yl)methyl)piperidine, and the molecular formula is C19H21N, Category: piperidines.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Mukherjee, Mana Mohan published the artcileSynthetic Routes toward Acidic Pentasaccharide Related to the O-Antigen of E. coli 120 Using One-Pot Sequential Glycosylation Reactions, Recommanded Product: 1-(Phenylsulfinyl)piperidine, the publication is Journal of Organic Chemistry (2017), 82(11), 5751-5760, database is CAplus and MEDLINE.

Concise syntheses of the acidic pentasaccharide, related to the O-antigenic polysaccharide of Escherichia coli 120, as its p-methoxyphenyl glycoside, have been achieved using a one-pot sequential glycosylation technique. The glycosylation have been accomplished either by the activation of the thioglycosides using NIS in the presence of FeCl₃ or by a pre-activation by Ph₂SO, TTBP, Tf₂O, and the activation of the trichloroacetimidates using FeCl₃ alone or TMSOTf. Most of the intermediate steps are high yielding, and the stereo outcomes of the glycosylation steps were excellent. The syntheses of the targeted pentasaccharide have been performed with both three- and four-component, one-pot sequential glycosylation reactions, and in both cases, the orthogonal glycosylation is carried out utilizing catalytic activity of FeCl₃. A late-stage TEMPO-mediated regioselective oxidation has been performed to achieve the required uronic acid motif.

Journal of Organic Chemistry published new progress about 4972-31-0. 4972-31-0 belongs to piperidines, auxiliary class Piperidine,Benzene, name is 1-(Phenylsulfinyl)piperidine, and the molecular formula is C11H15NOS, Recommanded Product: 1-(Phenylsulfinyl)piperidine.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Ullrich, Thomas published the artcileSynthesis and immobilization of erythro-C14-ω-aminosphingosine-1-phosphate as a potential tool for affinity chromatography, Recommanded Product: 1-((9H-Fluoren-9-yl)methyl)piperidine, the publication is ChemMedChem (2008), 3(2), 356-360, database is CAplus and MEDLINE.

A sphingosine-1-phosphate (S1P) analog containing a terminal alkyl chain amino group is synthesized in a few steps via olefin cross-metathesis of an optically resolved intermediate and subsequent phosphorylation. Regioselective acylation of this intermediate at its N terminus in solution is demonstrated as a model reaction and provides a biol. active derivative Finally, the ω-amino intermediate is immobilized on an affinity matrix. The choice of a UV-active phosphate protecting group allows for quantification of resin loading after cleavage which amounted to 66%.

ChemMedChem published new progress about 35661-58-6. 35661-58-6 belongs to piperidines, auxiliary class Piperidine,Benzene, name is 1-((9H-Fluoren-9-yl)methyl)piperidine, and the molecular formula is C13H22BN3O4, Recommanded Product: 1-((9H-Fluoren-9-yl)methyl)piperidine.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Haake, M. published the artcileDialkylaminosuccinimidosulfonium compounds. 3. A simple method for the oxidation of sulfenamides to sulfinamides, Safety of 1-(Phenylsulfinyl)piperidine, the publication is Synthesis (1979), 97, database is CAplus.

R¹SNR₂ were oxidized by treatment with N-chlorosuccinimide in CH₂Cl₂ to give a succinimidosulfonium chloride intermediate which was hydrolyzed in situ by aqueous KHCO₃ to give 41-85% R¹SONR₂ [R₂ = Me₂, (CH₂)₅, or (CH₂)₂O(CH₂)₂; R¹ = Et or Ph].

Synthesis published new progress about 4972-31-0. 4972-31-0 belongs to piperidines, auxiliary class Piperidine,Benzene, name is 1-(Phenylsulfinyl)piperidine, and the molecular formula is C11H15NOS, Safety of 1-(Phenylsulfinyl)piperidine.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Wang, Gen published the artcileActivation of peroxydisulfate by defect-rich CuO nanoparticles supported on layered MgO for organic pollutants degradation: An electron transfer mechanism, Quality Control of 826-36-8, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2022), 431(Part_1), 134026, database is CAplus.

Heterogeneous activation of peroxydisulfate (PDS) by transition metal oxides offers a promising strategy for organic pollutants removal but suffers from low electron transfer efficiency. Herein, layered MgO supported CuO nanoparticles was prepared by thermal conversion of metal-phenolic networks of Cu²⁺/Mg²⁺ and tannic acid. CuO nanoparticles (â‰? nm) were spatial monodispersed on layered MgO, inducing the formation of electron deficient Cu³⁺ and surface oxygen vacancies and thus facilitated adsorption and activation of PDS. The electron-rich CuO/MgO hybrid catalysts manifested good catalytic performance of PDS activation for organic pollutants removal. At 0.18 g/L of CuO/MgO hybrid catalyst and 0.2 mM of PDS, complete removal of bisphenol A (BPA) was achieved with a high kinetic constant (0.1 min^-1, 50 min). Quenching experiments, ESR tests, PDS decomposition behaviors, electrochem. anal. and in situ ATR-FTIR and Raman spectroscopy revealed a nonradical pathway of electron transfer for PDS activation. The CuO/MgO hybrid catalysts exhibited wide working pH range from 3 to 11, selective oxidation capability, good resistance to halide ion and high utilization efficiency of PDS, and thus would be a promising candidate for wastewater remediation.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C5H5ClIN, Quality Control of 826-36-8.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem