Day: November 21, 2022

Vastyl, Michal published the artcileA case study on microwave pyrolysis of waste tyres and cocoa pod husk; effect on quantity and quality of utilizable products, HPLC of Formula: 826-36-8, the publication is Journal of Environmental Chemical Engineering (2022), 10(1), 106917, database is CAplus.

Disposal of huge amounts of diverse wastes for reduced costs accompanied with gaining of energy and valuable chems. is an eager topic in waste-to-energy and fuel business. Microwave pyrolysis is a thermochem. route providing such benefits. Waste scrap tyres (ST) and cocoa pod husk (CPH) as polymer and biomass representatives were pyrolyzed in microwave reactor at 440 W power for 30 min. Quantity and quality of pyrolysis products (gas, oil, and carbon black) were investigated. It was revealed, while set microwave pyrolysis conditions are sufficient for maximum decomposition of ST to pyrolysis products, it is necessary to optimize them for CPH. The gas produced by microwave pyrolysis of ST contains more H2 and CH4 than from conventional pyrolysis, thus, microwave pyrolysis is an effective tool for production of a fuel gas. The oil obtained by ST microwave pyrolysis is a complex mixture of mostly nonpolar aromatic compounds (toluene, benzene, limonene, styrene, o-xylene), while the oil obtained by CPH microwave pyrolysis contains mainly p-cresol, phenol and its derivatives The ST-derived carbon black shows a well-established large-volume mesoporous-macroporous structure. The CPH-derived carbon black is a low-volume macroporous material with very well-developed microporosity. A higher gross calorific value of microwave ST-derived carbon black in comparison to conventionally prepared one is caused by its higher graphitization rate. Since the surface of ST-derived carbon black is more polar than CPH-derived one and with respect to chem. purity, it could be more suitable adsorbent for polar volatile organic compounds from gaseous emissions. It is necessary to develop a microporosity in ST-derived carbon black.

Journal of Environmental Chemical Engineering published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C11H9ClN2O, HPLC of Formula: 826-36-8.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Ma, Winson M. J. published the artcileSynthesis of Amines with Pendant Boronic Esters by Borrowing Hydrogen Catalysis, Application of 1-(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperidine, the publication is Organic Letters (2013), 15(18), 4850-4853, database is CAplus and MEDLINE.

Amine alkylation reactions of alcs. were performed in the presence of boronic ester groups to provide products which are known for their use as mol. sensors. E.g., reaction of (4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol with morpholine in the presence of 2.5 mol% [Ru(p-cymene)Cl₂]₂ and 5 mol% DPEphos ligand in xylene/Na₂CO₃ at 155° to give (4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)morpholine in 84% yield. The boronic ester moiety could be present in either the alc. or amine starting material and was not compromised in the presence of a Ru catalyst.

Organic Letters published new progress about 859833-21-9. 859833-21-9 belongs to piperidines, auxiliary class Piperidine,Boronic acid and ester,Benzene,Boronic Acids,Boronate Esters, name is 1-(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperidine, and the molecular formula is C18H28BNO2, Application of 1-(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperidine.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Robles, Omar published the artcileNovel Piperidinyl-Azetidines as Potent and Selective CCR4 Antagonists Elicit Antitumor Response as a Single Agent and in Combination with Checkpoint Inhibitors, HPLC of Formula: 1251006-73-1, the publication is Journal of Medicinal Chemistry (2020), 63(15), 8584-8607, database is CAplus and MEDLINE.

The C-C chemokine receptor 4 (CCR4) is broadly expressed on regulatory T cells (T_reg) as well as other circulating and tissue-resident T cells. T_reg can be recruited to the tumor microenvironment (TME) through the C-C chemokines CCL17 and CCL22. T_reg accumulation in the TME has been shown to dampen the antitumor immune response and is thought to be an important driver in tumor immune evasion. Preclin. and clin. data suggest that reducing the T_reg population in the TME can potentiate the antitumor immune response of checkpoint inhibitors. We have developed small-mol. antagonists of CCR4, featuring a novel piperidinyl-azetidine motif, that inhibit the recruitment of T_reg into the TME and elicit antitumor responses as a single agent or in combination with an immune checkpoint blockade. The discovery of these potent, selective, and orally bioavailable CCR4 antagonists(I), and their activity in in vitro and in vivo models, is described herein.

Journal of Medicinal Chemistry published new progress about 1251006-73-1. 1251006-73-1 belongs to piperidines, auxiliary class Azetidine,Piperidine,Amide, name is tert-Butyl 3-(piperidin-3-yl)azetidine-1-carboxylate, and the molecular formula is C13H24N2O2, HPLC of Formula: 1251006-73-1.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Ohira, Kazuki published the artcileDevelopment of phenazine-2,3-diol-based photosensitizers: effect of formyl groups on singlet oxygen generation, Quality Control of 826-36-8, the publication is Materials Chemistry Frontiers (2021), 5(14), 5298-5304, database is CAplus.

Phenazine-2,3-diol derivatives KO-0-3, which have zero to three formyl groups, resp., have been developed as photosensitizers (PSs) possessing the ability to generate singlet oxygen (1O2). The photoabsorption bands of KO-0-3 are significantly red-shifted compared to those of phenazine-2,3-MOM (methoxymethyl) derivatives 5-8, whose hydroxy and formyl groups are protected, and have onsets at around 600-650 nm. Furthermore, the fluorescence quantum yields (Φfl) of KO-0-3 (Φfl = 0.024-0.097) are lower than those of 5-8 (Φfl = 0.34-0.46) in solution To gain insight into the 1O2 generation properties of KO-0-3, we evaluated the 1O2 quantum yields (ΦΔ) and rate constants (kobs), and demonstrated that KO-1-3 possess a higher ability to generate 1O2 under visible light irradiation than those of 5-8. Moreover, it was found that the ΦΔ values of KO-0-3 increase in the order of KO-0 (0.036) < KO-1 (0.22) < KO-2 (0.33) < KO-3 (0.41) with increasing number of formyl groups. This result indicates that formyl groups facilitate the intersystem crossing (ISC) from the lowest singlet excited states of the PSs (S1) to the triplet excited states (Tn) according to El-Sayed′s rule. Consequently, this work provides useful knowledge in mol. design of efficient phenazine-2,3-diol-based PSs for photodynamic therapy (PDT).

Materials Chemistry Frontiers published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C9H17NO, Quality Control of 826-36-8.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Mizukawa, Yuki published the artcileQuest for a potent antimalarial drug lead: Synthesis and evaluation of 6,7-dimethoxyquinazoline-2,4-diamines, Safety of Piperidine-4-carboxamide, the publication is Bioorganic & Medicinal Chemistry (2021), 116018, database is CAplus and MEDLINE.

Quinazolines have long been known to exert varied pharmacol. activities that make them suitable for use in treating hypertension, viral infections, tumors, and malaria. Since 2014, author’s have synthesized approx. 150 different 6,7-dimethoxyquinazoline-2,4-diamines and evaluated their antimalarial activity via structure-activity relationship studies. Here, author’s summarize the results and report the discovery of 6,7-dimethoxy-N4-(1-phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-amine, which exhibits high antimalarial activity as a promising antimalarial drug lead.

Bioorganic & Medicinal Chemistry published new progress about 39546-32-2. 39546-32-2 belongs to piperidines, auxiliary class Piperidine,Amine,Amide, name is Piperidine-4-carboxamide, and the molecular formula is C6H12N2O, Safety of Piperidine-4-carboxamide.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Nemec, Vaclav published the artcileFuro[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway, Recommanded Product: (3-(Piperidin-1-yl)phenyl)boronic acid, the publication is Angewandte Chemie, International Edition (2019), 58(4), 1062-1066, database is CAplus and MEDLINE.

Reported is the identification of the furo[3,2-b]pyridine core as a novel scaffold for potent and highly selective inhibitors of cdc-like kinases (CLKs) and efficient modulators of the Hedgehog signaling pathway. Initially, a diverse target compound set was prepared by synthetic sequences based on chemoselective metal-mediated couplings, including assembly of the furo[3,2-b]pyridine scaffold by copper-mediated oxidative cyclization. Optimization of the subseries containing 3,5-disubstituted furo[3,2-b]pyridines, e.g. I, afforded potent, cell-active, and highly selective inhibitors of CLKs. Profiling of the kinase-inactive subset of 3,5,7-trisubstituted furo[3,2-b]pyridines, e.g. II, revealed sub-micromolar modulators of the Hedgehog pathway.

Angewandte Chemie, International Edition published new progress about 634905-21-8. 634905-21-8 belongs to piperidines, auxiliary class Piperidine,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is (3-(Piperidin-1-yl)phenyl)boronic acid, and the molecular formula is C11H16BNO2, Recommanded Product: (3-(Piperidin-1-yl)phenyl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Dennis, William H. Jr. published the artcileOxidations of amines. IV. Oxidative fragmentation, Product Details of C7H15NO, the publication is Journal of Organic Chemistry (1967), 32(12), 3783-7, database is CAplus.

Oxidation of a representative group of β-amino and β-hydroxy amines with either ClO2 or NaClO resulted in C-C cleavage to give HCHO along with NH3 or the corresponding primary or secondary amine. The relationship of this reaction to the fragmentation reactions described by Brenneisen, et al. (CA 62: 11769a) suggested the term “oxidative fragmentation.” 24 references.

Journal of Organic Chemistry published new progress about 13444-24-1. 13444-24-1 belongs to piperidines, auxiliary class Piperidine,Alcohol, name is 1-Ethylpiperidin-3-ol, and the molecular formula is C7H15NO, Product Details of C7H15NO.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Shen, Minxian published the artcileActivation of persulfate for tetracycline degradation using the catalyst regenerated from Fenton sludge containing heavy metal: Synergistic effect of Cu for catalysis, Formula: C9H17NO, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2020), 125238, database is CAplus.

Fenton reaction is widely used as a unique oxidation method for industrial wastewater treatment; however, it generates a massive amount of Fe sludge, which mostly contains other hazardous heavy metal wastes which can harm the environment and humans. This work proposed a sustainable method to eliminate side effects of the Fenton reaction and to transform Cu-containing Fenton sludge into an efficient catalyst for peroxymonosulfate (PMS) activation for tetracycline (TC) degradation The existence of Cu, which can increase sludge O₂ vacancies, was attributed to the activation efficiency compared to Fe sludge with no Cu. X-ray diffraction and XPS results showed Fe is present as α-Fe₂O₃ and γ-Fe₂O₃; Cu mostly exists as Cu²⁺. Catalyst and PMS doses, pH, and recycling time effect on PMS reaction was illustrated. OH^–, SO₄^– O₂^–, and ¹O₂ were the critical reactive oxygen species. TC decomposes into CO₂ and water through six possible pathway processes with these free radicals. Given its sustainable treatment and high catalytic efficiency, dealing with Fe sludge which contains heavy metals serves as a modal practice for harmful wastewater treatment and can be popularized for broader applications.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C3H5F3O, Formula: C9H17NO.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Long, Yangke published the artcilePeroxymonosulfate activation for pollutants degradation by Fe-N-codoped carbonaceous catalyst: Structure-dependent performance and mechanism insight, Related Products of piperidines, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2019), 542-552, database is CAplus.

In this study, Fe-N-codoped carbonaceous catalysts (Fe-N-C-x) with different structures including one-dimensional carbon nanotubes (1D CNTs) and two-dimensional porous carbon sheets (2D NC) to three-dimensional carbon nanotubes/porous carbon sheets composites (3D CNTs/NC) were systematically synthesized and applied as peroxymonosulfate (PMS) activators. It was found that the Fe-N-C-x catalysts exhibited structure-dependent catalytic performance, following the order of 2D NC > 3D CNTs/NC > 1D CNTs, and also substrate-dependent degradation performance that the reaction kinetics varied greatly for different organic pollutants. Benefiting from the unique structure characteristic and high d. of active sites, 2D Fe-N-C-1 showed far superior catalytic performance than the generally used carbocatalysts with negligible Fe leaching. Besides, various influential factors affecting the catalytic performance were systematically investigated. Fe-N-C-1 showed high catalytic efficiencies toward a broad spectrum of organic pollutants, and it was confirmed that both radical and non-radical degradation pathways existed during pollutants degradation The competitive radical quenching tests and ESR measurements verified that the superoxide anion radical (O^A·-₂) was the primary reactive oxidized species for degradation of p-chlorophenol (4-CP). The chronoamperometry anal. demonstrated that Fe-N-C-1 facilitated the electron transfer from 4-CP to PMS, resulting in the degradation of 4-CP through a non-radical mechanism. Our result not only reveals the structure-dependent PMS activation performance of transition-metal and nitrogen codoped carbocatalysts but also provides solid evidence that the defect-rich carbon materials with amorphous carbon and partial graphitic structure also favor the electron transfer mechanism.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C9H17NO, Related Products of piperidines.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Ochiai, Hirofumi published the artcileExpeditious Chemoenzymatic Synthesis of Homogeneous N-Glycoproteins Carrying Defined Oligosaccharide Ligands, Synthetic Route of 4972-31-0, the publication is Journal of the American Chemical Society (2008), 130(41), 13790-13803, database is CAplus and MEDLINE.

An efficient chemoenzymic method for the construction of homogeneous N-glycoproteins was described that explores the transglycosylation activity of the endo-β-N-acetylglucosaminidase from Arthrobacter protophormiae (Endo-A) with synthetic sugar oxazolines as the donor substrates. First, an array of large oligosaccharide oxazolines were synthesized and evaluated as substrates for the Endo-A-catalyzed transglycosylation by use of RNase B as a model system. The exptl. results showed that Endo-A could tolerate modifications at the outer mannose residues of the Man₃GlcNAc-oxazoline core, thus allowing introduction of large oligosaccharide ligands into a protein and meanwhile preserving the natural, core N-pentasaccharide (Man₃GlcNAc₂) structure in the resulting glycoprotein upon transglycosylation. In addition to ligands for galectins and mannose-binding lectins, azido functionality could be readily introduced at the N-pentasaccharide (Man₃GlcNAc₂) core by use of azido-containing Man₃GlcNAc oxazoline as the donor substrate. The introduction of azido functionality permits further site-specific modifications of the resulting glycoproteins, as demonstrated by the successful attachment of two copies of αGal epitopes to RNase B. This study reveals a broad substrate specificity of Endo-A for transglycosylation, and the chemoenzymic method described here points to a new avenue for quick access to various homogeneous N-glycoproteins for structure-activity relationship studies and for biomedical applications.

Journal of the American Chemical Society published new progress about 4972-31-0. 4972-31-0 belongs to piperidines, auxiliary class Piperidine,Benzene, name is 1-(Phenylsulfinyl)piperidine, and the molecular formula is C11H15NOS, Synthetic Route of 4972-31-0.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem