Day: November 18, 2022

Sharma, Pankaj published the artcileOne-Pot Synthesis of Substituted Piperidinones and 3,4-Dihydropyrimidinones Using a Highly Active and Recyclable Supported Ionic Liquid Phase Organocatalyst, Product Details of C6H11NO, the main research area is piperidinone dihydropyrimidinone preparation silica supported ionic liquid organocatalyst.

1-Ethyl-3-methylimidazolium Et sulfate was synthesized and its supported ionic liquid phase form was prepared and used as an organocatalyst for the synthesis of substituted piperidinones and 3,4-dihydropyrimidinones. The ionic liquid was characterized by 1H NMR, 13C NMR, and mass spectrometry. The catalyst is novel, stable, completely heterogeneous, and recyclable for several times and can be easily recovered by filtration. It was characterized with SEM, TEM, TGA, and energy-dispersive x-ray spectroscopy techniques. The workup procedures are very simple, and products were obtained in good-to-excellent yields with reasonable purities without the need for further chromatog. purification

Australian Journal of Chemistry published new progress about Ionic liquids. 5773-58-0 belongs to class piperidines, name is 3-Methylpiperidin-4-one, and the molecular formula is C6H11NO, Product Details of C6H11NO.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Zhang, Xi published the artcileCooperative influences of nanoparticle localization and phase coarsening on thermal conductivity of polypropylene/polyolefin elastomer blends, Recommanded Product: Bis(2,2,6,6-tetramethylpiperidin-4-yl) decanedioate, the main research area is polypropylene polyolefin rubber alumina nanocomposite morphol thermal conductivity.

Polypropylene (PP)/polyolefin elastomer (POE)/aluminum oxide (Al2O3) nanocomposites were prepared based on a reactor granule technol. (RGT). The effect of nanoparticle migration and phase morphol. evolution on the formation of thermal conductive networks was systematically studied. The utilization of RGT and POE with high viscosity enabled successful migration of in-situ generated Al2O3 nanoparticles at the interface of PP and POE, as combined results of uniform dispersion of Al2O3 and accompanied small phase domain size of PP [1]. The localization of the nanoparticles at the interface also contributed to suppression of the phase coarsening during annealing. The nanoparticle migration to the interface and the retarded phase coarsening synergistically contributed to the enhanced thermal conductivity

Composites, Part A: Applied Science and Manufacturing published new progress about Heat capacity. 52829-07-9 belongs to class piperidines, name is Bis(2,2,6,6-tetramethylpiperidin-4-yl) decanedioate, and the molecular formula is C28H52N2O4, Recommanded Product: Bis(2,2,6,6-tetramethylpiperidin-4-yl) decanedioate.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Davand, Razieh published the artcileTheoretical and experimental assessment of UV resistance of high-density polyethylene: Screening and optimization of hindered amine light stabilizers, Synthetic Route of 52829-07-9, the main research area is hindered amine stabilizer polyethylene UV resistance.

Hindered amine light stabilizers (HALS) are widely used chem. stabilizers for preventing polymer degradation In this study, the effects of type of HALS and its content in high-d. polyethylene (HDPE) over the stabilization process are investigated employing d. functional theory (DFT) and exptl. approach. The electrophilicity index of four types of com. HALS are compared by DFT to select the most effective one. Besides, the HDPE sample containing a phenolic antioxidant and different contents of the selected HALS are exptl. exposed to UV irradiation The effect of HALS content on the changes in chain microstructure and mol. weight of HDPE are evaluated using gel permeation chromatog. and frequency sweep rheometry. In the absence of HALS, HDPE suffers degradation and the phenolic antioxidant causes chain scission. However, by adding HALS, the chain branching and crosslinking mechanisms are predominant. The results of FTIR, DSC, and tensile analyses follow similar trends, revealing that the best stabilization performance corresponds to adding 600 ppm HALS to HDPE.

Journal of Applied Polymer Science published new progress about Crystallinity. 52829-07-9 belongs to class piperidines, name is Bis(2,2,6,6-tetramethylpiperidin-4-yl) decanedioate, and the molecular formula is C28H52N2O4, Synthetic Route of 52829-07-9.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Shi, Jia published the artcileEvaluation of thermoplastic polyolefin materials for the hard shed of composite insulators, Application of Bis(2,2,6,6-tetramethylpiperidin-4-yl) decanedioate, the main research area is polyolefin material hard shed composite insulator hydrophobicity transfer property.

This article explores the possibility of using polyolefin materials for composite insulator sheds. The transfer component (silicone oil or erucamide) is added into a polyolefin material to improve its hydrophobic properties. Results show that the silicone oil-modified polyolefin material (polyolefin-S) exhibited an obvious hydrophobicity transfer property. When the equivalent salt deposit d. and nonsol. deposit d. are 0.1 and 0.5 mg/cm2, resp., the static contact angle increases from 75° to 87° as the silicone oil transfer time increases from 24 to 96 h. Meanwhile, polyolefin-S exhibits high mech. strength, hardness, volume resistivity, and surface resistivity values of 21.4 MPa, 62.6 HD, 1.7 × 1015 Ω m and 1.2 × 1016 Ω, resp. Moreover, polyolefin-S shows excellent tracking and erosion resistance of 4.5 kV level in the inclined plane test. The results verify that the polyolefin material is a promising candidate material for the hard shed of composite insulators.

Journal of Applied Polymer Science published new progress about Contact angle. 52829-07-9 belongs to class piperidines, name is Bis(2,2,6,6-tetramethylpiperidin-4-yl) decanedioate, and the molecular formula is C28H52N2O4, Application of Bis(2,2,6,6-tetramethylpiperidin-4-yl) decanedioate.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Gawley, Robert E. published the artcile2-Lithio-N-methylpiperidine and 2-lithio-N-methylpyrrolidine: configurationally and chemically stable unchelated α-aminoorganolithiums, Computed Properties of 1690-74-0, the main research area is lithiomethylpiperidine preparation configurational stability; lithiomethylpyrrolidine preparation configurational stability; piperidine lithiomethyl preparation configurational stability; pyrrolidine lithiomethyl preparation configurational stability.

Enantiomerically pure 2-lithio-N-methylpiperidine and enantiomerically enriched 2-lithio-N-methylpyrrolidine (94% ee) have been made by tin-lithium exchange and evaluated for their chem. and configurational stability. Both show remarkable stability in the presence of TMEDA, resisting racemization at temperatures up to -40°.

Journal of the American Chemical Society published new progress about Configuration. 1690-74-0 belongs to class piperidines, name is Methyl 1-methylpiperidine-2-carboxylate, and the molecular formula is C8H15NO2, Computed Properties of 1690-74-0.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Blank, Brian R. published the artcileAntimalarial Trioxolanes with Superior Drug-Like Properties and In Vivo Efficacy, Name: tert-Butyl piperidin-4-ylcarbamate, the main research area is antimalarials endoperoxides trioxolanes lead optimization stereoselective synthesis; antimalarials; endoperoxides; lead optimization; stereoselective synthesis; trioxolanes.

The emergence of artemisinin resistance, combined with certain suboptimal properties of ozonide agents arterolane and artefenomel, has necessitated the search for new drug candidates in the endoperoxide class. Our group has focused on trioxolane analogs with substitution patterns not previously explored. Here, we describe the enantioselective synthesis of analogs bearing a trans-3” carbamate side chain and find these to be superior, both in vitro and in vivo, to the previously reported amides. We identified multiple analogs that surpass the oral efficacy of arterolane in the Plasmodium berghei model while exhibiting drug-like properties (logD, solubility, metabolic stability) similar or superior to next-generation clin. candidates like E209 and OZ609. While the preclin. assessment of new analogs is still underway, current data suggest the potential of this chemotype as a likely source of future drug candidates from the endoperoxide class.

ACS Infectious Diseases published new progress about Antimalarials. 73874-95-0 belongs to class piperidines, name is tert-Butyl piperidin-4-ylcarbamate, and the molecular formula is C10H20N2O2, Name: tert-Butyl piperidin-4-ylcarbamate.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Buravchenko, Galina I. published the artcileDiscovery of derivatives of 6(7)-amino-3-phenylquinoxaline-2-carbonitrile 1,4-dioxides: novel, hypoxia-selective HIF-1α inhibitors with strong antiestrogenic potency, Quality Control of 73874-95-0, the main research area is amino phenylquinoxaline carbonitrile dioxide preparation anticancer antiestrogenic activity; Antiestrogenic potency; Antiproliferative activity; ERK 1/2 signaling pathway; HIF-1α; Hypoxia selectivity; Quinoxaline-2-carbonitrile 1,4-dioxide.

The synthesis of 3-phenylquinoxaline-2-carbonitrile 1,4-dioxides bearing cyclic diamine residues at positions 6 or 7 I (R = H, piperazin-1-yl, 3-methylpiperazin-1-yl, 3-aminopyrrolidin-1-yl, etc.; R1 = F, Cl, 3-methylpiperazin-1-yl, etc.) based on the nucleophilic substitution of halogens has been described. All synthesized 6(7)-aminoquinoxaline-2-carbonitrile 1,4-dioxides I demonstrated higher cytotoxicity and hypoxia selectivity compared to the reference agent tirapazamine against breast adenocarcinoma cell lines (MCF7, MDA-MB-231). The structure and position of the diamine residue considerably affect the antiproliferative properties of the quinoxaline-2-carbonitrile 1,4-dioxides I. The introduction of a halogen atom at position 7 in the quinoxaline ring of I (R = piperazin-1-yl; R1 = H) considerably increases the cytotoxicity of compounds I [R = piperazin-1-yl; R1 = F, Cl] under both normoxic and hypoxic conditions. However, the most hypoxia-selective derivatives were non-halogenated 7-aminosubstituted 3-phenylquinoxaline-2-carbonitrile 1,4-dioxides I (R = H; R1 = piperazin-1-yl, 3-methylpiperazin-1-yl, 3-aminopyrrolidin-1-yl, etc.). Of the 32 novel synthesized derivatives, I approx. some of the 6(7)-amino-3-phenylquinoxaline-2-carbonitrile 1,4-dioxides demonstrated high antiproliferative potency against wild type leukemia cells K562 and drug-resistant subline K562/4 with the expression of p-glycoprotein (p-gp) compared to the reference agent doxorubicin, which exhibited one order of magnitude lower activity towards K562/4 cells than towards K562 cells. Lead compounds I (R = piperazin-1-yl; R1 = F) and I [R = H; R1 = (3S)-3-aminopyrrolidin-1-yl] inhibited HIF-1α expression and activity and induced apoptosis in hypoxic tumor cells, which was confirmed by poly(ADP-ribose)polymerase (PARP) cleavage. Moreover, I (R = piperazin-1-yl; R1 = F) and I [R = H; R1 = (3S)-3-aminopyrrolidin-1-yl] showed strong antiestrogenic potencies in MCF7 breast cancer cells. Thus, the described series of quinoxaline 1,4-dioxides I has high anticancer potential and good aqueous solubility Therefore, these compounds are promising for further drug development of hypoxia-targeted anticancer agents.

Bioorganic Chemistry published new progress about Antiestrogens. 73874-95-0 belongs to class piperidines, name is tert-Butyl piperidin-4-ylcarbamate, and the molecular formula is C10H20N2O2, Quality Control of 73874-95-0.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Portela, Raquel published the artcileMonolithic SiC supports with tailored hierarchical porosity for molecularly selective membranes and supported liquid-phase catalysis, Safety of Bis(2,2,6,6-tetramethylpiperidin-4-yl) decanedioate, the main research area is silicon carbide monolithic tailored hierarchical porosity liquid phase catalysis.

Monolithic support materials with the mech. resistance and thermal conductivity of SiC as well as tunable surface chem. and textural properties were developed for their use in catalytic membrane reactors. After heat treatment, the extruded SiC monoliths have a monomodal distribution of macropores of a few μm in diameter depending on the particle size of the starting material. A macroporous, defect-free, smoother skin was applied onto the external wall using a solution of sub-micrometer SiC particles. These monoliths with skin could be coated successfully with molecularly selective membranes, and thus have application in membrane reactor processes. Finally, metal oxide nanoparticles were infiltrated into the macropores to modify the surface texture and chem., allowing the immobilization of liquid phase catalysts. The resulting multimodal distribution of pore sizes could be tuned by the choice of SiC and oxide particle sizes, number of wash-coats and calcination temparature. Mesopores created between nanoparticles had diameters of roughly 40% of those of the nanoparticles. Small macropores, between 10-1000 nm, were also created, with bigger size and volume at higher calcination temparatures due to the metal oxide particles contraction. The developed materials were validated as support for PDMS membranes and for continuous gas-phase hydroformylation of 1-butene using Rh-diphosphite catalysts.

Catalysis Today published new progress about Agglomeration. 52829-07-9 belongs to class piperidines, name is Bis(2,2,6,6-tetramethylpiperidin-4-yl) decanedioate, and the molecular formula is C28H52N2O4, Safety of Bis(2,2,6,6-tetramethylpiperidin-4-yl) decanedioate.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Mayer, Brian P. published the artcileStatistical analysis of the chemical attribution signatures of 3-methylfentanyl and its methods of production, Category: piperidines, the main research area is forensic chem attribution signature methylfentanyl; 3-methylfentanyl; Chemical attribution signature; Chemical forensics; Forensic attribution; Machine learning; Opioid.

Chem. attribution of the origin of an illegal drug is a key component of forensic efforts aimed at combating illicit and clandestine manufacture of drugs and pharmaceuticals. The results of these studies yield detailed information on synthesis byproducts, reagents, and precursors that can be used to identify the method of manufacture In the present work, chem. attribution signatures (CAS) associated with the synthesis of the analgesic 3-methylfentanyl, N-(3-methyl-1-phenethylpiperidin-4-yl)-N-phenylpropanamide, were investigated. Eighteen crude samples from six synthesis methods were generated, the anal. of which was used to identify signatures (i.e., chem. compounds) that were important in the discrimination of synthetic route. These methods were carefully selected to minimize the use of scheduled precursors, complicated laboratory equipment, number of steps, and extreme reaction conditions. Using gas and liquid chromatogs. combined with time-of-flight mass spectrometry (GC-QTOF and LC-QTOF) over 160 distinct species were monitored. Anal. of this combined data set was performed using modern machine learning techniques capable of reducing the size of the data set, prioritizing key chem. attribution signatures, and identifying the method of production for blindly synthesized 3-methylfentanyl materials.

Talanta published new progress about Drugs of abuse. 5773-58-0 belongs to class piperidines, name is 3-Methylpiperidin-4-one, and the molecular formula is C6H11NO, Category: piperidines.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Manz, Theresa D. published the artcileStructure-Activity Relationship Study of Covalent Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors, Related Products of piperidines, the main research area is phosphatidylinositol 5 phosphate 4 kinase inhibitor THZP12 PI5P4K.

Phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) are important mol. players in a variety of diseases, such as cancer. Currently available PI5P4K inhibitors are reversible small mols., which may lack selectivity and sufficient cellular on-target activity. In this study, we present a new class of covalent pan-PI5P4K inhibitors with potent biochem. and cellular activity. Our designs are based on THZ-P1-2, a covalent PI5P4K inhibitor previously developed in our laboratory Here, we report further structure-guided optimization and structure-activity relationship (SAR) study of this scaffold, resulting in compound 30(I), which retained biochem. and cellular potency, while demonstrating a significantly improved selectivity profile. Furthermore, we confirm that the inhibitors show efficient binding affinity in the context of HEK 293T cells using isothermal CETSA methods. Taken together, I represents a highly selective pan-PI5P4K covalent lead mol.

ACS Medicinal Chemistry Letters published new progress about Drug discovery. 73874-95-0 belongs to class piperidines, name is tert-Butyl piperidin-4-ylcarbamate, and the molecular formula is C10H20N2O2, Related Products of piperidines.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem