Day: November 3, 2022

Rafiq, Kiran; Saify, Zafar Saied; Vaid, Faiyaz; Navaid, Farzana; Kamil, Arfa; Kausar, Rana; Ghous, Asghari published an article in 2013, the title of the article was Synthesis of 4-(4′-chlorophenyl)-4-hydroxy piperidine analogues having promising compatibility with alpha amylase enzyme.Product Details of 39512-49-7 And the article contains the following content:

A new series of 4-(4′-Chlorophenyl)-4-hydroxy piperidine derivatives I·HX [R = adamantan-1-acyl, 6-methyluracil, 3-phenoxy-1-Pr, 3-phenyl-1-propyl] were synthesized with different phenacyl halide. All synthesized compounds were screened for their in vitro antiamylatic activity by semiquant. agar plate method. The parent compound 4-(4′-Chlorophenyl)-4-hydroxy piperidine showed moderate while I·HX [R = adamantan-1-acyl, 3-phenoxy-1-Pr, 3-phenyl-1-propyl] showed good antiamylatic activity. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Product Details of 39512-49-7

The Article related to chlorophenyl hydroxy piperidine preparation antiamylase, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Product Details of 39512-49-7

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

On June 30, 2016, Bradner, James; Buckley, Dennis; Winter, Georg published a patent.Application of 1216805-11-6 The title of the patent was Methods to induce targeted protein degradation through bifunctional molecules. And the patent contained the following:

The present application provides bifunctional compounds which act as protein degradation inducing moieties. The present application also relates to methods for the targeted degradation of endogenous proteins through the use of the bifunctional compounds that link a cereblon-binding moiety to a ligand that is capable of binding to the targeted protein which can be utilized in the treatment of proliferative disorders. The present application also provides methods for making compounds of the application and intermediates thereof. The experimental process involved the reaction of 2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindoline-5-carboxylic acid(cas: 1216805-11-6).Application of 1216805-11-6

The Article related to targeted protein degradation bifunctional mol preparation, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application of 1216805-11-6

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

On July 31, 2018, Rafiq, Kiran; Saify, Zafar Saied; Nesar, Shagufta; Faiyaz, Ambreen; Muhammad, Iyad Naeem published an article.COA of Formula: C11H14ClNO The title of the article was Some novel piperidine analogues having strong alpha glucosidase inhibition. And the article contained the following:

In the present work some hydroxy piperidine analogs have been synthesized and analyzed for their hypoglycemic effect through glucosidase inhibition owing to the structural resemblance with nojirimycin. The activity was done by spectral absorbance anal. using acarbose as standard Two analogs 1-(1”-phenoxypropyl)-4-phenyl-4-hydroxy piperidinium hydrobromide and 1-(1”-adamantan acyl)-4-(4′-bromophenyl)-4-hydroxy piperidinium hydrobromide were found to pose excellent activity having 87.4 and 54.7% inhibition resp., hence strengthening the idea of studying piperidine analogs as glucosidase inhibitors due to structural similarity with nojirimycin. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).COA of Formula: C11H14ClNO

The Article related to piperidine derivative preparation alpha glucosidase inhibitor, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.COA of Formula: C11H14ClNO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

On June 12, 2014, Frei, Beat; Gobbi, Luca; Grether, Uwe; Kimbara, Atsushi; Nettekoven, Matthias; Roever, Stephan; Rogers-Evans, Mark; Schulz-Gasch, Tanja published a patent.Safety of tert-Butyl 4-amino-4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate The title of the patent was Preparation of novel pyridine derivatives as cannabinoid receptor 2 agonists. And the patent contained the following:

The title compounds I [R1 = halo, cycloalkylalkoxy, alkylsulfonyl, etc.; R2 = halo, cycloalkyl, haloalkyl, etc.; R3 = (alkyl)(oxo)pyrrolidinyl or C(R4R5)C(R6R7)C(O)R8; R4, R5 = H, alkyl, Ph, etc.; or R4 and R5 together with the carbon atom to which they are attached form cycloalkyl, oxetanyl, thiethanyl, etc.; R6, R7 = H, alkyl; or one of R4 and R5 and one of R6 and R7, together with the carbon atoms to which they are attached, form cycloalkyl, and the other ones are both hydrogen at the same time; R8 = NH2, alkoxy, alkylamino, OH], useful as CB2 receptor agonists were prepared and formulated. E.g., a multi-step synthesis of the amide II, starting from Me 5-bromo-pyridine-2-carboxylate, was described. The exemplified compounds I showed an excellent affinity for the CB2 receptor with affinities below 10 μM (specific data given). The experimental process involved the reaction of tert-Butyl 4-amino-4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate(cas: 362703-57-9).Safety of tert-Butyl 4-amino-4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate

The Article related to pyridine amide preparation cannabinoid receptor 2 cb2 agonist, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Safety of tert-Butyl 4-amino-4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

On January 27, 2022, Lee, Song Hee; Ryu, Je Ho; Ahn, Jung Min; Choi, Yu Ri; Lee, Ho Hyun; Jang, Mi Young; Woo, Yae Jin; Kim, Hanwool; Kim, Ji Young; Park, Ji Youn published a patent.Recommanded Product: 1262988-77-1 The title of the patent was Amide compound for androgen receptor degradation, and pharmaceutical use thereof. And the patent contained the following:

The present invention provides a compound I [R1 = H, alkyl, halogen, etc.; R2 = H, alkyl, halogen, etc.; X1, X3, X4 and X5 = independently CH or N; X2 = CR3 or N; R3 = H, alkyl, halogen, etc.; n = 0, 1, or 2; m = 0 or 1; L = -(CH2)q1-A1-(CH2)q2-B1-(CH2)q3-A2-(CH2)q4-B2-(CH2)q5-A3-(CH2)q6-B3-; A1, A2 and A3 = independently direct bond, -O-, -N(R4)-, etc.; R4 = H, alkyl or haloalkyl; B1, B2 and B3 = independently direct bond, cycloalkyl, heterocycle, etc.; q1-q6 = independently 0-6; E = Q1 or Q2; X6, X7, X8 and X9 = independently CH or N; Y = -C(R6)2-, -C(O)-, -C(R6)2-C(R6′)2-, etc.; Z = direct bond, -C(R6)2-, -O-, etc.; R5 and R5′ = independently H, alkyl, halogen, etc.; R6 and R6′ = independently H, alkyl, halogen, etc.] of a specific chem. structure, having androgen receptor (AR) degradation activity, or a pharmaceutically acceptable salt thereof. The present invention also provides a composition containing the compound or a pharmaceutically acceptable salt thereof. According to present invention, provided is a pharmaceutical use of the compound, the salt thereof, and the composition containing same for treating or preventing AR-related diseases. According to the present invention, further provided is a method for treating or preventing AR-related diseases, the method comprising administering, to a subject in need of treatment, an effective amount of the compound, the salt thereof, or the composition containing same. For example, compound II (preparation given) was coupled with compound III (preparation given) to provide compound IV. The experimental process involved the reaction of 1-Benzyl-4-hydroxypiperidine-4-carboxylic acid hydrochloride(cas: 1262988-77-1).Recommanded Product: 1262988-77-1

The Article related to amide compound preparation androgen receptor degradation activity, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Recommanded Product: 1262988-77-1

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

On January 1, 2014, Hatae, Noriyuki; Nagayama, Tomoyuki; Esaki, Hiroyoshi; Kujime, Eiko; Minami, Masabumi; Ishikura, Minoru; Choshi, Tominari; Hibino, Satoshi; Okada, Chiaki; Toyota, Eiko; Nagasawa, Hideko; Iwamura, Tatsunori published an article.Application of 39512-49-7 The title of the article was Synthesis of 4-arylpiperidin-4-ol derivatives of loperamide as agents with potent antiproliferative effects against HCT-116 and HL-60 cells. And the article contained the following:

The synthesis of 4-arylpiperidin-4-ol derivatives of loperamide I [R1 = n-Pr, Ph2C(OH)CH2, R2 = 4-ClC6H4; R1 = Ph2C(OH)CH2CH2, R2 = Ph, 4-ClC6H4, 3-F3CC6H4] and N-(3-hydroxy-3,3-diphenylpropyl)piperidine was carried out by alkylation of the corresponding N-unsubstituted piperidines. The synthesized compounds were tested for their antiproliferative activity against HCT-116 cells and HL-60 cells. The N-substituents on 4-arylpiperidin-4-ol units were found to play an important role in their antiproliferative activity, and the N-diphenylpropanol analogs exhibited the most potent antiproliferative activity. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Application of 39512-49-7

The Article related to piperidinol aryl preparation loperamide antiproliferative activity, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application of 39512-49-7

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Ibis, Cemil; Ayla, Sibel Sahinler; Bahar, Hakan; Stasevych, Maryna V.; Komarovska-Porokhnyavets, Olena; Novikov, Volodymyr published an article in 2015, the title of the article was Synthesis, Characterization, and Biological Properties of Novel Piperidinolyl-, Piperidinyl-, and Piperazinyl-Substituted Naphthoquinone Compounds and Their Reactions With Some Thiols.Electric Literature of 39512-49-7 And the article contains the following content:

Nucleophilic substitution reactions of 2,3-dichloro-1,4-naphthoquinone were studied using a variety of piperidinol, piperidine, and piperazine derivatives The N-substituted compounds were treated with some thiols and N,S-substituted compounds were formed. The structures of the new products were characterized by spectroscopic methods (1H NMR, 13C NMR, MS) and elemental anal. The novel compounds were evaluated for their antibacterial and antifungal activity. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Electric Literature of 39512-49-7

The Article related to naphthoquinone derivative preparation antibacterial antifungal activity, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Electric Literature of 39512-49-7

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

On January 11, 2018, Amata, Emanuele; Rescifina, Antonio; Prezzavento, Orazio; Arena, Emanuela; Dichiara, Maria; Pittala, Valeria; Montilla-Garcia, Angeles; Punzo, Francesco; Merino, Pedro; Cobos, Enrique J.; Marrazzo, Agostino published an article.Recommanded Product: 39512-49-7 The title of the article was (+)-Methyl (1R,2S)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties. And the article contained the following:

Methoxycarbonyl-1-phenyl-2-cyclopropylmethyl based derivatives [cis-(+)-MR200], [cis-(-)-MR201], and [trans-(±)-MR204], have been identified as new potent sigma (σ) receptor ligands. In the present paper, novel enantiomerically pure analogs were synthesized and optimized for their σ receptor affinity and selectivity. Docking studies rationalized the results obtained in the radioligand binding assay. Absolute stereochem. was unequivocally established by X-ray anal. of a precursor as camphorsulfonyl derivative The most promising compound, I, showed remarkable selectivity over a panel of more than 15 receptors as well as good chem. and enzymic stability in human plasma. An in vivo evaluation evidenced that I, in contrast to its isomers, which behave as σ1 antagonists, exhibited a σ1 agonist profile. These data clearly demonstrated that compound I, due to its σ1 agonist activity and favorable receptor selectivity and stability, provided an useful tool for the study of σ1 receptors. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Recommanded Product: 39512-49-7

The Article related to cyclopropylmethyl piperidine receptor sigma ligand neurodegenerative disorder human, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Recommanded Product: 39512-49-7

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Filer, Crist N.; Egan, Judith A.; Nugent, Richard P. published an article in 2014, the title of the article was Synthesis and characterization of [N-methyl-3H]loperamide.Application In Synthesis of 4-(4-Chlorophenyl)piperidin-4-ol And the article contains the following content:

Loperamide is a piperidine butyramide mu-opiate receptor agonist and currently employed to treat diarrhea. Because a single past report of tritiating loperamide was limited to only a very low specific activity product without tech. details or extensive anal., the synthesis of [N-methyl-3H]loperamide at high specific activity was now described in detail. An imine precursor was alkylated with [3H]methyl iodide to obtain a quaternary intermediate, which was then reacted with 4-(4-chlorophenyl)-4-hydroxypiperidine to afford the desired product [N-methyl-3H]loperamide, characterized by thin layer chromatog. (TLC), HPLC, MS, UV, and proton-decoupled tritium NMR. Copyright © 2014 John Wiley & Sons, Ltd. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Application In Synthesis of 4-(4-Chlorophenyl)piperidin-4-ol

The Article related to tritium labeled loperamide synthesis, loperamide, mu-opiate receptor, tritium, tritium nmr, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application In Synthesis of 4-(4-Chlorophenyl)piperidin-4-ol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

On February 3, 2011, Ackermann, Jean; Conte, Aurelia; Hunziker, Daniel; Neidhart, Werner; Nettekoven, Matthias; Wertheimer, Stanley published a patent.HPLC of Formula: 1262988-77-1 The title of the patent was Piperidine-4-carboxamide derivatives as hormone sensitive lipase (HSL) inhibitors and their preparation and use for the treatment of diseases. And the patent contained the following:

The invention relates to piperidine-4-carboxamide derivatives of formula I, which are hormone sensitive lipase (HSL) inhibitors and which are useful in the treatment of diseases. Compounds of formula I wherein R1 is alkyl, cycloalkyl, haloalkyl, etc.; R2 is H, alkyl and cycloalkyl; R3 is (un)substituted indanyl, (un)substituted pyridinyl, (un)substituted pyrimidyl, etc.; R4 is H, alkyl and cycloalkyl; A1 is carbonyl, SO2, NHCO, etc.; A2 is O and NH and derivatives; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). All the invention compounds were evaluated for their HSL inhibitory activity. From the assay, it was determined that compound II exhibited an IC50 value of 0.04 μM. The experimental process involved the reaction of 1-Benzyl-4-hydroxypiperidine-4-carboxylic acid hydrochloride(cas: 1262988-77-1).HPLC of Formula: 1262988-77-1

The Article related to piperidinecarboxamide preparation hormone sensitive lipase hsl inhibitor treatment disease, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.HPLC of Formula: 1262988-77-1

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem