Month: October 2022

Safety of Cis-piperidine-2,6-dicarboxylic acidOn October 31, 1982 ,《The excitatory actions of a series of piperidine dicarboxylates on central neurons of the rat, snail, leech, and horseshoe crab and on crab neuromuscular junction》 was published in Comparative Biochemistry and Physiology, C: Comparative Pharmacology. The article was written by King, D. J.; McBain, Anne E.; Jais, M. Mat; Roberts, C. Jane; Collins, J. F.; Wheal, H. V.; Walker, R. J.. The article contains the following contents:

The 2,3- [46026-75-9], 2,4- [84211-45-0], 2,5- [84619-48-7], and 2,6-piperidine dicarboxylates [59234-40-1] were devoid of direct or indirect effects of the Helix neuron; the 2,5-analog mimicked the actions of L-glutamate (I) [56-86-0] on Limulus neurons, and these were inhibited by I. All 4 piperidines mimicked the actions of I on Hirudo and rat neurons and Eupagurus muscle. All were weak agonists on rat neurons, whereas on Hirudo neurons the 2,5-analog was the most potent; on the Eupagurus muscle the 2,3- and 2,6-analogs were the most potent. All 4 piperidines potentiated the action of I on rat and Hirudo neurons and on Eupagurus leg muscle and of muscle excitatory junction potentials. Thus, there are probably differences between I receptors used in the study, and the preferred conformation for I on crab leg muscle may be the partially folded one and that for Hirudo neurons is more extended. The experimental part of the paper was very detailed, including the reaction process of Cis-piperidine-2,6-dicarboxylic acid(cas: 59234-40-1Safety of Cis-piperidine-2,6-dicarboxylic acid)

Cis-piperidine-2,6-dicarboxylic acid(cas: 59234-40-1) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Safety of Cis-piperidine-2,6-dicarboxylic acid

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Reference of TriacetonamineOn October 1, 2022 ,《Plasmonic silica-gold core-shell nanoparticles: Interaction with organic dyes for light-induced applications》 was published in Journal of Photochemistry and Photobiology, A: Chemistry. The article was written by Martinez Porcel, Joaquin E.; Churio, Maria S.; Moya, Sergio E.; Arce, Valeria B.; Martire, Daniel O.. The article contains the following contents:

The interaction of plasmonic nanoparticles with ground- and excited states of dyes can strongly affect the fluorescence of the organic mols., as well as the generation of reactive oxygen species (ROS). This interaction can be exploited in bioimaging and photodynamic therapy (PDT) of tumors. In this line, we prepare here gold-decorated silica nanoparticles (SiO2@Au NPs) via a novel method, which combines the synthesis of gold nuclei through reduction of a Au3+ salt, with a photochem. route driving the growth of the metallic nuclei. In this hybrid nanomaterial, the surface groups of the silica particle can potentially act as adsorption sites for the dyes in a range close to the gold nanoparticles, favoring the interaction. The ability of SiO2@Au NPs to enhance fluorescence and generation of ROS upon irradiation of riboflavin and Rose Bengal is evaluated. SiO2@Au enhance the fluorescence emission of both dyes, although through different mechanisms. The excitation of the flavin is enhanced, whereas for Rose Bengal the radiative decay rate is increased by the nanoparticles. For neither of the two dyes, SiO2@Au affect ROS generation as measured by ESR (EPR) spectroscopy. However, the increase in fluorescence emission observed for both dyes demonstrates the potential application of SiO2@Au in fluorescence-sensing methods and bioimaging. After reading the article, we found that the author used Triacetonamine(cas: 826-36-8Reference of Triacetonamine)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.Reference of Triacetonamine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Electric Literature of C6H12N2OOn March 31, 2021, Xin, Chao; Cheng, Cuilin; Hou, Kexin; Bao, Meili; Zhang, Hua; Wang, Zhenyu published an article in Materials Science & Engineering, C: Materials for Biological Applications. The article was 《A novel melanin complex displayed the affinity to HepG2 cell membrane and nucleus》. The article mentions the following:

Chitosan-melanin complex from Catharsius molossus L. has proven to possess superior pharmaceutical excipient performance and may be the new source of water-soluble protein-free natural melanin. Herein, it was enzymically hydrolyzed into the chitooligosaccharide-melanin complex (CMC) whose main chem. units were composed of eumelanin and chitooligosaccharides and showed three-layer structures. Addnl., this biomacromol. could self-assemble into 40 nm nanoparticles (CMC Nps) in a weakly acidic aqueous solution Interestingly, CMC displayed strong affinity for cell membrane by binding the phosphatidylserine, glycoprotein, glycolipids and glycosaminoglycans accumulated on the surface of tumor cells, notably, CMC Nps could enter cells and mainly target the nucleus by interacting with DNA and/or RNA substrates located around the nucleus to disrupt the proliferation and apoptosis processes. The findings suggest CMC may be the novel material for subcellular organelle targeting of cancer cells.Piperidine-4-carboxamide(cas: 39546-32-2Electric Literature of C6H12N2O) was used in this study.

Piperidine-4-carboxamide(cas: 39546-32-2) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Electric Literature of C6H12N2O

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Zhang, Jianjun; Zhang, Kaiyu; Liang, Xian; Yu, Weisheng; Ge, Xiaolin; Shehzad, Muhammad A.; Ge, Zijuan; Yang, Zhengjin; Wu, Liang; Xu, Tongwen published an article in 2021. The article was titled 《Self-aggregating cationic-chains enable alkaline stable ion-conducting channels for anion-exchange membrane fuel cells》, and you may find the article in Journal of Materials Chemistry A: Materials for Energy and Sustainability.Computed Properties of C6H11NO The information in the text is summarized as follows:

Precise manipulation of the polyelectrolyte self-assembly process, to form the desired microstructure with ion-conducting channels, is of fundamental and technol. importance to many fields, such as fuel cells, flow batteries and electrodialysis. To fabricate anion exchange membranes (AEMs) with highly conductive and alk. stable ion-conducting channels, we hereby report a strategy for designing self-aggregating side chains with optimized alk. stability, by inserting dipolar ethylene oxide (EO) spacers in the cationic side chain. Simulation and nano-scale microscopy analyses verify the self-assembly process of the flexible side chain with cation-dipole interaction to construct interconnected ionic highways for fast water and ion transportation. The resulting O-PDQA AEM exhibits higher hydroxide conductivity (106 mS cm-1 at 80 °C) and a competitive peak power d. (1.18 W cm-2 at 70 °C) in alk. H2/O2 single-cell fuel cells. Moreover, O-PDQA shows excellent alk. stability with over 96% conductivity retention after storage in 2 M NaOH solution at 80 °C for 1080 h. This new concept of introducing dipolar moieties in the cationic side chain can accelerate the development of technologies that involve polyelectrolytes. The experimental part of the paper was very detailed, including the reaction process of 1-Methyl-4-piperidone(cas: 1445-73-4Computed Properties of C6H11NO)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.Computed Properties of C6H11NO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Pei, Dan-Ni; Liu, Chang; Zhang, Ai-Yong; Pan, Xiao-Qiang; Yu, Han-Qing published their research in Proceedings of the National Academy of Sciences of the United States of America on December 8 ,2020. The article was titled 《In situ organic Fenton-like catalysis triggered by anodic polymeric intermediates for electrochemical water purification》.Product Details of 826-36-8 The article contains the following contents:

Organic Fenton-like catalysis was recently developed for water purification, but redox-active compounds have to be ex situ added as oxidant activators, causing secondary pollution problem. Electrochem. oxidation is widely used for pollutant degradation, but suffers from severe electrode fouling caused by high-resistance polymeric intermediates. Herein, the authors develop an in situ organic Fenton-like catalysis by using the redox-active polymeric intermediates, e.g., benzoquinone, hydroquinone, and quinhydrone, generated in electrochem. pollutant oxidation as H2O2 activators. By taking phenol as a target pollutant, the in situ organic Fenton-like catalysis not only improves pollutant degradation, but also refreshes working electrode with a better catalytic stability. Both 1O2 nonradical and A·OH radical are generated in the anodic phenol conversion in the in situ organic Fenton-like catalysis. The authors’ findings might provide a new opportunity to develop a simple, efficient, and cost-effective strategy for electrochem. water purification In the part of experimental materials, we found many familiar compounds, such as Triacetonamine(cas: 826-36-8Product Details of 826-36-8)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.Product Details of 826-36-8

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In 2019,Proceedings of the National Academy of Sciences of the United States of America included an article by Hong, W. David; Benayoud, Farid; Nixon, Gemma L.; Ford, Louise; Johnston, Kelly L.; Clare, Rachel H.; Cassidy, Andrew; Cook, Darren A. N.; Siu, Amy; Shiotani, Motohiro; Webborn, Peter J. H.; Kavanagh, Stefan; Aljayyoussi, Ghaith; Murphy, Emma; Steven, Andrew; Archer, John; Struever, Dominique; Frohberger, Stefan J.; Ehrens, Alexandra; Hubner, Marc P.; Hoerauf, Achim; Roberts, Adam P.; Hubbard, Alasdair T. M.; Tate, Edward W.; Serwa, Remigiusz A.; Leung, Suet C.; Qie, Li; Berry, Neil G.; Gusovsky, Fabian; Hemingway, Janet; Turner, Joseph D.; Taylor, Mark J.; Ward, Stephen A.; O’Neill, Paul M.. Electric Literature of C7H15NO. The article was titled 《AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis》. The information in the text is summarized as follows:

Onchocerciasis and lymphatic filariasis are two neglected tropical diseases that together affect ∼ 157 million people and inflict severe disability. Both diseases are caused by parasitic filarial nematodes with elimination efforts constrained by the lack of a safe drug that can kill the adult filaria (macrofilaricide). Previous proof-of-concept human trials have demonstrated that depleting > 90% of the essential nematode endosymbiont bacterium, Wolbachia, using antibiotics, can lead to permanent sterilization of adult female parasites and a safe macrofilaricidal outcome. AWZ1066S is a highly specific anti-Wolbachia candidate selected through a lead optimization program focused on balancing efficacy, safety and drug metabolism/pharmacokinetic (DMPK) features of a thienopyrimidine/quinazoline scaffold derived from phenotypic screening. AWZ1066S shows superior efficacy to existing anti-Wolbachia therapies in validated preclin. models of infection and has DMPK characteristics that are compatible with a short therapeutic regimen of 7 days or less. This candidate mol. is well-positioned for onward development and has the potential to make a significant impact on communities affected by filariasis. The experimental process involved the reaction of 2-(Piperidin-4-yl)ethanol(cas: 622-26-4Electric Literature of C7H15NO)

2-(Piperidin-4-yl)ethanol(cas: 622-26-4) can be used to synthese ursolic acid derivatives, spiroimidazolidinone NPC1L1 inhibitors, neurokinin-2 receptor antagonists, antagonists for inhibition of platelet aggregation.Electric Literature of C7H15NO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Turk, Benjamin E.; Jiang, Hongsi; Liu, Jun O. published an article in Proceedings of the National Academy of Sciences of the United States of America. The title of the article was 《Binding of thalidomide to α1-acid glycoprotein may be involved in its inhibition of tumor necrosis factor α production》.Computed Properties of C13H14N2O4 The author mentioned the following in the article:

In addition to its well known sedative and teratogenic effects, thalidomide also possesses potent immunomodulatory and antiinflammatory activities, being most effective against leprosy and chronic graft-vs.-host disease. The immunomodulatory activity of thalidomide has been ascribed to the selective inhibition of tumor necrosis factor α from monocytes. The mol. mechanism for the immunomodulatory effect of thalidomide remains unknown. To elucidate this mechanism, we synthesized an active photoaffinity label of thalidomide as a probe to identify the mol. target of the drug. Using the probe, we specifically labeled a pair of proteins of 43-45 kDa with high acidity from bovine thymus extract Purification of these proteins and partial peptide sequence determination revealed them to be α1-acid glycoprotein (AGP). We show that the binding of thalidomide photoaffinity label to authentic human AGP is competed with both thalidomide and the nonradioactive photoaffinity label at concentrations comparable to those required for inhibition of production of tumor necrosis factor α from human monocytes, suggesting that AGP may be involved in the immunomodulatory activity of thalidomide. The experimental process involved the reaction of Benzyl (2,6-dioxopiperidin-3-yl)carbamate(cas: 24666-55-5Computed Properties of C13H14N2O4)

Benzyl (2,6-dioxopiperidin-3-yl)carbamate(cas: 24666-55-5) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Computed Properties of C13H14N2O4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

COA of Formula: C6H11NOIn 2021 ,《Design, synthesis of novel pyrazolopyridine derivatives and CREBBP bromodomain inhibitors docking and molecular dynamics》 appeared in Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry. The author of the article were Saamanthi, M.; Aruna, S.; Girija, R.; Vinod, D.. The article conveys some information:

A sequence of novel compounds pyrazolopyridines I [R = Ph, 2-phenylethenyl, 3-(trifluoromethyl)phenyl, 2,4-dimethylphenyl, etc.; X = O, S] have been prepared by a general synthetic method. Due to high efficiency and selectivity, anticancer agents consisting of combined mols. have gained great interests. The IC50 values have been determined against cell line U937, and the results obtained indicate the potential effects against cancer cell line. The cell potency of cell line is best for compounds I [R = 4-(trifluoromethyl)phenyl; X = O] IC50 = 62.5μM, I (R = Ph; X = S) IC50 = 62.5μM, I (R = Ph; X = O) IC50 = 31.2μM, I [R = 3-(trifluoromethyl)phenyl; X = O] IC50 = 31.2μM, selectivity and in vivo. Further, the mol. docking studies indicate that substituted pyrazolo[4,3-c]pyridine derivatives I show good anticancer activity in the medicinal field. The ease of synthesis and the significant biol. activities make these compounds I potential new frameworks for progress of cancer therapeutics. Compound I (R = 2,4-dimethylphenyl; X = O) shows anticancer effect in cancer cell lines and in vivo that corresponds with antitumor activity in an AML cancer type. For the mol. docking with the ligands, the RMSD value has been calculated, and the protein with the least RMSD is found to be 5KTU screening with 20 small mols. The experimental process involved the reaction of 1-Methyl-4-piperidone(cas: 1445-73-4COA of Formula: C6H11NO)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.COA of Formula: C6H11NO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Mohd Sarofil, Anith Dzhanxinah; Devina, Winda; Albertina, Ingrid; Chandra, Christian; Kim, Jaehoon published an article on February 25 ,2022. The article was titled 《Toad egg-like bismuth nanoparticles encapsulated in an N-doped carbon microrod via supercritical acetone as anodes in lithium-ion batteries》, and you may find the article in Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands).Recommanded Product: Triacetonamine The information in the text is summarized as follows:

A toad egg-inspired structure comprising bismuth (Bi) nanoparticles (NPs) contained in a carbon microrod shell (Bi@C) was synthesized via the one-pot supercritical acetone (scAct) route and subsequent carbonization. During the formation of Bi NPs in scAct in the presence of nitric acid, a few decomposed acetone mols. acted as carbon sources, which generated an albumen-like N-doped carbon microrod with an average shell thickness of 38 nm and were embedded with yolk-like Bi NPs having size in the range of 30-200 nm. The densely packed Bi NPs inside the carbon micron shell resulted in a high Bi loading of 78 wt%. When utilized for Li storage, the Bi@C delivered a high reversible capacity of 337 mAh g-1 after 70 cycles at 0.05 A g-1, long-term cyclability of 0.04 decay per cycle for 1000 cycles at 1 A g-1, and high volumetric energy d. of 870 mAh cm-3. The use of a mixed ether- and ester-based electrolyte in the Bi@C cell reduced the resistivity and increased the capacitive contribution, thereby resulting in a better high-rate performance and long-term stability than those obtained using conventional ester-based electrolytes. The experimental part of the paper was very detailed, including the reaction process of Triacetonamine(cas: 826-36-8Recommanded Product: Triacetonamine)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.Recommanded Product: Triacetonamine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Computed Properties of C10H12N2OOn October 31, 1994 ,《Synthesis of 3,5-lutidine by catalytic transfer hydrogenation via 1,2,5,6-tetrahydropyridine》 was published in Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry. The article was written by Sathe, Dhananjay G.; Kulkarni, Vithal M.. The article contains the following contents:

Substituted pyridines, e.g. 3,5-lutidine, have been prepared from the corresponding N-benzyl-1,2,5,6-tetrahydropyridines by catalytic transfer hydrogenation in one stage. A mechanism for such a catalytic transfer hydrogenation (CTH) has been proposed. In the experiment, the researchers used 1-Pyridin-4-ylpiperidin-4-one(cas: 126832-81-3Computed Properties of C10H12N2O)

1-Pyridin-4-ylpiperidin-4-one(cas: 126832-81-3) belongs to piperidines. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions. Computed Properties of C10H12N2O

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem