Day: October 21, 2022

《Design, physico-chemical characterization and in vitro biological activity of organogold(III) glycoconjugates》 was published in Dalton Transactions in 2021. These research results belong to Pettenuzzo, Andrea; Vezzu, Keti; Di Paolo, Maria Luisa; Fotopoulou, Eirini; Marchio, Luciano; Via, Lisa Dalla; Ronconi, Luca. Safety of Piperidine-4-carboxamide The article mentions the following:

To develop new metal-based glycoconjugates as potential anticancer agents, four organometallic Au(III)-dithiocarbamato glycoconjugates [Au(III)(2-Bnpy)(SSC-Inp-GlcN)](PF6) (2-Bnpy: 2-benzylpyridine; Inp: isonipecotic moiety; GlcN: amino-glucose scaffold; Au3-Au6) and the corresponding model nonglycosylated counterparts [Au(III)(2-Bnpy)(SSC-Inp-R)](PF6) (R: OEt (Au1), NH2 (Au2)) were generated and characterized by several anal. techniques (elemental anal., FTIR, 1H-/13C-NMR, ESI-MS, UV-visible, x-ray crystallog.). Their stability under physiol.-relevant conditions (PBS solution) and n-octanol/PBS distribution coefficient (D7.4) also were evaluated. Au(III) glycoconjugates showed an antiproliferative effect against ovarian carcinoma A2780 cells, with GI50 values in the low micromolar range. Remarkably, their cell growth inhibitory effect increases upon the addition of a glucose transporter 1 (GLUT1) inhibitor, thus ruling out the involvement of GLUT1 in their transport inside the cell. Addnl. mechanistic studies were carried out in A2780 cells, supporting the hypothesis of a facilitated diffusion mechanism (possibly mediated by glucose transporters other than GLUT1), and revealing their capability to act as topoisomerase I and II inhibitors and to disrupt mitochondrial membrane integrity, giving ROS, thus resulting in the promotion of oxidative stress and, eventually, cell death. In addition to this study using Piperidine-4-carboxamide, there are many other studies that have used Piperidine-4-carboxamide(cas: 39546-32-2Safety of Piperidine-4-carboxamide) was used in this study.

Piperidine-4-carboxamide(cas: 39546-32-2) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Safety of Piperidine-4-carboxamide

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Category: piperidinesOn May 5, 2022 ,《Monodispersed CuO nanoparticles supported on mineral substrates for groundwater remediation via a nonradical pathway》 appeared in Journal of Hazardous Materials. The author of the article were Wang, Gen; Zhang, Yue; Ge, Lei; Liu, Zhuoyue; Zhu, Xiurong; Yang, Shengjiong; Jin, Pengkang; Zeng, Xiangkang; Zhang, Xiwang. The article conveys some information:

Nonradical oxidation based on singlet oxygen (1O2) has attracted great interest in groundwater remediation due to the selective oxidation property and good resistance to background constituents. Herein, recoverable CuO nanoparticles (NPs) supported on mineral substrates (SiO2) were prepared by calcination of surface-coated metal-plant phenolic networks and explored for peroxymonosulfate (PMS) activation to generate 1O2 for degrading organic pollutants in groundwater. CuO NPs with a close particle size (40 nm) were spatially monodispersed on SiO2 substrates, allowing highly exposure of active sites and consequently leading to outstanding catalytic performance. Efficient removal of various organic pollutants was obtained by the supported CuO NPs/PMS system under wide operation conditions, e.g., working pH, background anions and natural organic matters. Chem. scavenging experiments, ESR tests, furfuryl alc. decay and solvent dependency experiments confirmed the formation of 1O2 and its dominant role in pollutants removal. In situ characterization with ATR-FTIR and Raman spectroscopy and computational calculation revealed that a redox cycle of surface Cu(II)-Cu(III)-Cu(II) was responsible for the generation of 1O2. The feasibility of the supported CuO NPs/PMS for actual groundwater remediation was evaluated via a flow-through test in a fixed-bed column, which manifested long-term durability, high mineralization ratio and low metal ion leaching. The experimental part of the paper was very detailed, including the reaction process of Triacetonamine(cas: 826-36-8Category: piperidines)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

SDS of cas: 826-36-8On May 5, 2022 ,《Modulated construction of Fe-based MOF via formic acid modulator for enhanced degradation of sulfamethoxazole:Design, degradation pathways, and mechanism》 appeared in Journal of Hazardous Materials. The author of the article were Sun, Jian; Wan, Jinquan; Wang, Yan; Yan, Zhicheng; Ma, Yongwen; Ding, Su; Tang, Min; Xie, Yongchang. The article conveys some information:

Metal-organic frameworks (MOFs) have attracted more attention because of their excellent environmental catalytic capabilities. Modulation approach as an advanced assistant strategy is vital essential to enhancing the performance of MOFs. In this study, the modulated method was used to successfully synthesize a group of Fe-based MOFs, with formic acid as the modulator on the synthesis mixture The most modulated sample Fe-MOFs-2 exhibit high sp. surface areas and higher catalytic activity, which could effectively degrade SMX via PS activation, with almost 95% removal efficiency within 120 min. The results revealed that the % RSE of modulated Fe-MOFs-2 increased from 2.31 to 3.27 when compared with the origin Fe-MOFs. This may be due to the addition of formic acid induces the formation of more coordinatively unsaturated metal sites in the catalyst, resulting in structural defects. In addition, the quenching experiment and EPR anal. verified SO-4·and·OH as the major active free radicals in the degradation process. Modulated Fe-MOFs-2 demonstrated good reusability and stability under fifth cycles. Finally, four possible degradation pathways and catalytic mechanism of Fe-MOFs-2 was tentatively proposed. Our work provides insights into the rational design of modulated Fe-MOFs as promising heterogeneous catalysts for advanced wastewater treatment. The experimental part of the paper was very detailed, including the reaction process of Triacetonamine(cas: 826-36-8SDS of cas: 826-36-8)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.SDS of cas: 826-36-8

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In 2019,Organic Chemistry Frontiers included an article by Xu, Yuliang; Xu, Ze-Jun; Liu, Zhao-Peng; Lou, Hongxiang. Formula: C10H20N2O2. The article was titled 《Visible-light-mediated de-aminative alkylation of N-arylamines with alkyl Katritzky salts》. The information in the text is summarized as follows:

A visible-light-mediated de-aminative alkylation of N-arylamines was developed, providing direct access to α-amino C-H functionalization of N-arylamines from readily available Katritzky salts under mild conditions to get tetrahydroisoquinolines, e.g., I, and alkyl-N-aryl-aminoesters, e.g., II. In some cases, this operationally simple protocol could be performed in the absence of a photocatalyst. A wide range of substrates and functional groups were tolerated. The utility of this approach was highlighted by its application to the late-state modification of drug mols., natural products and peptides. The experimental part of the paper was very detailed, including the reaction process of tert-Butyl 4-aminopiperidine-1-carboxylate(cas: 87120-72-7Formula: C10H20N2O2)

tert-Butyl 4-aminopiperidine-1-carboxylate(cas: 87120-72-7) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Formula: C10H20N2O2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

The author of 《Robust poly(aryl piperidinium)/N-spirocyclic poly(2,6-dimethyl-1,4-phenyl) for hydroxide-exchange membranes》 were Chen, Nanjun; Lu, Chuanrui; Li, Yunxi; Long, Chuan; Zhu, Hong. And the article was published in Journal of Membrane Science in 2019. Recommanded Product: 1-Methyl-4-piperidone The author mentioned the following in the article:

Herein, for realizing the high efficiency and long lifetime of hydroxide exchange membranes (HEMs) for alk. membrane fuel cell (AMFC) applications, a series of robust poly(biphenyl piperidinium) (PBP)/6-azaspiro[5.5] undecane (ASU)-functionalized polyphenyl ether (ASU-PPO) membranes were prepared by a crosslinked strategy. Crosslinked PBP-ASU-PPO membrane combines the advantage of PBP and ASU-PPO membranes as well as addresses the problem of high water uptake of PBP and the insufficient film-forming property of ASU-PPO. As expected, these crosslinked PBP-ASU-PPO membranes exhibit commendably comprehensive performances, such as good ion conductivity, durability, and mech. properties. The crosslinked PBP-ASU-PPO membrane reaches a maximum OH- conductivity of 128 mS/cm at 80 °C, accompanying with a 15.7% membrane swelling. Besides, only 13.6% degradation in Cl- conductivity was observed in PBP-ASU-PPO after alk. treatment in 1 M NaOH at 80 °C for 2000 h. Besides, the selected PBP-ASU-PPO membrane achieves a maximum power d. of 324 mW/cm2 at c.d. of 750 mA/cm2. The results came from multiple reactions, including the reaction of 1-Methyl-4-piperidone(cas: 1445-73-4Recommanded Product: 1-Methyl-4-piperidone)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.Recommanded Product: 1-Methyl-4-piperidone

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

The author of 《An improved process for the preparation of pimavanserin tartrate》 were Wu, Caijiao; Zhou, Qifan; Song, Dake; Li, Hui; Bao, Changshun; Liu, Xuelong; Bao, Xuefei; Chen, Guoliang. And the article was published in Journal of Chemical Research in 2019. COA of Formula: C6H11NO The author mentioned the following in the article:

A practical synthetic route to pimavanserin tartrate, I in which the target compound was obtained with 99.84% purity and in 46% total yield via a 5-step synthesis starting from 4-hydroxybenzaldehyde and (4-fluorophenyl)methanamine, was reported. The main advantages of the route included inexpensive starting materials, mild reaction conditions and an acceptable overall yield.1-Methyl-4-piperidone(cas: 1445-73-4COA of Formula: C6H11NO) was used in this study.

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.COA of Formula: C6H11NO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Chen, Sheng; Peng, Hanqing; Hu, Meixue; Wang, Gongwei; Xiao, Li; Lu, Juntao; Zhuang, Lin published their research in ACS Applied Energy Materials in 2021. The article was titled 《Ultrathin Self-Cross-Linked Alkaline Polymer Electrolyte Membrane for APEFC Applications》.Reference of 1-Methyl-4-piperidone The article contains the following contents:

Ultrathin alk. polymer electrolyte (APE) membranes have become a hot research topic for high-performance alk. polymer electrolyte fuel cells (APEFCs). To our knowledge, freestanding ultrathin membranes with thicknesses of or below 10 μm have never been reported for successful applications in APEFCs. The obstacle comes from the poor mech. strength of the ultrathin membrane during the fuel cell assembly. Herein we report an ultrathin 10 μm membrane made of cross-linked quaternary ammonia poly(N-methylpiperidine-co-p-terphenyl), denoted cQAPPT. This ultrathin cQAPPT membrane is robust enough for fuel cell assembly and demonstrates a high H2/O2 peak power d. of 1.85 W/cm2 at 80 °C. In the part of experimental materials, we found many familiar compounds, such as 1-Methyl-4-piperidone(cas: 1445-73-4Reference of 1-Methyl-4-piperidone)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.Reference of 1-Methyl-4-piperidone

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Chen, Nanjun; Hu, Chuan; Wang, Ho Hyun; Park, Jong Hyeong; Kim, Hae Min; Lee, Young Moo published their research in Journal of Membrane Science in 2021. The article was titled 《Chemically & physically stable crosslinked poly(aryl-co-aryl piperidinium)s for anion exchange membrane fuel cells》.Reference of 1-Methyl-4-piperidone The article contains the following contents:

Poly(aryl-co-aryl piperidinium) (c-PAP) copolymers have recently demonstrated great successes in anion exchange membranes (AEMs) and ionomers for AEM fuel cells (AEMFCs). Here, we present a series of in-situ styrene-crosslinked c-PAP (x-PAP-PS) membranes to further enhance the mech. strength, dimensional stability, and water retention capacity of c-PAP AEMs. Specifically, x-PAP-PS AEMs simultaneously possess high ion conductivity (>150 mS cm-1), tensile strength (>80 MPa), and chem. and mech. durability (∼90% ion conductivity and mech. strength maintaining in 1 M NaOH at 80°C for 2160 h). Addnl., x-PAP-PS-based AEMFCs reached peak power densities (PPDs) of 2.23 W cm-2 in H2-O2 and 1.32 W cm-2 in H2-air at 80°C. Importantly, compared to pristine c-PAP AEMs, x-PAP-PS AEMs display higher water retention capacity at low relative humidity (RH), and the corresponding AEMFCs reach PPDs >1 W cm-2 with Pt/C at 30%/30% RH at 90°C. Moreover, the x-PAP-PS-based AEMFCs can be operated stably under a 0.4 A cm-2 c.d. at 60°C for ∼120 h. The results came from multiple reactions, including the reaction of 1-Methyl-4-piperidone(cas: 1445-73-4Reference of 1-Methyl-4-piperidone)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Reference of 1-Methyl-4-piperidone

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Zhou, Xixing; Wu, Lexuan; Zhang, Guangxu; Li, Ruyu; Hu, Xu; Chang, Xuanwei; Shen, Yinghua; Liu, Lei; Li, Nanwen published their research in Journal of Membrane Science in 2021. The article was titled 《Rational design of comb-shaped poly(arylene indole piperidinium) to enhance hydroxide ion transport for H2/O2 fuel cell》.Category: piperidines The article contains the following contents:

To produce anion exchange membranes (AEMs) possessing high conductivity and chem. stability, we propose a ternary copolymerization strategy to prepare comb-shaped poly(arylene indole piperidinium) copolymers with different lengths of side chain by the design of alkyl-functionalized isatin comonomers in the acid-catalyzed Friedel-Crafts polycondensations of N-methyl-4-piperidone and p-terphenyl. These polymers have a characteristic feature of hydrophobic side chain sep. attached onto aryl-ether free backbones to induce microphase separated morphol. and stable piperidinium cation within the backbone to ensure the alk. stability. PITP-C10Q85 membrane with C10 side chain showed the highest hydroxide conductivity of 134.5 mS/cm at 80 °C due to the formed microphase separated morphol. Alk. stability testing in 1 M NaOH at 80 °C demonstrated that 80% of initial conductivity was retained for PITP-C10Q85 membrane after 1200 h of testing, owning to the chem. degradation of piperidinium cation in comb-shaped membranes via Hoffman elimination and nucleophilic substitution reaction. By assembling in alk. fuel cells, PITP-C10Q85 membrane delivered a peak power d. of 445 mW/cm2 at a c.d. of 870 mA/cm2 at 60 °C. Meanwhile, in-situ stability of PITP-C10Q85 membrane demonstrated a voltage decay rate of 3.67 mV/h over 75 h of operating at 300 mA/cm2, and post-cell anal. of the aged membrane revealed that predominant nucleophilic substitution reaction was found for the degradation of PITP-C10Q85 membrane, being different from the degradation mechanisms in the ex-situ stability tests. The above results manifested that regulating the alkyl side chains on the backbone directly is a promising strategy to achieve high performance AEMs with favorable morphol., high conductivity and alk. fuel cell performance. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-piperidone(cas: 1445-73-4Category: piperidines)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Pediconi, Natalia; Ghirga, Francesca; Del Plato, Cristina; Peruzzi, Giovanna; Athanassopoulos, Constantinos M.; Mori, Mattia; Crestoni, Maria Elisa; Corinti, Davide; Ugozzoli, Franco; Massera, Chiara; Arcovito, Alessandro; Botta, Bruno; Boffi, Alberto; Quaglio, Deborah; Baiocco, Paola published an article in 2021. The article was titled 《Design and Synthesis of Piperazine-Based Compounds Conjugated to Humanized Ferritin as Delivery System of siRNA in Cancer Cells》, and you may find the article in Bioconjugate Chemistry.HPLC of Formula: 1445-73-4 The information in the text is summarized as follows:

Gene expression regulation by small interfering RNA (siRNA) holds promise in treating a wide range of diseases through selective gene silencing. However, successful clin. application of nucleic acid-based therapy requires novel delivery options. Herein, to achieve efficient delivery of neg. charged siRNA duplexes, the internal cavity of “”humanized”” chimeric Archaeal ferritin (HumAfFt) was specifically decorated with novel cationic piperazine-based compounds (PAs). By coupling these rigid-rod-like amines with thiol-reactive reagents, chemoselective conjugation was efficiently afforded on topol. selected cysteine residues properly located inside HumAfFt. The capability of PAs-HumAfFt to host and deliver siRNA mols. through human transferrin receptor (TfR1), overexpressed in many cancer cells, was explored. These systems allowed siRNA delivery into HeLa, HepG2, and MCF-7 cancer cells with improved silencing effect on glyceraldehyde-3-phosphate dehydrogenase (GAPDH) gene expression with respect to traditional transfection methodologies and provided a promising TfR1-targeting system for multifunctional siRNA delivery to therapeutic applications. In the experiment, the researchers used 1-Methyl-4-piperidone(cas: 1445-73-4HPLC of Formula: 1445-73-4)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.HPLC of Formula: 1445-73-4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem